Duhringa dermatitis: causes, symptoms, diagnosis and treatment features
What is Dühringa dermatitis? The answer to this question you will get from the materials of the article in question. Also, you will learn how to treat such a disease, what are its symptoms and the causes of its occurrence.
Dulinga dermatitis is a pathology that belongs to the dermatitis group and is classified as herpetiform. This group combines skin diseases, which develop for various reasons, but have the same clinical picture.
Like other dermatoses, Dühringa dermatitis is characterized by the appearance of a specific rash. This pathology is not uncommon. Any person at any age can interfere with it. The name was given to the disease by the name of the Philadelphia doctor - Duhring. As you know, he studied it in the late 19th century.
Causes of development of
Why does Diuringa dermatitis occur? The true cause of the development of such an ailment has not yet been established. However, experts put forward several theories that justify the occurrence of this unpredictable skin disease.
Scientists have 3 triggering factors:
- reduced human immunity, which ultimately leads to weak and unstable resistance of the body to infection;
- genetic predisposition;
- problems of the digestive system, or rather a violation of the absorption of nutrients in the intestine.
Herpetiform dermatitis of Dühring, the treatment of which will be described below, refers to skin autoimmune diseases. Therefore, in the process of therapy, most doctors develop schemes that correspond to the algorithm for treating autoimmune disorders.
It should also be noted that in some patients gluten intolerance is detected in the survey, in excess contained in cereal crops. The autoimmune origin of this disease is indicated by the fact that IgA antibodies are often found between the epidermis and the dermis.
Also it should be said that the development of such a dermatosis is capable of provoking inflammatory processes in the gastrointestinal tract, viral pathologies, increased iodine sensitivity and ascariasis.
Symptoms As with any skin disease, the disease under consideration is easily recognized by external symptoms. Usually it affects the stronger sex at the age of 22-38 years. As for women, such dermatosis does not affect them very often.
The main symptoms of this disease are the following abnormalities:
- Rashes on the skin that take the form of vesicles with fluid inside. During the development of the disease, such blisters are opened, and in their place crusts are formed. When combing, the bubbles burst much faster. At the same time, their contents can reach the healthy skin and infect it, which will trigger the formation of new rashes.
- Itching, soreness and burning in the place of rash. This condition forces the person to scratch the problem area, which entails a significant increase in the surface of the rash.
- With Dühring's dermatitis, there is an itching first, and then the first blisters are observed.
- Problems with the intestinal tract in the patient are expressed by the fat content of the stool, which subsequently acquires a gray color.
Other signs of skin disease
Externally considered disease manifests itself only in the deterioration of the general well-being of the patient, his emotional nervousness or retardation, as well as changes in body temperature.
Bubble elements that arise during the development of this disease are small. In this case, they are called vesicles. If they are large( diameter of 2 cm), the doctors call them bullous rashes.
According to experts, if the fluid contained in the blisters, eventually becomes turbid, it means that the pathological process was joined by an infection.
It should also be noted that combing the already formed crusts very soon leads to the formation of an erosive site, which takes the place of the former bubble.
How to identify the disease in question? What are the diagnostic protocols? Duhring's dermatitis is quite easy to determine. For this, laboratory and instrumental methods are used. These include the following:
- Determination of the number of eosinophils in the blood, as well as in the vesicle fluid( they are significantly increased in case of disease).
- Thyroid examination( in almost 30% of all cases, various abnormalities are detected).
- Direct immunofluorescence, detecting the accumulation of fixed immunoglobulins A.
- Test with iodine. This diagnostic procedure is carried out as follows: on the forearm impose an ointment containing 50% potassium iodide, which is left for a day. With a positive sample, rashes and redness appear in this place.
Treatment of Duhring Dermatitis
Before starting treatment for patients with Duhring's dermatitis, carefully examine for gastrointestinal and malignant neoplasms. They are also prescribed Dapsone. Its dosage is 100 mg twice a day for 5 days with a 2-day break( 3-5 cycles each).
After the disappearance of signs of the disease, this medication is prescribed in a maintenance dose, that is, 5 mg every other day or twice a week. Side effects of this drug include nausea, vomiting, anemia, psychosis, liver damage and allergic reactions. It should also be noted that the drug "Dapsone" is incompatible with barbiturates and "Amidopirinom."
In addition to the mentioned drug, such drugs as lipoic acid, sodium dimercotopropanesulfonate, antihistamines, etebenecid, methionine, vitamins( rutozide, ascorbic acid, B vitamins) are also used to treat dermatosis.
Nutrition of the patient with the disease
How else to treat Duhring's dermatitis? Diet in this disease is mandatory. Patients are shown a diet with the exception of oats, wheat, millet and barley, as well as other cereals. In addition, patients with Dühring dermatitis are prohibited from eating products that contain iodine( eg, sea fish).
Prognosis and course of the disease
The course of the disease under consideration is cyclic and prolonged. As a rule, it is accompanied by incomplete and short-term remissions. Although some patients still observe complete and independent remissions.
In the process of treating Dühring's dermatitis, new rashes may appear in the patient. However, this condition is not an indication for a change( including an increase) in the daily dosage of the drug.
In most patients suffering from skin diseases, strict adherence to diet contributes to a significant improvement in the condition. However, this does not reduce the need for a Dapsone drug.