Decapeptil: instructions for use, composition, indications and contraindications

How should I apply Decapeptil medication? Abstract on the use of this drug will be presented below. Also, you will learn about the indications for the use of this drug, its analogs, side effects and so on.

"Decapeptil": description of the preparation, its composition and form.

. The medicament in question is marketed as a clear and colorless injectable solution, which has no odor, and mechanical impurities.

The main component of this medication is tryptorelin acetate. In addition, it contains ingredients such as glacial acetic acid, sodium chloride and water for injection.

You can buy Decapeptil solution, the photo of which is presented in this article, in syringe-ampoules complete with injection needles, which are packaged in contour boxes and carton boxes, respectively.

Action of the drug( pharmacological)

What is the Decapeptil solution? Instruction for use reports that this is a synthetic analogue of GnRH, or the so-called gonadotropin-releasing hormone.

After the administration of this drug, its active substance causes an increase in the level of LH and FSH in the blood, which ultimately leads to a short-term increase in the concentration of sex hormones. Prolonged pituitary stimulation( for example, with regular use of the drug) promotes blockade of gonadotropic work. The result of this effect is the reduction in the number of hormones( sexual) to menopausal or post-stress. These effects are reversible.

Studies in laboratory animals showed no mutagenic or teratogenic effects of the drug in question.

Pharmacokinetics of the injectable preparation

What pharmacokinetic properties are characteristic for the Decapeptil solution? Instructions for use asserts that in the first 50-90 minutes after the administration of the drug, tryptorelin in the blood reaches its maximum. Further, the concentration of this substance is markedly reduced( throughout the day).

The half-life of the main component is 18.7 minutes. About 4% of tryptorelin is excreted along with urine in unchanged form.

It should be specially noted that pharmacokinetic tests of this medication have been performed in people with a confirmed diagnosis of uterine myoma or endometriosis, as well as in healthy male volunteers and patients with prostate carcinoma.

Indications for the injection of the injection solution

What is the purpose of the drug "Decapeptil"?Indications for the use of this solution for women are:

• uterine myoma;
• infertility therapy using reproductive technologies( eg, embryo transfer, IVF);
• endometriosis.

As for men, this remedy is recommended for symptomatic treatment of hormone-dependent progressive prostate carcinoma.

Prohibitions for the introduction of medicinal products for men and women

In what cases can not be administered Decapeptil solution? Instruction for use indicates that for women this drug is contraindicated:

• when breastfeeding;
• pregnancy;
• clinical manifestations or the risk of osteoporosis.

It should also be noted that with caution this drug is used in the implementation of the IVF program in patients with polycystic ovaries( that is, if the number of follicles that are determined by ultrasound is more than 10).

For representatives of the stronger sex, the medication in question is contraindicated:

• with surgical castration( preceding);
• prostate carcinoma( hormone independent).

A general prohibition on the administration of this drug is a patient's hypersensitivity to tryptorelin or to other components of the drug.

Decapeptil Solution: Instruction for Use

This medication is intended for subcutaneous administration. In endometriosis, prostate cancer and uterine myoma, the drug is administered in an amount of 0.5 mg / ml once a day for a week. From the 8th day, they switch to a maintenance dosage of 0.1 mg / ml once a day.

In the process of treatment with this remedy, ultrasound is carried out and the sizes of myoma and endometriosis foci are controlled.

When the IVF program is administered, the medication is administered according to protocols( may be ultrashort or short).In order to prevent post-injection reactions, the injection site is changed every time.

When should I use Decapeptil Depot solution? Instruction for use says that this remedy is indicated with a long course of therapy. It is also administered subcutaneously to the abdomen or intramuscularly once every 30 days.

The prepared solution is used immediately. With endometriosis and uterine myoma, the therapy is started in the first days of the cycle. Such treatment should last about 3-6 months. In prostate cancer, prostate therapy is also performed for a long time.

When carrying out IVF, the drug "Decapeptyl Depot" is administered once on certain days of the cycle.

Side effects

What are the undesirable reactions that cause Decapeptil solution? The instruction, the reviews report that the side effects manifested in the background of the use of the drug in question are due to a decrease in the number of sex hormones in the blood, which ultimately can lead to the development of symptoms such as depression, mood lability, frequent headaches, weakening of libido, sleep disorders, hot flashes, weight gain and increased sweating. In addition, in some patients the following changes were observed:

• obstruction of the urinary tract, paresthesia, pain during sexual intercourse;
• vision impairment, back pain, muscle weakness;
• in women - uterine bleeding and dryness of the vagina;
• in men - gynecomastia, decreased potency and decreased testicular size;
• nausea, redness of the skin, decreased appetite, itching;
• fever, hypercholesterolemia, bone pain caused by metastases;
• myalgia, spinal cord compression, anaphylaxis;
• arthralgia, pain at the site of medication, demineralization of bones( with prolonged use);
• enlargement of lymph nodes, thrombophlebitis, edema of the legs;
• loss of hair on the legs, chest and hands, reducing the growth of the beard.

It should be noted that all of these side effects disappear immediately after the end of the course of therapy.

Drug interactions, cases of overdose

No cases of overdose with the drug in question were observed. With the development of any negative signs against the background of exceeding the dose of the drug should be symptomatic treatment.

Drug Interactions Decapeptil with other agents was not established.

Special information for patients

The course of treatment with Decapeptil should be carried out under strict control of the level of sex hormones in the blood.

Women should conduct a study to exclude a possible pregnancy. During the use of the drug, it is inadmissible to use hormonal contraceptives, as well as preparations containing estrogens.

The patient should be warned that during the course of treatment with the drug in question, menstruation will be absent.

The use of this remedy in men can lead to a temporary deterioration in their condition. If you have negative symptoms, you should immediately contact a doctor.

Similar drugs

How can I replace the drug solution "Decapeptil"?Analogues to this drug are difficult to pick up, so this procedure should only be done by an experienced doctor.

According to some experts, the medicine in question can be replaced by the following means: "Zoladex", "Buserelin-Depot", "Diferelin", "Tryptorelin".

Reviews of the injection solution of

Currently, for the therapy of endometriosis and other diseases of the reproductive system, the most effective and effective are gonadotropin-releasing hormone agonists. These include drugs such as Decapeptil, Diferelin, Zoladex, and others. However, it should be noted that the high cost of such funds does not allow them to be widely used in medical practice. In this regard, there are not very many reviews about their application.

According to reports of specialists, the drug "Decapeptil" is especially often prescribed for the treatment of uterine fibroids( duration 5-6 months).This use of the drug led to a decrease in the volume of the uterus and the size of the nodes. Further operative intervention was carried out. Thus, treatment with "Decapeptil" was prescribed as preoperative preparation.

Many patients claim that after injecting a solution, they often had pain at the injection site, itching and redness. Also there were headaches, hot flashes, insomnia and fatigue.

Positive reports about this drug are often left by women who used Decapeptil according to the IVF protocol. Due to this drug in most cases, the procedure for embryo introduction into the uterus was successful. Of the side effects of the fairer sex noted hot flashes and sweating.