"Diocor 160": instructions for use, reviews, analogues."Diocor solo 160": user manual, reviews
A huge number of people occasionally suffer from increased blood pressure. However, such a pathological condition not only brings tangible discomfort to the patient, but also threatens his life. Therefore, in the modern pharmaceutical market, there are many drugs that contribute to lowering blood pressure. 
The most popular among those people who regularly suffer from hypertension, is a medication such as "Dyokor 160".Instructions for use, analogs of this medication, as well as reviews about it, features and properties will be presented below.
Composition, description, packaging and form
The medicine "Diocor 160", the instruction of which is contained in a cardboard box, is made in the form of tablets. They are film-coated and contain active ingredients such as valsartan and hydrochlorothiazide. Also included in the composition are microcrystalline cellulose, sodium lauryl sulfate, potato starch, talc, corn starch, croscarmellose sodium, magnesium stearate, colloidal anhydrous silicon dioxide and opadry II Orange.
We can not say that there is a drug such as "Dyokor Solo 160" on sale. From the previous one, it differs in that its active ingredient is only valsartan.
Principle of action of the drug
What is the preparation "Diorcor 160"?Instruction for use reports that this antihypertensive agent, which includes a thiazide diuretic and an antagonist of angiotensin II receptors.
This drug has a wide range of physiological effects that take both mediated and direct participation in the regulation of blood pressure. Angiotensin II is a strong vasoconstrictor caused by direct vasopressor action. It also delays sodium and stimulates the secretion of aldosterone.
Valsartan is a specific and active antagonist of angiotensin II receptors. It is designed for oral administration and selectively acts on the receptors of the AT1 subtype, which is responsible for the effects of angiotensin II.Partial agonistic activity in relation to receptors of the AT1 subtype does not manifest this element.
Also, valsartan does not inhibit ACE which converts angiotensin I to angiotensin II, destroying bradykinin. There are no side effects due to bradykinin.
In people with hypertension this medication causes a decrease in blood pressure. However, it does not affect the heart rate. 
In many patients after receiving a single dose of the drug in question, the onset of antihypertensive activity is observed within 2 hours, and the decrease in blood pressure after 6 hours.
The antihypertensive effect of the drug persists for more than a day. With the regular administration of tablets, the maximum therapeutic effect is achieved within four weeks and is maintained during all long-term therapy.
Pharmacokinetics
What are the kinetic properties of the "Diocor 160" medication? Instructions for use( tablets should appoint only a doctor) says that after taking the drug inside the absorption of hydrochlorothiazide and valsartan is very fast. The average indicator of absolute bioavailability of this drug is 23%.
The kinetics of valsartan is linear. Repeated use of the drug does not change. With a single intake of tablets, their cumulation is negligible.
Valsartan binds to plasma proteins by 94-98%.Its excretion is carried out together with feces and urine. When taking valsartan with food, AUC is reduced by 48%.
After taking the pills inside, the absorption of hydrochlorothiazide occurs fairly quickly( about 2 hours).At the same time, its bioavailability is 60-80%.It is excreted together with urine.
When the combination of valsartan and hydrochlorothiazide, the systemic bioavailability of the latter is reduced by about 30%.
Indications for the use of tablets
Under what conditions can a patient be prescribed a medicine "Diocor 160"?Instructions for use, reviews of doctors report that this tool is very well manifested in hypertension, as well as with insufficient effectiveness of monotherapy of this disease. 
Contraindications to the ingestion of tablets
Do you know when the DioCor 160 tablets are not prescribed? The instruction says that such a medicine is contraindicated in case of individual intolerance to its ingredients.
In addition, it is prohibited for use in patients with cholestasis, expressed by impaired liver function and biliary cirrhosis. Also, it is not prescribed to people suffering from any form of severe and moderate renal dysfunction, a symptom of anuria, a decreased level of sodium or potassium in the blood, hypercalcemia and hyperuricemia.
Diocor 160 tablets: instructions for use
As a rule, to eliminate high blood pressure at home, patients are recommended to use one "Diocor 80" tablet once a day. As for the drug "Dyokor 160", it is prescribed only in the hospital. Thus the patient should be under constant supervision of the doctor.
As practice shows, a noticeable effect with severe hypertension is observed 2-3 weeks after the initiation of therapy.
For people with mild or significant hepatic or renal insufficiency, it is necessary to correct the indicated dosage( individually).
The duration of therapy with this medication should be determined only by the treating doctor.
Side effects of
What side effects should a patient know before using a "Diocor Solo 160" medication? Instructions for use say that the drug in question rarely causes undesirable effects, which are unstable and weakly expressed.
Approximately 1% of patients had weak headaches, back pain, fatigue, cough, dizziness, and nasopharyngitis when taking this medication. 
Less than 1% complained of abdominal pain, anxiety, discomfort in the neck and chest, asthenia, joint pain, serous bronchitis, drowsiness, laryngitis, dyspnea, dyspeptic disorders, decreased erection, decreased salivation, hypotension, gastroenteritis, paresthesia, increased sweating, decreased sensitivity, muscle cramps, sleep disorders, peripheral edema, nausea, otitis, nasal congestion and a slight increase in body temperature. Occasionally, patients had a weakened vision, unstable tachycardia, and tinnitus. At the same time, it should be noted that the direct relationship between the appearance of these reactions and the drug has not been established.
