Arutimol eye drops: instructions for use, analogues, reviews

Are eye drops Arutimol effective? Negative reviews and positive reports about this drug will be presented at the very end of the article. Also, you will learn about the purpose of this medication, whether it has substitutes and contraindications.

Composition and Description

What is a local medication such as Arutimol( eye drops)?The reviews say it is a clear( 0.5% or 0.25%) colorless solution( maybe with a yellowish tinge) that has no odor.

The main component of this agent is timolol hydro-maleate. Also in the composition of the drops are such auxiliary elements as benzalkonium chloride, disodium edetate dihydrate, povidone, dihydrate sodium dihydrate, water d / and sodium dodecahydrate monohydrogenphosphate.

In the sale of the drug "Arutimol"( eye drops), the instruction of which is in a pack of cardboard, comes in polyethylene bottles.

Pharmacology of a local medicine

What properties are inherent in the drug Arutimol? Eye drops, the instructions for use of which will be described below, are actively used as an antiglaucoma agent, as well as a non-selective beta-1 and beta 2-adrenergic blocker.

This preparation does not show internal membrane-stabilizing and sympathomimetic activity. At local use, eye drops reduce normal and increased eye pressure. This is due to a decrease in the process of formation of intraocular fluid.

It should also be noted that the use of this medication has no effect on accommodation and the size of the pupil.

The action of this remedy is manifested 20 minutes after the installation in the conjunctival sac. As for the maximum decrease in intraocular pressure, it is observed after 65-115 minutes and persists throughout the day.

Kinetics of the local preparation

Is the drug "Arutimol"( eye drops) absorbed? The instruction states that with local use of timolol maleate undergoes systemic absorption only to a small extent. After instillation of the drug, the maximum concentration of this substance in the aqueous humor of the anterior chamber of the optic organ is reached after 60-100 minutes.

In a small amount, the medicament in question enters the systemic bloodstream by sucking through the vessels of the conjunctiva, the lacrimal tract and the mucous membranes of the nasal cavity. It is excreted by the renal system in the form of metabolites.

In young children and newborn babies, the highest concentration of timolol in the blood exceeds the above value in the plasma of adult patients.

Indications

At what diseases is the patient prescribed the drug "Arutimol"( eye drops)?The instruction reads about the following indications for the use of this remedy:

• glaucoma open-angle;
• increased intraocular pressure, or so-called ocular hypertension;
• glaucoma secondary, including aphakic;
• congenital glaucoma( used for inadequate efficacy of other therapeutic measures);
• glaucoma is closed-angle, including in combination with miotics( in the form of an additional drug to reduce ocular pressure).

Contraindications

In what cases is it forbidden to use eye drops "Arutimol"?From the infant hemangioma they help very well( applied locally three times a day), but they can not be used with:

• AV blockade of III or II degree;
• obstructive airway diseases of a chronic nature, including bronchial asthma;
• heart failure, taking place in a severe stage;
• sinus bradycardia;
• corneal dystrophy;
• cardiogenic shock;
• allergic reactions accompanied by generalized skin rashes;
• severe atrophic rhinitis;
• hypersensitivity to timolol and other elements of a local medication.

With caution, this remedy should be given to people with pulmonary insufficiency, chronic heart failure, severe cerebrovascular insufficiency, thyrotoxicosis, diabetes mellitus, myasthenia gravis and hypoglycemia, as well as in parallel with other beta adrenoblockers.

Preparation "Arutimol"( eye drops): instruction

In what dosage is the medication prescribed for patients? According to the instruction, this preparation is used in the amount of one drop( 0.5% or 0.25% solution) twice a day. After stabilizing the pressure, this dose should be reduced to one drop per day.

How should I use eye drops Arutimol? How to apply them at home? Experts argue that for effective therapy, the medication in question should be instilled in the conjunctival sac( lower) of the affected organ alone.

It should also be noted that this drug is intended for prolonged use. Thus the patient should be necessarily warned that a break in the use of the medication or a change in the recommended dosage can be carried out only on the recommendation of the doctor.

Side effects of

Now you know what is needed for the drug "Arutimol"( eye drops)?Instructions, analogues of this medication are presented in the article.

Specialists claim that the application of the agent under consideration can cause the following side effects:

• heart failure, eczema, collapse, bradycardia, urticaria;
• irritation, decreased blood pressure, AV blockade, dizziness, cardiac arrest, hyperemia of the skin of the eyelids and conjunctiva, depression, pulmonary insufficiency;
• itching and burning in the eyes, dyspnea, bradyarrhythmia, lacrimation, headache, photophobia;
• paresthesia, corneal epithelial edema, bronchospasm, superficial point keratopathy, weakness, transient cerebral circulatory disorders;
• corneal hypostension, diarrhea, diplopia, nausea, ptosis, rhinitis, dry eyes;
• retinal detachment in postoperative time, violation of sexual functions, apnea in newborns, alopecia.

Cases of overdose

What signs of overdose can occur when using a large amount of the drug in question? According to the instructions, eye drops used in high doses can cause dizziness, arrhythmias, headaches, bradycardia, nausea, bronchospasm and vomiting.

To eliminate such phenomena, experts recommend washing eyes with saline or ordinary water. If necessary, you can carry out symptomatic treatment.

Drug interaction

How does the drug in question when it is combined with other drugs?

The combined use of Arutimol with eye drops containing epinephrine can cause a significant dilatation of the pupil.

Reduction of blood pressure, as well as slowing of the heart rate are often observed with the joint application of local remedies with calcium channel blockers and beta-blockers.

Reduction of eye pressure is enhanced by the parallel use of drops that contain pilocarpine and epinephrine.

Simultaneous use of the drug with hypoglycemic agents for oral use and insulin can lead to the development of hypoglycemia.

Timolol significantly enhances the therapeutic effect of muscle relaxants.

Special Information

Before prescribing the medication in question, the patient should be warned about the need to visit the doctor regularly to measure eye pressure and examine the cornea.

If the patient wears soft contact lenses, then the drug "Arutimol" is contraindicated to him, since the preservative contained in the solution can be deposited in the lenses and adversely affect the tissues of the visual organs.

With regard to hard contact lenses, the interval of ¼ hour should be observed before instillation of the medicament and their re-installation.

Before the forthcoming surgical intervention with general anesthesia, instillation of "Arutimol" should be stopped exactly in two days.

It is strictly forbidden to use two beta-blockers at the same time.

Eye drops "Arutimol": customer reviews and analogues

For acute need this medication can be replaced with such drugs as Teobrazone, Timolol, Normaks, Stilavit, Floxal and others.

Most patients who use eye drops "Arutimol" are satisfied with their action. They argue that this remedy cures such diseases of the visual organs as glaucoma( open-angle, congenital, secondary and occlusive).Moreover, the use of this drug effectively reduces the increased eye pressure and relieves the so-called intraocular hypertension.

As for negative messages, most often they contain information about the development of a large number of side effects, including those from the organs of vision and the respiratory system.