Tablets "Betmiga" 50 mg: instructions for use, reviews
"Betmiga" tablets belong to the group of selective β3-adrenergic receptor agonists. The medical drug affects the urinary system, in particular, smooth muscles. With regular use, muscle tone decreases. Tablets "Betmiga" 50 mg can be administered strictly under the supervision of the attending physician, on his recommendation. Self-medication has a high probability of getting complications. In pharmacies, the sale of the drug is permitted only if a prescription is available.
What are we talking about?
"Betmiga" belongs to a group of long-acting drugs. Each tablet is enclosed in a film shell, on which the symbols of the pharmacological company that produced the medicine are engraved. Tablets "Betmiga" 50 mg( 30 pieces in a package) are issued oval, convex on both sides. Dyed in a characteristic brownish color. In the package - one blister or several. Also, there is an instruction manual in the package "Betmiga" with recommendations of the manufacturer on the use of the medication.
The effectiveness of the reception is guaranteed by the presence of active substance mirabegron( completely synthetic).The use of the course makes it possible to achieve a relaxing effect on smooth musculature. The active component decomposes in the liver, is excreted through the kidneys.
When and why?
Usually, the drug "Betmiga" is prescribed 50 mg if the bladder activity is much higher than normal, when the patient notes that the urge to urinate is too frequent. If incontinence is observed, it is necessary to urgently consult a specialist. With such problems, it is often the doctor who prescribes "Bethmiga" 50 mg. At the same time, it is not allowed to choose a drug for treatment alone, without knowing all the features of the organism, without the information obtained from laboratory tests.
In the instructions for the use of "Bethmiga" 50 mg it is indicated that the medicine has a systemic effect, that is, it affects the whole organism, and not only the target organ. This imposes certain restrictions on its use and forces particularly careful attention to the list of contraindications.
The instruction on the use of "Betmiga" tablets mentions the impossibility of using the drug in childhood, with fetal bearing and breastfeeding. In addition, it is inadmissible to use "Betmiga" medication for kidney and liver diseases, including their insufficiency. Some people have increased sensitivity, intolerance to synthetic medications. This also imposes certain limitations on the possibility of therapy with the help of "Betmiga" tablets. The instruction contains a reference to a possible allergic reaction, manifested by a rash on the skin.
Accurate use - the guarantee of a good result
When studying the instruction for "Betmiga" 50 mg, you can see that in severe cases of kidney failure, medication is possible, but under the supervision of a doctor and with special attention to the patient's condition. Similarly, the agent is used in the case of unstable hypertension. Specific interaction with the isoenzyme CYP3A obliges with caution to use "Betmiga" tablets in combination with highly effective inhibitors of this compound.
It is known that the drug interacts with a number of other medicinal substances. About all of them there is a mention in the instruction to "Bethmiga" of 50 mg, but it is better to discuss this question with the treating doctor. Otherwise, the increased activity of the bladder can be superimposed on complications from the use of incompatible medications. One should not overlook the risk of developing an allergic reaction.
Side effects of
Reviews and instructions to "Bethmiga" 50 mg contain mentions of possible side effects. The manufacturer does not hide them, and many people using the medicine noted that they exhibited a greater or lesser degree of severity. At the same time, the probability of side effects is rather low, because the drug adapts to the human body, so that the correctly selected therapeutic course does not provoke complications.
If side effects do manifest, then the main positive quality of the drug - systemic - becomes a drawback. Negative effects extend to a variety of organs, internal systems. Predicting all possible manifestations is not always possible. This is evidenced by reviews about "Bethmiga" 50 mg.
Common side effects of
From the patients' comments on "Betmiga" it is possible to collect information about the following manifestations of negative effects:
- swelling lips, dyspepsia appears;
- hurt, joints become inflamed;
- swells, the skin is scratched in the perineum;
- tachycardia, heart palpitations;
- rash, swelling, redness on the skin;
- pressure jumps.
When carrying out laboratory monitoring of the patient's condition, hepatic enzymes can be detected. In addition, reviews of "Bethmiga" 50 mg indicate an increased risk of infectious diseases of the genitourinary system, cystitis.
What should I do?
As follows from the instruction on the use of tablets "BETMIGA" 50 mg, if any of the listed signs are fixed, it is necessary to urgently contact the attending physician and stop taking the medication. Typically, the doctor chooses an alternative.
In some cases, it is sufficient to adjust the dose. This measure is applicable if the cause of intolerance, side effects in the improper, inadequate functioning of the kidneys, liver. It is known that in other cases, a reduction in the dose relative to the recommended dose does not allow achieving a long lasting positive effect.
How to use?
Reviews of the tablets "Bethmiga" 50 mg contain recommendations to take the drug orally, there is no need to adjust to the schedule for eating or sleeping. Many patients agree that it is more convenient to develop an individual convenient schedule for themselves and use tablets at the same time every day.