What other side effects can the "Diocor Solo 160" medication cause? Instructions for use indicate that when using this tool, there were isolated cases of rash, itching and other manifestations of an allergic nature, including vasculitis, as well as serum sickness. In addition, patients sometimes developed myalgia and nephral dysfunction.
The most rare form of side effects when taking DioCor 160 is a mild non-cardiogenic edema that is associated with individual intolerance to hydrochlorothiazide.
Studies have shown that in some patients treated with this drug, the potassium content in the blood decreased, the indices of creatinine and urea increased, and moderate neutropenia was detected.
Symptoms of an overdose of
What are the symptoms when taking large doses of the drug "Diocor Solo 160"?The instruction says that such cases are not known to date.
The main sign of increased medication intake can be pronounced hypotension. If the drug was taken relatively recently, then the victim is required to artificially induce vomiting. Also, the fight against hypotension can be carried out by intravenous injection of saline.
It should be remembered that it is impossible to withdraw the medication in question from the body by hemodialysis. This is due to the fact that valsartin, which is part of its composition, reacts with plasma proteins. However, it should be noted that hydrochlorothiazide is eliminated in this way quite successfully. 
Drug interaction with other drugs
Is it possible to combine "Diorcor 160" with other drugs? The instruction says that the combination of this drug with other drugs of the antihypertensive group can contribute to the enhanced effect of lowering blood pressure.
Simultaneous use of the drug with potassium-containing additives, mild diuretics, salt substitutes and substances that increase the potassium content in the body requires regular testing of serum potassium concentration.
With the simultaneous reception of "Diocor" with ACE inhibitors, a reversible increase in the concentration of lithium in the blood was detected.
With what medications can you safely use the medicine "Diocor 160"?The manual reports that with the monotherapy of hypertension, this agent did not notice any interaction with Glibenclamide, Amlodipine, Warfarin, Cimetidine, Digoxin, Furosemide, Indomethacin and Atenolol.
Because of the diuretic of the thiazide group, the following interactions are likely to occur:
- a decrease in the diuretic effect of the drug when used together with NSAIDs( eg, salicylates or indomethacin);
- potentiation of muscle relaxants.
What other drug interactions should you know before taking Dioxor 160?The instruction, the reviews indicate that with the simultaneous use of this remedy with potassium-sparing diuretics, salicylates, ACTH, carbenoxflunon and amphotericin, a sharp decrease in potassium concentration in the blood is possible.
When using injectable and oral hypoglycemic drugs, it is necessary to carry out individual adjustment of their dosages. 
It is highly not recommended to use this medication together with diuretics of the thiazide group, as this may increase the side effects of the above drugs and cause hypersensitivity reactions.
With the simultaneous use of hydrochlorothiazide with methyldopa, hemolytic anemia can develop.
With the combination of "Diocor 160" and colestyramine, its bioavailability and absorption decreases.
When taking the drug with vitamin D, patients may have a higher concentration of calcium in the blood.
Do not take Dicor with cyclosporine, as this can cause gouty symptoms and a state of hyperuricemia.
Special recommendations for the reception of tablets
What should I know about before using Diocor Solo 160?Instructions for use, reviews say that during treatment with this medication the patient should regularly determine serum levels of electrolytes in the blood.
In case of hypotension, the injured person must be transferred to a horizontal position. If required, an intravenous infusion of physiological saline is performed. After stabilizing the pressure, therapy can be continued.
In people with bilateral or unilateral stenosis of the renal artery, taking valsartan can cause an increase in the level of creatinine or urea in the blood.
When medication is prescribed for patients with impaired renal function, dose adjustment is not required, but periodic monitoring of creatinine and uric acid, as well as potassium content in the blood, is necessary.
There is evidence that thiazide diuretics can exacerbate systemic lupus erythematosus. They also change the patient's tolerance to glucose, increase the concentration of cholesterol, uric acid and TG in the blood. In connection with this, a diabetic patient may need to adjust the dose of oral hypoglycemic agents or insulin.
In patients with moderate and minor liver disorders without cholestasis, dose adjustment is not required. But with such conditions, the drug should be taken with extreme caution.
There are reports of cases of photosensitization with thiazide diuretics. If the photosensitivity reaction occurs during the therapy, the treatment should be stopped. 
If it is necessary to reintroduce a diuretic, vulnerable areas should be protected from artificial ultraviolet irradiation or sun.
Analogues of the preparation
How can we replace the agent we are considering? According to specialists, similar drugs have such drugs as Avia-Sea, Dentokind, Inzen, Zinnabsin, Softovak, Medotsef, Vinblastin-Teva.
Reviews about
Now you know how to use the medicine "Dyokor 160".Instructions for use of this medication have been described in detail above.
This tool is very popular among patients and doctors. Experts say that it effectively manifests itself in the presence of severe arterial hyperplasia. Consumers fully agree with this. According to their reviews, taking one pill helps restore blood pressure, as well as alleviate their condition.
One can not but note the fact that this drug has a convenient form of release and dosage. However, take an increased dose of this medication only in a hospital, under the supervision of a doctor.