Preparation "Vasar N 160": instructions for use, description, composition and reviews

Many people suffer from hypertension. Moreover, the increase in pressure may not be accompanied by any signs, but revealed in a random way, in the process of its measurement. Although in some cases this condition is still accompanied by a headache, flickering flies before the eyes and dizziness.

Lowering of high blood pressure should be mandatory. As a rule, special medicines are used for this. One of them is the drug "Vasar N"( 160).Instructions for use, reviews, composition and cost of this medication are discussed below.

Form, Composition of the Drug

In what form do you produce the medicine "Vazar N"( 160)?Instruction for use informs that this product is manufactured in the form of tablets with a film coating. Their main substances are valsartan, as well as hydrochlorothiazide. In addition, the composition of this drug includes additional ingredients such as lactose monohydrate, croscarmellose sodium, povidone, silicon anhydrous colloid, microcrystalline cellulose, magnesium stearate and talc.

Pharmacological action of the drug

What is the drug "Vazar N"( 160)?Instructions for use, reviews report that this is a combination drug that is designed to treat hypertension.

The main substance of the drug in question is an angiotensin 2 blocker( its receptors).He actively participates in the regulation of the function of the heart and blood vessels. It should also be noted that this drug does not block and does not promote the binding of ion channels and other hormonal receptors.

As for hydrochlorothiazide, it is a diuretic( that is, a thiazide diuretic).It is an antihypertensive agent that reduces the reabsorption( renal) of electrolytes, and also increases the excretion of sodium, chlorine, bicarbonate, potassium, water and magnesium. In addition, this tool increases the content of renin in the blood.

The combination of the two substances in question is more conducive to a pronounced hypotensive effect than their use alone.

Pharmacokinetic parameters

Where is the absorption of the drug "Vazar N"( 160)?Instructions for use asserts that valsartan is instantly absorbed from the digestive tract. And the degree of its absorption is variable.

Biological availability( absolute) of this component is 23%, and the connection with plasma proteins is 95-97%.The excretion of valsartan occurs through the intestine and kidneys.

Hydrochlorothiazide is also very rapidly absorbed from the intestine. Its peak concentration is achieved after 120 minutes, and the bioavailability is 65-85%.

The elimination half-life of the substance in question varies between 6-15 hours( by means of the kidneys).

Indications for taking oral tablets

When can a drug such as Vasar N( 160 / 12.5) be prescribed? Instruction for use reports that this medication is used to treat conditions that are associated with hypertension.

Prohibitions for taking medication

When should I not take the drug "Vasar N"( 160)?Instructions for use indicate such contraindications as:

• anuria;
• Hypersensitivity to any of the drug substances;
• refractory hypokalemia;
• pathology of liver function of a serious nature;
• cirrhosis and cholestasis;
• hyponatremia;
• pathology of kidney function is severe;
• hypercalcemia;
• hyperuricemia symptomatic;
• hypersensitivity to other sulfonamides.

Medicinal product "Vasar N"( 160): instruction for use

Analogs of the medicine will be listed below.

Take the "Vasar N" tablets orally, with a small amount of liquid, regardless of the meal.

According to the instructions, the daily dosage( initial) of this remedy is 80 mg / 12.5 mg. If the indicated dose was ineffective( for 3-4 weeks), the course of treatment is continued at a daily dose of 160 mg / 12.5 mg. Usually such dosage of a preparation is shown to people at insufficient depression of a BP at reception initial.

If required, the amount of the drug may subsequently be increased to 320 mg / 12.5 mg per day.

Stable effect of taking the drug in question is achieved after 2-4 weeks.

Side effects( after taking the tablets)

What are the undesirable reactions caused by the drug "Vazar N"( 160)?Instructions for use asserts that taking valsartan can provoke:

• orthostatic hypotension, neuralgia, back pain;
• diseases( infectious) of the respiratory tract, including sinusitis and pharyngitis;
• diarrhea, epistaxis, hypotension;
• conjunctivitis, weakness, arthritis, cough;
• insomnia, syncope, heart failure;
• depression, pain in the abdomen, asthenia, bleeding;
• myalgia, rashes, hyperkalemia, itching;
• arthralgia, headaches, gastroenteritis, thrombocytopenia;
• vasculitis, angioedema, rhinitis, impaired renal function.

As for hydrochlorothiazide, this substance sometimes causes:

• jaundice, hyperuricemia, arrhythmias;
• hypokalemia, pancreatitis, orthostatic hypotension;
• pulmonary edema, increase in the number of lipids in the blood, pneumonitis.

Cases of an overdose of

tablets Taking more than the maximum doses can contribute to the development of severe arterial hypotension. Often such a condition causes a shock or heart failure.

When overdosed with hydrochlorothiazide, the patient may develop a feeling of nausea, hypovolemia, drowsiness, electrolytic disorders associated with spasms( muscle) and arrhythmia.

Drug interaction

Simultaneous administration of cimetidine, glibenclamide, indomethacin, furosemide, atenolol, digoxin, hydrochlorothiazide, warfarin and amlodipine does not result in a significant interaction with Vasar N".

Prolonged treatment with NSAIDs can reduce the diuretic and hypotensive effects of the drug in question, as well as lead to impaired renal function.

When combined with holinoblokatorami increases the bioavailability of hydrochlorothiazide.

Special recommendations

Now you know what is prescribed from such a drug as "Vasar N"( 160).Instructions for use, the price of this medication is presented in this article.

With special caution this drug is recommended for people with cirrhosis of the liver, myocardial infarction, CHF, bilateral stenosis of the renal artery, and also in combination with potassium, potassium-sparing diuretics and ACE inhibitors.

For patients with liver damage( non-cholestatic), the dosage of the drug in question should not exceed 80 mg( valsartan).

Reviews, analogues, price

The cost of the medicine in question is about 200-600 rubles( depends on the dosage).Analogues of this drug include: Teveten Plus, Micardis Plus, Lorista N, Cardosal Plus, Lozap Plus, Olimestra N.

The drug "Vasar N" has established itself as a very effective drug intended for the treatment of hypertension. According to consumers' reviews, this medication rarely causes side effects, and is also convenient to use and easily accessible.