It is recommended to take a dose of 50 mg at a time, but it is possible to halve if pathological disturbances in the kidneys and liver are diagnosed. Tablets are plentifully washed down with water. The duration of intensive therapy is determined by a doctor who is guided by the characteristics of the disease. In some cases it is enough to drink, observing the instructions for use, tablets "Betmiga" 50 mg a couple of days. With more serious health problems, the duration of the course increases to a week or even a month. In this case, the patient's condition is regularly monitored, tests are taken to fix the indicators in the laboratory, on the basis of which they decide to complete therapy or prolong course. Independently interrupt the treatment with tablets "Betmiga" 50 mg instructions for use categorically prohibits. This not only reduces the therapeutic effect to zero, but it can also provoke complications.
Can I replace?
If the patient needs therapy, but "Betmiga" is not applicable due to contraindications, individual intolerance or other reasons, it will be necessary to resort to analogues."Bethmiga" 50 mg can be substituted for some medications, but which ones are decided by the doctor, assessing the patient's condition.
Often the need to replace a medicine is provoked by a high price - one package containing 10 tablets costs about a thousand rubles. Inexpensive drugs with a similar effect in the pharmacy are presented in a fairly large variety, but the choice should be discussed with the doctor, since each drug has its own restrictions on use, contraindications and side effects.
The list of analogues
Reviews: believe it?
Information from patients treated with Betmig tablets 50 mg( according to the instructions for use) is generally positive. People note that the use of a medicament under the supervision of a specialist and with all the conditions specified by the manufacturer gives good results.
At the same time, the total number of reviews in the Russian-speaking sector of the Internet is small. Presumably, this is due to the high cost of the medication. People are eager to save, so they prefer cheap analogs. Often, doctors immediately prescribe prescriptions for "Betmiga" tablets and an alternative, inexpensive option.
"Betmiga": important features of
It is not recommended to use the drug( and this is indicated in the instruction on the use of 50 mg BETMIG tablets) at the childbearing age if the patient is a woman who does not prefer to use contraceptives.
With care, it is possible to apply a medication in the treatment of patients who have a QT interval extended from birth, or whether this deviation has appeared over the years. Imposes a certain restriction and therapy with medications provoking prolongation of QT.With great caution use the "Betmiga" pills if the patient is taking a course of tricyclic antidepressants or is treated for arrhythmia with drugs of group 1C.
"Betmiga" and pressure
It is known that taking a medication can provoke an increase in blood pressure. To avoid unpleasant situations, you need to regularly monitor the patient's condition. The usual practice is the following: make a control pressure measurement before the start of treatment, then regularly check the indicators already during the treatment with tablets.
Special attention should be paid to pressure indices if a person with already diagnosed arterial hypertension is on treatment.
We apply carefully
It is known that regular use of medication according to the instructions does not affect the psyche, motor skills, cognitive abilities. Therefore, it is possible to undergo therapy, at the same time manage the car, to work in potentially dangerous conditions. There are no restrictions.
Interaction with drug components
Mirabegron is a CYP3A inhibitor to a low degree, in a larger proportion, an inhibitor of CYP2D6.For this reason, the medication affects the transport of drug components through the P-glycoprotein( but only when a high dose is accumulated in the body).
The conducted studies showed that there are no expected clinically significant results of interaction with simultaneous application of "Betmig" and drugs inhibiting CYP, classified as substrates. The situation with carriers of isoenzymes is similar. The exception is CYP2D6: at high concentrations, mirabegron affects the metabolism of the compound.
If the liver, kidneys function normally, these effects are considered to be of little importance and do not affect therapy. With mild, moderate renal, hepatic insufficiency and the use of strong drugs based on itraconazole, clarithromycin and the like, the daily dose of "Betmiga" tablets should be reduced by half.
Very carefully, with regular monitoring of the patient's condition, use "Bethmiga" tablets in combination with drugs that affect the metabolism of CYP2D6, and also, if necessary, prescribe a digoxin to the patient. During treatment, regularly check the concentration of digoxin in the blood, if necessary, reduce the dose.
There are three dosage options available on sale: 5, 15, 30 mg. The drug is classified as an antispasmodic and is one of the most commonly used analogues of "Betmiga" tablets. Packing of 30 tablets costs from 350 rubles, which is about six times cheaper than the drug "Betmiga."The main component of the drug is called trospium chloride, is effective at the expense of the ability to block m-holinoretseptory. Spasmolytic additionally has a ganglion-blocking effect. The active component is an antagonist of acetylcholine.
The use of the drug blocks the detrusor, but there is no central effect on taking the tablets. The usual indication for the use of the drug is increased bladder activity, increased frequency of urination. The effectiveness of reception is given only for non-hormonal, inorganic causes of health problems.
The product can be used for incontinence of various forms, including mixed. Efficiency has been proven even in pathological disturbances of the functioning of the urinary system, expressed in increased activity, detrusor reflexion, provoked by trauma, stroke, sclerosis, Parkinsonism.
The drug is widely used in the treatment of cystitis.
The main contraindication is the intolerance of the main active component of trospium chloride. In addition, it is not recommended to use Spasmox if the patient has irregularities in the work of the heart, vessels, especially in cases of stenosis, hypertension, arrhythmia, and heart failure.
