Instruction for the application of Clopixol, a description of the drug, reviews
What is a drug such as Clopixol? Comments of consumers and features of this medication will be considered in the materials of this article. 
Forms of the preparation, its composition, description, packaging
The product under consideration has different forms of release. Imagine them right now.
1. "Klopiksol" - tablets of pale pink, rosy-brown and red-brown color( 2 mg, 10 mg and 25 mg respectively).They have a round and biconvex form, as well as a film shell.
The active ingredient of this agent is zuclopenthixol dihydrochloride. It also contains 85% glycerol, potato starch, copovidone, lactose monohydrate, microcrystalline cellulose, talc, magnesium stearate, hydrogenated castor oil.
The medicine in question is sold in plastic containers and carton boxes.
2. Oily solution for the / m administration of Clopixol. Reviews say that this product is sold in ampoules of colorless glass. The solution itself is yellowish in color and transparent. It is completely free of particles.
An active element of this medication is zuclopenthixola decanoate. It also contains triglycerides.
Pharmacological action of "Klopiksola"
This medication is a thioxanthene derivative, an antipsychotic. It has a specific inhibitory and antipsychotic effect. In addition, this agent has a sedative effect.
A single injection of the drug contributes to the rapid easing of all psychotic symptoms. Sedative properties of the drug appear after 2 hours, and its overall effect continues for 3 days.
Kinetic features of the preparation
According to experts, it is advisable to carry out injections with this solution by periods( once every 4 weeks).
After oral administration of the drug, its peak concentration is reached after 4 hours. The biological availability of zuclopentixol is approximately 44%.
After intramuscular injection, the basic substance of this drug undergoes enzymatic digestion. In this case, acetic acid and active zuclopentixol are formed. The latter component is excreted in small amounts with the mother's milk and penetrates the placental barrier.
When taken internally, the half-life of the drug is about 20 hours. It is excreted mainly together with feces and partly with urine.
Indications for use
When should the drug be prescribed to patients? What does the instruction for use say?"Klopiksol" is shown with:
- acute and chronic schizophrenia and other psychotic disorders, including those accompanied by delirium( paranoid), hallucinations and disturbances in thinking;
- state of agitation, hostility, anxiety( increased), aggressiveness;
- mental retardation, which is combined with agitation, agitation( psychomotor) and other disorders in behavior;
- manic phase of manic-depressive psychosis;
- senile dementia with disorientation, impaired behavior, paranoid ideas and confusion.
Prohibitions on the use of the drug
When should not you use this antipsychotic? What does the instruction for use say?"Clopixol" is contraindicated in:
- acute intoxication with barbiturates;
- alcohol intoxication of an acute nature;
- acute intoxication with analgesics( opioid).
It should also be noted that this antipsychotic agent is not used in comatose conditions.
Instructions for use
"Clopixol" in tablets are taken orally. The dosage of this drug is selected individually, depending on the patient's condition. At the very beginning of therapy, the medication is prescribed in low doses, and then rapidly increased until a clinical effect is achieved.
In severe and moderate psychotic disorders, the initial dosage of Clopixol is 20 mg per day. If required, it can be increased by 20 mg.
In case of an acute attack of schizophrenia and other psychotic disorders of an acute nature, mania and severe agitation, the dosage of the drug is 10-50 mg per day.
In psychotic states of a chronic nature, as well as in schizophrenia and other psychoses, the maintenance dosage of the drug in question is 20-40 mg per day.
When agitating in people with oligophrenia, the dose of the drug is 6-20 mg per day. If necessary, it can be increased to 25-40 mg per day.
In senile disorders with agitation and confusion, this medication is prescribed in a dose of 2-6 mg per day. If required, the indicated amount of the drug is increased to 10-20 mg per day.
How to use the oil solution
How should I inject the oil solution? What does this tell us about the instructions for use?"Clopixol" is prescribed in the form of a deep intravenous injection, which is carried out in the gluteal region.
The recommended amount of this injection should be 1-3 ml. If required, repeat injections are done at intervals of 3 days. Some patients receive additional injections after a day or two.
Adverse effects of
What are the negative reactions caused by Clopixol? Side effects this drug causes very often. These include the following:
- urinary retention, disruption of accommodation;
- extrapyramidal symptoms( at the initial stage of therapy), drowsiness;
- tachycardia, dizziness, orthostatic hypotension;
- tardive dyskinesia( with long-term treatment);
- constipation, dry mouth, transient changes in hepatic samples.
Overdose cases of
In case of an overdose by the agent under consideration, the following symptoms are possible: coma, drowsiness, seizures, extrapyramidal disorders, shock, arterial hypotension, hypo- or hyperthermia.
To eliminate such phenomena, the patient is washed with a stomach and given sorbents. Also, supportive and symptomatic therapy is performed.
Drug Interactions
The drug Klopixol( 10 mg) enhances the sedative effect of alcohol, barbiturates and other drugs that have a depressant effect on the central nervous system.
This medication should not be combined with guanethidine and drugs with a similar effect due to the possible blocking of their hypotensive effect.
Simultaneous reception of "Klopiksola" can reduce the effectiveness of adrenergic drugs, including "Levodopy."
When combined with Piperazine and Metoclopramide, the risk of extrapyramidal symptoms increases.
Special recommendations
The drug "Klopixol", the price of which is indicated below, is cautiously prescribed for people with heart disease, chronic hepatitis and convulsive syndrome.
For prolonged treatment, ongoing clinical monitoring should be performed to assess the patient's condition.
With the administration of neuroleptics, it is possible to develop NSA with a fatal outcome. The main signs of this condition are muscle rigidity, impaired consciousness, dysfunction of the vegetative nervous system, hyperthermia.
The cost of the drug and reviews about it
The price of the medicine in question depends on the form of its release.2 mg tablets in the amount of 50 pieces cost about 250 rubles, 25 mg( 100 pieces) - about 1600 rubles, and 10 mg tablets( 50 pieces) - about 480 rubles.
As for the oil solution, its price reaches 2300 rubles.
Most often, consumer reviews about the drug Klopiksol are left by those patients who used this medication in the form of an injection solution. Such patients claim that the course of application of this remedy is very convenient. This is due to the fact that injections should be done extremely rarely( in contrast to taking tablets).
According to consumers' reviews, the drug Klopiksol is a very effective and quick-acting antipsychotic. But, unfortunately, it quite often causes side effects.