The drug "Fermatron": reviews of patients
Inflammations of joints and concomitant diseases are frequent ailments. There are several types of drugs used for treatment, among them - "Fermatron."The patients' comments about this medicine show that it really copes with the task set before it - it really improves the mobility of joints and relieves pain in them. In the article the questions concerning this preparation are considered.
"Fermatron": description
The Latin name of the drug is FERMATHRON.It is a viscous-elastic substance, which is intended for injections into the synovial space of the joint. It is shown in a disease called "osteoarthritis of large joints", caused by posttraumatic and degenerative changes. 
In the production of this preparation, new technologies for synthesis and purification have been used. Thanks to this, the medicine contains the equivalent of natural human hyaluronan. The substance acts in the following directions:
- restoration of visco-elastic and protective properties of the joint fluid;
- reduction of inflammatory reactions in the joints;
- joint repair;
- elimination of pain syndrome;
- increased mobility of the joint;
- restoration of homeostasis in the cartilage of the joint;
- stimulation of the synthesis of its own hyaluronic acid.
Composition, form of release
The main active ingredient of the drug is sodium hyaluronate. It is a biological analogue of natural hyaluronic acid, which is produced in the human body. 
This preparation is prepared for release as a 1% sterile clear solution intended for intraarticular administration. The medicine is placed in a glass syringe, which is packed in a blister, and then into a cardboard box. The package contains one syringe, designed for a single injection. The syringe has a special protective rubber cap and threads for tight connection with the injection needle clutch. Such a design eliminates the leakage of the drug during administration.
A 2 ml solution consisting of 20 mg of active substance, which is dissolved in phosphate buffer, is placed in the syringe. The outer side of the syringe is treated with ethylene oxide, so it is sterile and fully ready for use.
During the clinical trial, the drug was found to have no toxic, mutagenic and allergic properties.
Properties of the preparation
"Fermatron", reviews about which application is already quite numerous, leaves no doubt about its useful properties. It has long been known how important is hyaluronate for the normal operation of joints. It is proved that it penetrates into the joint cavity, thereby stabilizing the structure of proteoglycans. And this, in turn, gives the cartilage elasticity and strength.
In addition, the drug reduces the activity of enzymes that are involved in processes leading to the destruction of cartilage tissue. The medicine also exhibits the properties of an antioxidant and reliably protects the joint tissues from the harmful effects of free radicals. It is also important to stimulate the synthesis of its own hyaluronic acid, this has an unquestionable positive effect on the musculoskeletal system.
Physically, "Fermatron" is a substitute for articular fluid with hyaluronic sodium salt in the composition. Since the synovial, that is, the joint fluid, serves as a lubricant for the moving parts of the joint, a decrease in its volume in the case of various diseases leads to the defeat of this organ. In these cases, "Fermatron"( reviews of patients confirm this) restores the lack of fluid joint, thereby removing inflammation, increased friction and pain, and improves joint mobility and restores metabolism.
Action of the preparation
The effect of the drug "Fermatron" is due to its physico-chemical properties and biocompatibility, since the drug contains an equivalent to human hyaluronan. This substance is a polysaccharide having a high molecular weight. It consists of repeated disaccharide residues of glucuronic acid and N-acetylglucosamine, which are the components of the joint synovial fluid. The substance is synthesized by fermentation of Streptococcus equi and then thoroughly cleaned. Hyaluronan functions as a kind of shock absorber under the action of direct loads on the joint and lubrication under lateral loads. It also stimulates synovial cells, carrying out the function of a filter that does not pass molecules and cells that damage the cartilage.
A clinically valid result is given by "Fermatron"( reviews of patients also confirm this) after the fourth or fifth injection. The effect of treatment persists to six months, sometimes more, after the last injection.
When the drug
is used The use of the drug is shown mainly in the treatment of arthritis and arthrosis. In addition, "Fermatron" is able to quickly stop pain, as well as to remove inflammation caused by trauma or degenerative processes inside the joint. It is possible to use this medication and with tight mobility of the knee and other joints.
The drug is also used in all stages of osteoarthritis, as well as after arthroscopic interventions.
Today, doctors often prescribe patients a drug "Fermatron Plus."The patients' testimonies indicate that it actually helps to eliminate and alleviate the main manifestations of certain diseases.
