Renin - what is it? Definition

Renin. What is it, knows not everyone. It is one of the most important components that take part in the functioning of the human body. Thanks to him, there is a regulation of blood pressure and blood circulation. Some people compare this component to a water tap, which reduces or increases the diameter of the flow. Let's try to understand in more detail what the renin is and for what functions it is responsible.

General Information

Renin( what is it, will be discussed in this article) is excreted in the kidneys. For this, in fact, he received his definition, since from Latin his name is translated as a kidney component. For its synthesis is responsible okollubochkovy apparatus, which is a special cells located in the small arteries of the nephron. It produces protein, which during the chemical and biological processes occurring in the human body, is converted into renin. Such a component regulates the flow of blood to the nephrons and the volume of fluid entering this organ.

What influences the production of renin?

Renin( what it is, we already have an idea) is developed in the following cases:

• in case of a stressful situation;
• decrease in circulating blood levels;
• decrease in the volume of blood entering the renal ducts;
• low content of potassium or sodium in the body;
• for hypotension.

Renin promotes the cleavage of proteins produced by the liver, an oligopeptide hormone of the first degree, which is then split to the second level, resulting in a contraction of the muscular layer of the blood vessels. These changes provoke an increase in blood pressure and increase blood flow to the adrenal glands, stimulating them to work more effectively.

Thus, the renin-aldosterone system works in our body. However, that's not all. Some other hormones are responsible for regulation of the circulatory system, which will be discussed later.

Renin-angiotensin

What is this substance? Renin-angiotensin is another important hormone that exerts a strong influence on the functioning of the circulatory system and the regulation of blood pressure. When does its synthesis occur? It begins to be produced by the body when the blood pressure rises, and as a result it gradually becomes normal.

This hormone is synthesized only in the adrenal cortex. Therefore, too low or high content in the body, as a rule, indicates the presence of any disease or disruption of the kidneys, as well as that the person has abnormal blood pressure.

High renin content in the body

If the renin-angiotensin aldosterone system is present in the body in too large a quantity, which is significantly higher than the norm, this can lead to serious complications and pathologies. As a result, the normal operation of the internal organs can be disturbed. The greatest problems are observed in the work of the heart, kidneys and circulatory system. As a rule, people on an ongoing basis develop high blood pressure, leading to serious complications in the late stages.

All the insidiousness of this dangerous disease lies in the fact that in the early stages of development it is impossible to distinguish it from hypertension.

It is accompanied by the same symptoms:

• increased heart rate;
• tinnitus;
• migraine;
• dizziness.

With hypertension, a huge number of people today, especially those living in large cities and abusing alcohol, are facing. Therefore, the above symptoms are not uncommon. At occurrence even the slightest suspicions on chronic raised arterial pressure it is necessary to pass at once inspection, as this disease can not only cause irreparable harm to health, but also lead to a lethal outcome.

Age changes and blood pressure

So, renin - what is it? This substance is responsible for regulating blood pressure. If his level is too high or low, a person may have health problems. But here it is important to understand that blood pressure can be increased not only because of improper functioning of the adrenal cortex, but also to be caused by age-related changes.

As studies show, approximately 70% of Russians over the age of 45 are diagnosed with various diseases of the cardiovascular system. Such disappointing statistics are due to the fact that as arteries grow, the arteries narrow, resulting in increased blood pressure. As a result, the renin-angiotensin aldosterone system produced in the body begins to increase the already high blood pressure.

People at risk are obese and have high blood glucose, as this only complicates the course of the disease and can cause various serious complications. This is due to the fact that too high a concentration of renin hormone can lead to kidney damage and malfunction of the urinary system. In addition, the purification of blood and the removal of toxins and other dangerous elements are violated, as a result of which all harmful substances enter the bladder.

Arterial hypertension and increased renin level in the body

One of the most hard-working organs in our body are the kidneys. They are constantly functioning to the maximum, clearing about 1.5 tons of blood per day. With the narrowing of the blood vessels, the blood flow velocity increases significantly, which creates an increased load on the membrane shells. If treatment is not scheduled on time, it can lead to death.

If the renin-angiotensin system does not work properly, then a large number of toxic substances begin to enter the blood, which violate the potassium and water-salt balance. As a result, the kidneys and their cells are affected, which, in turn, causes the development of hypertension of varying severity.

Consequences in the absence of treatment

If there is no treatment for arterial hypertension for a long period of time, the patient may develop heart failure. The main reason for this is that the renin improperly performs its functions.

The primary symptoms of congestive heart failure are:

• muscle weakness;
• inflammation of the mucous membranes throughout the body;
• is a strong breath, even with small physical exertion;
• increased heart rate;
• violation of heart rate;
• numerous swelling caused by poor kidney function and delayed removal of fluid from the body.

If the patient is not assigned complex therapy, the disease will progress, and the condition of a person will be aggravated. In this case, not only the kidneys and adrenal glands will be affected, but also the liver. It increases in size and thickens, and the patient feels severe pain. If the renin-aldosterone system does not start functioning normally, then severe pathologies of other internal organs may occur, as well as the functioning of various systems. Too high level of this hormone in the blood can provoke non-alcoholic cirrhosis of the liver.

Refusal to drink alcohol

Without comprehensive treatment, drinking is very dangerous, since even a small amount of alcohol can cause complete liver failure. In addition, it is recommended to exclude fatty and spicy food from the diet, as it creates a greater burden on this organ, which negatively affects the course of the disease.

The patient has a strong shortness of breath, which tortures him not only with physical work, but also at rest. Therefore, it is recommended to eat only natural and healthy food, and also to abandon bad habits.

Low renin content in the body

If microbial renin is produced by the adrenal glands in insufficient amounts, then the level of aldosterone increases significantly. In this case, a violation of the synthesis of this hormone proceeds almost asymptomatically. That's why the problem can not be detected in time. The only manifestation is a sharp rise in blood pressure. The most common cause of this is adrenal cancer.

With a low level of the renin hormone in the blood, sodium is poorly excreted from the body, and potassium, on the contrary, begins to be excreted in large quantities. As a result, it is difficult to remove fluid and there are numerous swelling in the body, and the person begins to get tired more, even with little physical exertion. In addition, arterial hypertension develops, which is no less dangerous.

Conclusion

It will not be surprising for anyone that today, many simply do not have enough time to regularly monitor their own health. The human body has a rather complex device. Every day it produces a large number of hormones and substances, as well as a lot of biological and chemical processes. Violation of any of them, for example, insufficient or excessive development of the hormone renin, can lead to very serious consequences.

Therefore, it is necessary to treat your body very carefully. To live a healthy life and minimize the development of various serious diseases, it is recommended to visit a qualified specialist at least once every six months, adhere to the right diet, and also refuse any bad habits. It's very easy to spoil your health, but it can be impossible to return it.