Kombizpasm tablets: instructions for use, composition, testimonials
Spasms are called involuntary contractions of the muscles, which are often accompanied by aching and sharp pain. Specialists distinguish several types of such seizures. These include spasms of skeletal or striated muscles( for example, in case of paralysis) and smooth muscles, that is, vascular walls( for example, in angina pectoris).
The first type of seizures impedes the movement of a person, and the second - disrupt the functions of internal organs.
To get rid of the pain, and also to restore your condition, doctors recommend using a drug such as Kombizpazm. Instructions for use, indications, doses and contraindications for this medication are given below.
Composition of the drug, its description, form of production and packaging
In what form do they purchase the drug "Combizpasm"?Instructions for use say that this product is available in the form of tablets without shell. They have a round shape, white color and risk.
The composition of the drug under consideration includes paracetamol, magnesium stearate, dicycloverine hydrochloride( i.e., dicyclomine), corn starch, methylparaben, talc, povidone, sodium starch glycolate, propylparaben and colloidal silicon dioxide.
The medication "Kombizpazm", the instruction for which is enclosed in a box of heavy paper, is packaged in blisters of 10 tablets.
The effect of the drug( pharmacology)
What effect does the drug Kombizpasm have on a person? Instructions for use, the description report that this is a combination medicine that has antispasmodic and analgesic effects. In addition, this medicine has antipyretic, myotropic and anticholinergic effects.
Paracetamol is a classic non-steroidal anti-inflammatory drug. It has analgesic and antipyretic properties. This component inhibits the synthesis of prostaglandins, and also reduces the intensity of their effect on thermoregulatory centers, which are located in the hypothalamus( brain).
As for dicyclomine, it also eliminates spasms of smooth muscles and reduces the intensity of pain. Similarly to paracetamol, this ingredient has a myotropic, antispasmodic and anticholinergic effect.
What role does dicyclomine play in the preparation "Combibispasm"?Instructions for use( the composition of this medication was presented above) reports that this component acts according to 2 different principles:
- Similar to atropine when it acts on acetylcholine or cholinergic receptors.
- Direct influence on smooth muscles. This ingredient blocks spasms induced by bradykinin and histamine, as well as painful syndromes, relieves spasms of the digestive tract, reduces the secretion of bronchial, salivary, gastric and sweat glands.
It should also be noted that when combined with paracetamol, the activity of dicyclomine is significantly increased.
Kinetic features of
What are the kinetic characteristics of the "Combispasm" preparation? Instruction for use informs that after taking the drug inside its active ingredients are quickly absorbed into the digestive tract and enter the systemic bloodstream.
The peak concentration of this drug in the blood is reached after 35-65 minutes. About 10% of the drug binds to plasma proteins.
In liver tissues, paracetamol undergoes metabolic reactions and is also oxidized by the cytochrome P450 system. 
The elimination half-life of the substance in question is 120 minutes. It is excreted through the kidneys.
Dicyclomine reaches its maximum level in the blood after 65-125 minutes after administration. The half-life period is 1.9 hours. Approximately 70% of this component is excreted together with urine, and the rest - through the digestive tract.
Indications for taking
In what cases is the "Combizpasm" medication prescribed? Instructions for use( tablets - this is the only form of this drug) claims that this remedy is prescribed for pain of various origins:
- with radiculitis, rheumatism and neuralgia;
- for muscle, headache, or toothache;
- for relief of menstrual pain and renal colic.
Contraindications to the use of
Does the medicine Kombizpazm have contraindications? Instructions for use( tablets for pain of various origins should be prescribed only by an experienced doctor) reports that this remedy is prohibited for use with:
- glaucoma, alcoholism, bile duct obstruction;
- at the age of up to seven years;
- anemia, myasthenia gravis, leukopenia and tachycardia;
- blood diseases, severe disorders in the work of the liver and kidneys;
- pregnancy;
- allergies to drug components;
- Hyperbilirubinemia( congenital);
- deficiency of the G6PD enzyme;
- breastfeeding;
- obstructive diseases of the digestive tract;
- stomach ulcer and 12-colon;
- delayed urination, which is observed with benign prostatic hypertrophy;
- of intestinal obstruction.
The preparation "Combizpasm": instructions for use
Tablets, the price of which is indicated below, should be taken orally, washed down with plain water. The treatment regimen and dosage regimen should be determined by the doctor.
For children from 15 years and adults this drug is prescribed one to two tablets once or four times a day.
Treatment is started with four tablets a day. In a day this medicine can be taken no more than eight pieces( in the absence of adverse reactions).
For children aged 7-13 years, the prescribed medication is prescribed one tablet a day( divided into two doses), and at the age of 13-15 years - up to three tablets per day.
The duration of therapy with this drug is determined on an individual basis.
If improvement has not occurred within two weeks after the beginning of the treatment or if undesirable side effects have appeared, the medication should be discontinued. 
Side effects of
The drug "Combizpasm", the instruction for which was described above, is well tolerated by patients. The development of undesirable side effects can be associated only with the uncontrolled and prolonged use of the drug.
The patient may develop:
- rashes on the skin, decreased appetite, hyperemia, vomiting, redness of the skin;
- increased gassing, paresthesia, nausea, urticaria, nervousness, diarrhea;
- drowsiness, constipation, numbness of body parts, impaired sensation;
- dizziness, bradycardia, emotional and psychomotor agitation, arrhythmia, speech disorders, increased sweating, confusion;
- tachycardia, impaired orientation in space, increased heart rate;
- hypoglycemia, stomach pain, general weakness, toxic effects on the liver;
- muscle weakness, glomerulonephritis, renal colic;
- anorexia, dry skin and mucous membranes, asphyxia, a violation of taste, nasal congestion, apnea and hyperemia of the throat.
Also rarely occur:
- nephrotoxic action, hemolytic anemia, pancytopenia, bronchial obstruction, neutropenia, urinary incontinence, aplastic anemia;
- thrombocytopenia, papillary necrosis, leukopenia;
- Stevens-Johnson syndrome, methemoglobinemia, toxic epidermal necrolysis, loss of consciousness, anaphylactic reactions, impotence, Quincke's edema.
Due to the presence of dicyclovirin in the patient, the patient may experience an increase in intraocular pressure, a dilatation of the pupils and an increase in sensitivity to light. Also paralysis of accommodation and mydriasis is possible.
The price of the medicine and its analogues
How much does the drug "Combibaspism" cost? Instructions for use( the price of this medication will be indicated right now) does not answer this question. You will learn it only in the pharmacy.
The cost of 10 tablets of the medicine in question is about 100 rubles.
If required, it can be replaced with medications such as Trigan-D, Diklo-p, Bolo-ran Neo, Cefekon, Sedalgin Neo, Solpalgin, Dolaren, Caffetin"," Novalgin "," Spasgo "," Dollar "," Sigan-DBS "," Apap "," Solpadein "," Solpadein "," Yunispaz "," Paracetamol ".
Customer Reviews
Now you know how the "Combizpasm" medication works. Instruction, application, feedback about this tool are presented in this article.
Most consumers claim that the drug in question manifests itself as a highly effective antispasmodic and analgesic. It helps to cope with pain of various origins, including that manifested during menstruation in women. Also this medicine quickly eliminates headaches. 
In addition to high efficiency, the advantages of this drug include its availability( sold in virtually every pharmacy), as well as a relatively low cost.
As for the flaws, they also take place. Some patients complain of excessive toxicity of the drug, a feeling of numbness of the tongue and problems with the organs of the digestive tract.