Tablets "Nimesan": instructions for use, composition, analogues and reviews

The drug "Nimesan" is popular in the market of medicines. It refers to non-steroidal anti-inflammatory drugs. The main active substance is nimesulide. This is confirmed by the Nimesan tablets instructions for use. They have an analgesic effect, help with inflammation, and also at elevated body temperature. nimesan tablets instructions for use

Dosage form and composition

The preparation is produced in the form of triangular tablets of light yellow color. What do they consist of? The Nimesan tablets include 100 mg of nimesulide, excipients: corn starch, lactose monohydrate, talc, crospovidone, propyl parahydroxybenzoate, magnesium stearate.

How to apply and in what dosages?

Is taken orally after a meal, fifty and one hundred mg twice a day. If there is chronic hepatic insufficiency, then in a daily dose of one hundred mg. It is better to use the minimum dose, and reduce the course of treatment. Children aged 12 years are prescribed a single dose at a rate of 1.5 mg / kg of body weight, in the maximum daily dose of the drug - five mg / kg per day. nimesan tablets user manual

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Pharmacological action

As indicated by the instruction on the use of Nimesan tablets, they contain a sulfonamide group. It is suggested that nimesulide is a selective inhibitor of cyclooxygenase( COX-2).The drug has anti-inflammatory, analgesic, as well as antipyretic effect. The mechanism of action of the drug "Nimesan" is associated with the oppression of prostaglandins. The synthesis of these prostaglandin substances is inhibited in the area of ​​very severe inflammation, but this is not manifested in the kidney and stomach mucosa, because the second type of cyclooxygenases is mainly inhibited.

In addition, it should be noted that the mechanism of anti-inflammatory action of this medication is due to the ability to inhibit the formation of free oxygen radicals. This does not affect phagocytosis and hemostasis in any way.
This confirms the instructions for use with Nimesan tablets. The price is of interest to many buyers. In drugstores the drug costs from 165 rubles. nimesan tablets user manual

Pharmacokinetics

When ingested, the drug is absorbed well and quickly from the digestive tract. The maximum concentration of the active substance in the blood is observed already two hours after the first intake of the drug. In 99% it binds to proteins, and after a single dose of 100 mg the substance is found in the tissues of the sexual organs of women. Metabolised by the liver. The half-life of the drug from the blood is three hours. Active active substance is excreted together with urine within 24 hours.

Indications for use

Tablets "Nimesan"( instructions for use confirm this) is prescribed in the following cases:

  • rheumatic diseases of various kinds that occur outside the joints;
  • osteoarthritis;
  • acute inflammatory processes in the upper respiratory tract, accompanied by fever;
  • severe pain during menstruation;
  • inflammatory processes and pains that have arisen after surgical intervention.

review about tablets shreya nimesan

Contraindications to the use of the drug

Contraindications to the use of this medication include:

  • the formation of ulcers in the stomach and duodenum, in an aggravated form;
  • any degree of functional impairment of the liver;
  • Acute bleeding from the digestive tract;
  • impaired renal function;
  • lactation period;
  • pregnancy;
  • is hypersensitivity to the active active substance of the drug - nimesulide and other NSAIDs.

All this is confirmed to the tablets "Nimesan" instructions for use and feedback. Dosage and route of administration:

  • The maximum allowable daily dose of the drug for adults is 400 mg( that is, four 100 mg tablets), for children 5 mg per day for 1 kg of body weight. Adults are prescribed to drink tablets of 100-200 mg, washed down with a large amount of water, twice a day after meals. Children are prescribed 1.5 mg per 1 kg of weight, also with water, two or three times a day after meals.

nimesan analgesic reviews of doctors

Side effects when taking

As a rule, Nimesan tablets( instructions for use are available in each pack) are well tolerated by the body, but sometimes they cause some side effects. These include:

  • stomach pain, nausea, heartburn, in rare cases, there is a violation of the stool;
  • dizziness, headaches, drowsiness;
  • erythema, skin rash, hives;
  • is very rare - fluid retention in the body, oliguria, systemic or local edema.

Reviews of the tablets Shreya "Nimesan" will be discussed below. Patient interaction: should be particularly careful during the simultaneous use of the drug with phenytoin, digoxin, lithium preparations, other NSAIDs.

Special instructions

The Nimesan preparation should be taken with caution to patients with renal insufficiency, heart problems, visual impairment. During external application it is necessary to supervise a specialist for elderly patients who have renal, hepatic or heart failure. For children, special dosage forms should be used.

Due to the fact that use of the drug may cause drowsiness and dizziness, one should be especially cautious of patients engaged in hazardous activities, where high concentration of attention and rapid psychomotor reactions are required. This is confirmed by the pain-relieving "Nimesan" reviews of doctors. tablet nimesan composition

Use by pregnant women

The drug is strictly contraindicated for use during pregnancy and during breastfeeding.

Interaction of

Simultaneous application of "Nimesan" with drugs that reduce blood clotting, enhances this effect. Nimesulide may reduce the action of furosemide. Reduces the therapeutic effect of antihypertensive medications. The possibility of side effects with the use of methotrexate is increasing. Lithium and nimesulide simultaneously increase the level of the first in blood plasma. Nimesulide enhances the action of cyclosporin on the kidneys. Glucocorticosteroids, serotonin reuptake inhibitors increase the risk of bleeding from the gastrointestinal tract. In general, any drug must be combined with another very carefully, it should only be done under the supervision of a doctor.

Analogues of Nimesan

The following medicines are considered analogues: Nimesulide, Nimulid, Naize, Nemuxlex, Nimika, Nimesil, Aponil, Nimesulid-TEVA.Analogues can cost cheaper or more expensive, it all depends on the manufacturer.

Reviews of

Basically, consumers note that the drug "Nimesan" quickly relieves pain, lasts for five hours, has a convenient form of release in the form of tablets and a pleasant price. But it also has a large number of contraindications and side reactions, which, fortunately, are rarely observed. The doctors' comments about him are only positive. The product effectively reduces body temperature, relieves even severe pain.