The drug "Acyclovir-AKOS"( tablets).Instructions for use for children and adults, reviews
In what dose do you prescribe the medicine "Acyclovir-Acos"?Instructions for the use of these tablets will be presented below. Also, you will find out about what this remedy is used for, whether it has side effects and contraindications, what is included in its composition, and in what packaging it goes on sale. 
Composition, description, packaging of medicinal product
What components does Acyclovir-Acos( tablets) contain? Instructions for use say that the active ingredient in this medication is acyclovir. It also includes additional ingredients in the form of talc, magnesium stearate and potato starch.
"Acyclovir-Acos" - tablets( patient reviews will be described below) flat-cylindrical white with a risk and facet. In the sale of the drug comes in contour cells, which are placed in cardboard packages. Also, this medicine can be found in banks of dark glass.
Pharmacological properties of the drug
How does "Acyclovir-Acos"( tablets) work? Instruction for use states that this antigipertic antiviral agent. This preparation is a synthetic analogue of a purine nucleoside. It is able to inhibit the replication of viruses of herpes simplex, cytomegalovirus, as well as Epstein-Barr viruses and Varicella zoster.
Features of the drug
According to specialists, "Acyclovir-Agos", whose reviews are more positive, shows good activity against the viruses that cause shingles and chicken pox.
After taking the medication in infected cells, phosphorylation begins. Acyclovir is converted to acyclovir monophosphate. Under the influence of guanylate cyclase, the latter turns into a diphosphate, which, in turn, is converted to triphosphate. 
The selective effect of the preparation on viruses, as well as its low toxicity for the body, are due to the fact that its active substance does not represent a substrate for the enzyme thymidine kinase. In this regard, it is not toxic to mammalian cells.
After the conversion of acyclovir to acyclovir triphosphate, it inhibits the synthesis of DNA from virus 3 by mechanisms:
- replaces deoxyguanosine triphosphate;
- is inserted into the DNA chain, and then stops its elongation;
- has a depressant effect on herpes simplex DNA, etc.
As a result of this effect, the reproduction of the virus stops.
The effectiveness of acyclovir is also due to its accumulation in cells that are already infected with the virus. With herpes, the drug prevents the formation of new rashes, as well as accelerates the healing of wounds, reduces pain and has an immunostimulating effect.
Pharmacokinetic parameters of anti-herpetic tablets
Where is the absorption of the drug "Acyclovir-Acos"?Instructions for use informs you that after ingestion, it is absorbed in a small amount from the intestine. At the same time, concentrations( dose-dependent) are formed, which are quite sufficient for the effective treatment of viral diseases. 
Food has virtually no effect on the absorption of the active substance. With an increase in the dose, the bioavailability of the medicament decreases.
The maximum concentration of the drug after its administration inside in the amount of 200 mg 5 times a day is 0.75 μg / ml, and the minimum concentration is 0.45 μg / ml. These values are noted after two hours.
With plasma proteins, the active substance binds to 10-35%.It penetrates the blood-brain barrier, as well as almost all tissues and organs( lungs, brain, lacrimal fluid, kidneys, intestines, liver, muscles, watery moisture, breast milk, semen, spleen, amniotic fluid, uterus, secret and mucous membranevagina, as well as the contents of herpetic vesicles).
The drug is metabolized in the liver. A metabolite, called 9-carboxymethoxymethyl guanine, is formed.
Drug is withdrawn through the kidneys( 62-91% of the dose) and through the digestive tract. Also trace amounts of medication are determined in the air exhaled by the patient.
When taking the drug inside its half-life( in adult people) is - 3.4 hours, and in children( 1-18 years) - 2.4 hours. Thus, it can be safely noted that the rate of excretion of the drug slows down with age. 
Indications for use of medication
When is Acyclovir-Acos prescribed? The use of this drug is indicated for the prevention and treatment of infections that are caused by the viruses Varicella zoster and Herpes simplex( 2 and 1 types).Thus, this drug effectively fights against:
- simple herpes on the skin and mucous membranes( recurrent and primary);
- by shingles;
- genital herpes( primary and recurrent);
- herpes zoster;
- chicken pox( the first day after the appearance of the rash).
It should also be noted that this drug is actively prescribed to patients with severe immunodeficiency( for example, in HIV-infected people, after transplantation and during the reception of immunosuppressive medications).
Contraindications to the use of
In what cases is it forbidden to apply "Acyclovir-Acos"( tablets)?The instruction indicates the following contraindications:
- children's age( up to three years);
- hypersensitivity to the active substance, and also to valaciclovir.
With special care, this medication is prescribed for pregnancy, kidney failure and dehydration, as well as during breastfeeding. 
The drug "Acyclovir-Acos": how to take adult people?