Very carefully using "Spazmex" is allowed if diagnosed:
- Down's disease;
- cerebral palsy.
The restriction also imposes a number of other health disorders, including significant pathologies of the kidneys and related organs, neuropathy. During fetal gestation, lactation of a ban on the use of medication is not available, but its use is undesirable.
Adverse events. Overdosing of
It is quite rare, but cases of dyspepsia are known, dry mouth is possible. Also, the share of the side effect probability from the side of the nervous system is not high, this is expressed by confused consciousness. Less than 1% of patients who underwent treatment with Spazmeks were confronted with the death of skeletal musculature. Cases of accommodation problems are also categorically rare( but there is a small chance of probability).
At excess of the prescribed doses, dry mouth and frequent palpitations are possible. In some cases, visual perception suffers, the skin blushes. To eliminate negative reactions, it is necessary to use m-cholinomimetics. With a severe degree of drug poisoning, urgent use of beta-blockers with constant pressure control is necessary.
How to use?"Spazmeks" drink before eating, drink plenty of water. The tablet can not be chewed, it disrupts normal processing in the digestive tract and lowers the effectiveness of the drug. The choice of dose remains with the attending physician, analyzing the patient's condition, the degree of disorder, concomitant therapy and background diseases that affect the characteristics of the drug.
As a rule, "Spazmex" is prescribed thrice a day, regularly, with a break of 8 hours between doses. On the day in total, the body should not get more than 45 mg. In some cases, an unauthorized correction of the regime is possible-a reduction in the dose relative to the prescribed tablet by half the tablet. This is possible if the state of health suddenly deteriorates. Increase at will is unacceptable, only a specialist can correct the dose upwards, justifying his decision. If there are problems with the functioning of the kidneys, the maximum daily dose is reduced to 15 mg. The average course duration is three months.
Features of application and storage
The main active component of Spasmox activates quinidine, and also affects the effectiveness of tricyclic antidepressants. In addition, interaction with amantadine, antihistamines, and adrenostimulants is known.
If it is necessary to use "Spasmox" in people with problems with the functioning of the sphincter, detrusor, a catheter is required. If the bladder has vegetative shortcomings, it is important to identify the cause of the problem before starting treatment, only then prescribe the drug. Also, before the start of treatment, it is necessary to exclude the possibility of carcinoma, infections.
From pharmacies the product is released strictly if a prescription is available. At home, store the medication recommended in a place protected from light, cool( 15-25 degrees).It must be ensured that there is no access to the drug in children.
"Driptan" is considered to be effective, almost indispensable drug in children's enuresis, since its use is allowed from an early age. On sale tablets are presented in packages of 30 and 60 pieces. Packaging of 30 tablets costs about 700 rubles, which is approximately three times cheaper than "Betmiga."
The preparation is issued biconcave round tablets without special coloring( white).One side is marked with a risk to divide the portion into two.
The main active component of the drug is oxybutynin hydrochloride. In one tablet contains 5 mg. Additional substances contained in the preparation - calcium stearate, cellulose, lactose.
The agent is classified as an antispasmodic. Oxibutinin effectively relaxes smooth muscles. The substance is opposite in its effect to the effect of acetylcholine, which also positively affects the muscles, eliminating spasms. The highest activity of Driptan is in detrusor. Due to the relaxing effect, the agent smoothes the unpleasant consequences of instability and increased activity of the bladder. Regular use under the supervision of a doctor eliminates spontaneous contractions, the bladder becomes somewhat larger in volume.
When possible? And when it is impossible?
"Driptan" is suitable for adult patients and children with urinary incontinence, too frequent urge to urinate. Effective in idiopathic dysfunction and causes of a neurogenic nature. Often appointed at night incontinence, provoked by increased detrusor activity.
The remedy can be prescribed from the age of five. Children under the age of five years are strictly not recommended, as the likelihood of a negative side effect on the central nervous system and the psyche is high.
In addition to age there are a number of contraindications, forcing to use the medication with great care or completely refuse to take it. These are:
- hypersensitivity to the components of the drug;
- dysfunction of the esophagus;
- high temperature;
- closed angle glaucoma;
- pyloric stenosis;
- atony, intestinal obstruction;
- problems of carbohydrate metabolism;
- deficiency of lactase;
- myasthenia gravis.
Special control requires the reception of "Driptan" in case of failures in the liver, kidneys, esophagus.
In general, Driptan is a fairly mild drug, but side effects are still possible. The instructions for use of the drug mention:
- craving for sleep;
- dry skin;
- dry mouth.
Possible urinary retention. Mark the drier mucous organs of vision. In rare cases, taking the drug provokes vomiting, allergic reactions are possible. With long-term admission, normal saliva production is disrupted, the likelihood of caries increases.
How to use?
In childhood, "Driptan" is prescribed twice a day for half a tablet. With good tolerability, the dose may be taken at one time at night. The duration of the course is controlled by a doctor.
Exceeding the permissible doses can lead to negative reactions from the nervous system, pressure, respiratory system. The most severe outcome of an overdose is coma.