"Fermatron": instructions for use, reviews
The first thing to remember - this drug can not be used alone. Dosage, schedules of injection and their number can be assigned individually only by a doctor after preliminary examination and determining the degree of joint changes. And the procedure must necessarily be performed by a specialist in view of the fact that it is associated with direct insertion into the joint. Doing injections can be done on an outpatient basis and at home by inviting a qualified health worker for this. 
In a moderate course of the disease, as a rule, up to four to five injections are administered, which are administered once a week. The injection is made with a sterile needle of the appropriate size after preliminary treatment of the skin with an antiseptic. The medicine must have room temperature, the remnants of it in the future are not used and are disposed of together with a syringe and a needle.
If there is exudate inside the joint before injection, it must be removed. The effect of the drug comes after the first injection.
Contraindications to the use of
Do not use "Fermatron"( the doctors' reviews are unambiguous) if the following conditions are observed:
- violation of the integrity of soft tissues and skin in the joint region;
- stagnation of lymph or blood in the joint space;
- significant inflammation and infection of the joints;
- treatment of young patients;
- acute synovitis;
- elevated immunological response of the body to any of the components of the medication;
- pregnancy and feeding - studies on the effect of the drug in these cases have not been conducted. Perhaps appointment after a doctor's consultation.
Side effects of
After the introduction of the medication "Fermatron" into the joint cavity( reviews of patients on this topic are almost not found), it can develop a feeling of warmth, redness, a swelling. Also, post-injection edema and passing pain, and rarely inflammatory processes, can be disturbing. In such cases, a ten-minute imposition of a cooling compress on the joint is allowed.
Most often such phenomena are short-lived and pass independently, without additional therapeutical procedures. Allergy to the drug occurs extremely rarely.
"Fermatron": reviews and how it is transferred
The use of drugs with hyaluronic acid for intra-articular treatment in modern medicine often avoids serious complications and more complex kinds of treatment. 
Sometimes, after the first couple of injections, there is restlessness, discomfort and a feeling of stiffness, but this quickly passes. And after the completion of the course of treatment, not only the unpleasant manifestations disappear, but also the symptoms of the disease. So, not very pleasant injection feelings pay off with more than a single action of the drug.
The price of the drug "Fermatron", patients' reviews confirm this, is relatively high( about 5 thousand for one injection, plus or minus 200 rubles, depending on the pharmacy network and the city), but the effectiveness of the injections is worth it.
Almost all who used this medication for treatment, note a quick return to active life, almost instantaneous disappearance of pain. Often the use of this drug gives a delay or completely postpones surgery for endoprosthetics.
Precautions and special instructions
Treatment can be carried out both in a medical hospital and outpatient, in compliance with sanitary requirements.
During the treatment with the drug "Fermatron", reviews of patients and doctors in this converge, the patient can continue to engage in daily activities, protecting the site of the injection, that is, the problematic joint, from static and dynamic loads. 
When prescribing a medicine, it is necessary to take into account the potential risk and immunological reactions associated with the introduction of biological material into the human body.
The use of the drug with damaged packaging is not recommended.
No data are available on whether Fermatron is compatible with other drugs intended for intra-articular injection, therefore, their combined use is not recommended.
"Fermatron C" is not used( instructions for use indicate this) in the presence of autoimmune atologies, for example, Bekhterev's disease.
Also not recommended for joint use of this drug and pain medication.
Analogues and storage conditions for
Joints can also be treated with structural analogues of the "Fermatron" preparation according to the active ingredient. Here is their list:
- "Ostenil"( Ostenil);
- "Hyalur";
- Ostenil plus( Ostenil plus);
- "Suplazin"( Suplasyn);
- "Fermatron S"( Fermathron S);
- "Durolane"( Durolane);
- "Ostenil mini" or "Ministhenil"( Ostenil mini, Miniostenil);
- "Synocrom Forte"( Synocrom Forte);
- "Fermatron plus"( Fermathron Plus);
- "Synocrom"( Synocrom);
- "RusVisk"( RusVisc);
- "Synvisc"( Synvisc).
Store the drug in a dry place, protected from sunlight, and out of the reach of children. Storage temperature should not exceed 25 ° C, the medicine should not be frozen.
Shelf life is three years, after the specified time, the use of the drug is excluded. The medicine is subject to a doctor's prescription.