Tablets should be taken orally, regardless of food, with a glass of plain water.
Adults for treatment of herpes simplex on the mucous membranes and skin are prescribed 200 mg of the drug five times a day. Take the medicine every four hours( except for sleep).
Usually the duration of therapy with such a drug is five days. But if necessary, it can be prolonged( according to the doctor's recommendations).
In the treatment of people with immunodeficiency, a single dosage of the drug is increased to 400 mg, and the duration of the course is up to ten days or more.
Adult patients with genital herpes are recommended to take 200 mg of the drug five times a day( every four hours) for 10 days( if necessary, therapy can be extended).Treatment should be started as soon as possible after the first signs of infection. If there are relapses, then the drug is prescribed already in the prodromal period.
To prevent the recurrence of infections that were caused by the herpes simplex virus, medication is prescribed at 200 mg four times a day( every six hours).People with normal immunity can use the drug in the amount of 400 mg twice a day( every 12 hours).When the immunodeficiency is expressed, the dosage remains the same, however, the frequency is increased up to five times a day. 
Genital herpes relapsing( less than six times a year) requires compliance with the following treatment regimen: 200 mg five times a day for five days. If the episodes repeat more than six times a year, then the patient is prescribed 400 mg of the drug twice a day for 12 months. The duration of prevention is usually determined by the duration of the period when there is a risk of infection.
When treating herpes zoster or depriving a patient, 800 mg of the drug is prescribed five times a day( every four hours) for 7-10 days.
The maximum single dose of this medication is 800 mg.
People taking an increased dose of the drug should receive a large amount of fluid.
"Acyclovir-Acos"( tablets): instruction for children
Babies, whose age has reached three years, this medication should be prescribed only by experienced pediatricians. Typically, dosages for them are similar to those for adults.
To treat chicken pox, children over six years of age are given 800 mg of the drug four times a day, and a child aged 3-6 years - 400 mg four times a day. For more accurate dosage, doctors use the following formula: 20 mg per kg of baby's weight. Take medication more than 800 mg four times a day is prohibited. 
The duration of therapy in small patients is five days.
People with impaired renal function require dose adjustment, as well as receiving frequencies. It depends on the type of infection and the amount of creatinine clearance.
Side effects after taking
tablets. Medicament "Acyclovir-Acos" very rarely causes side effects. But, according to the instruction, they still have a place to be.
- Nausea, increased bilirubin, diarrhea, abdominal pain, vomiting, reversible increase in liver enzyme activity.
- Acute renal failure, increased levels of creatinine in the blood and urea.
- Leukopenia, anemia, thrombocytopenia.
- Headache, hallucinations, neurological disorders reversible, confusion, dizziness, paresthesia, drowsiness, coma, convulsions.
- Rash, dyspnea, photosensitivity, angioedema, urticaria, fever, itching, lymphadenopathy, anaphylaxis, agitation, visual impairment, peripheral edema, myalgia.
- Rapid fatigue, alopecia.
It should also be noted that in people who receive antiretroviral drugs, the addition of the drug "Acyclovir-Acos" does not cause a significant increase in toxic effects. 
Special recommendations for the use of the anti-herpetic drug
What should I know before taking Acyclovir-Acos( tablets)?The instruction says that prolonged or repeated treatment of people with a decreased immune status can lead to the formation of strains of viruses that are insensitive to its action.
No clinical studies have been conducted on the safety of the use of this medication during pregnancy. In this regard, the use of the drug "Acyclovir-Acos" is shown only in those cases when the possible benefit for the mother significantly exceeds the possible risk to the fetus.
In the process of treatment with high oral dosages, the patient should drink enough water.
During breastfeeding, medication is prescribed only in extreme cases and a short course. This is due to the fact that the drug in small amounts penetrates into breast milk.
Medication "Acyclovir-Acos" does not prevent the transmission of herpes by sexual route. In this regard, during the period of treatment, the patient should refrain from sexual intercourse. 
Patients' comments about the drug
Now you know how and for what purpose the drug "Acyclovir-Acos" is prescribed. Instructions for use of this tool have been described in detail above.
According to the reviews of most patients, the drug in question effectively manifests itself in herpetic rashes. If you take the pill immediately after finding the first signs of herpes, then the patient's recovery comes much faster.
It should also be noted that "Acyclovir-Acos" effectively cures shingles and chicken pox.
In addition to therapy, this medication is often used as a preventive agent. Its correct reception helps to reduce the number of relapses to a minimum. 
The price of medicinal product
Also it should be said that besides high efficiency the medicine "Acyclovir-Akos" pleases patients and its rather low cost. You can buy 20 antiherpetic tablets for 30-40 Russian rubles. This amount is enough for the whole course of treatment.
By the way, analogues of this medicine possess the same low price.