The drug "Daraprim": instructions for use, reviews, composition, analogues and reviews
Malaria is a group of infectious vector-borne diseases that are transmitted to humans after bites of Anopheles mosquitoes. For such a pathological condition is characterized by fever, chills, splenomegaly, hepatomegaly and anemia.
If untimely and incorrect treatment of malaria occurs, death( in most cases).
The drug "Daraprim" is most often used to treat this disease. Instructions for use, reviews, prices and analogues of this medication will be provided below.
Composition, form, packaging and description of the preparation
The medicinal preparation "Daraprim", the instruction of which is contained in a cardboard box, goes on sale in the form of tablets of matte white color. The active substance of the agent under consideration is pyrimethamine.
You can buy this medicine in contour cells, which are placed in cardboard packs.
Features of the drug
What is the drug "Daraprim"?Instructions for use indicate that this antiprotozoal drug. It has antitoxoplasmoid and antimalarial action, and also promotes the blocking of folate reductase, which converts folic acid to folinic acid.
This medication is effective against plasmodia and causative agent of toxoplasmosis. It also has schizontocidal action.
In the human body, the drug in question does not affect the forms( sex) of the malarial plasmodium, since it is devoid of gamontocidal activity. However, this remedy is able to suppress the process of fertilization with a gamont in the body of the transporter( that is, it has a gamontostatic effect).
Indications for admission
Drug "Daraprim", the instruction of which will be presented below, is intended for the treatment and prevention of malaria. It is also prescribed for toxoplasmosis( congenital and acquired) and uveitis( toxoplasmosis or unknown origin).
Contraindications of tablets
Under what conditions can not prescribe drug "Daraprim"?The instruction states that this remedy is contraindicated in hypersensitivity and megaloblastic B12-deficient anemia, which is associated with a lack of folic acid.
With special care, this drug is prescribed for folate-deficient conditions and hepatic or renal insufficiency.
Medication "Daraprim": instruction for use
Analogs of this medication will be listed below.
Take these tablets only inside. Their dosage depends on the indications.
For the prevention of malaria, the drug is prescribed 1 tablet once a day. Children aged 5-10 years are recommended to take a medication in a half dose.
Prevention should begin shortly before or immediately after arriving in an area where there is a high likelihood of contracting malaria. In this case, the use of the drug at the indicated dosage should be continued for the following month.
How for the treatment of malaria to take the drug "Daraprim"?The instruction informs that the therapy of such a disease is carried out in a complex manner. The medication is combined with "Sulfadoxine" or "Sulfaleno".It is prescribed in the amount of 3 tablets per 1 reception. Children aged 9-14 years are given 2 tablets of pyrimetrine, and 4-8 years - one.
For the treatment of toxoplasmosis children over 6 years and adults are recommended to take 2 tablets of "Daraprima" per day, and children 2-6 years - one.
The duration of treatment with this drug is 3-6 weeks. If necessary, the course can be repeated.
Taking an antimalarial drug can cause many different side reactions. We will upset the most frequently manifested:
- spastic abdominal pain, headache, dryness in the throat or mouth, weakness, nausea;
- dizziness, vomiting, dermatitis, diarrhea( at the beginning of treatment), rash, depression;
- skin pigmentation change, fever, anemia, leukopenia;
- circulatory collapse, thrombocytopenia, ulceration in the oral cavity, phenylalanine, insomnia.
"Warfarin" and "Quinidine" increase the toxicity and effectiveness of the drug.
The risk of toxic damage to the liver increases significantly when the combination of "Daraprima" and "Lorazepam".Myelosuppression, which is caused by cytostatics( including Methotrexate), also increases.
In children with leukemia and CNS lesions, after the introduction of "Pyrimethamine" and "Methotrexate", the likelihood of seizures increases.
In people who suffer from acute myeloid leukemia, the reception of "Cytosine-arabinoside", "Aurorubicin" and pyrimethamine can provoke aplasia of the bone marrow.
Specific recommendations for the taking of the antimalarial drug
The drug in question is administered with caution to people with renal or hepatic insufficiency, as well as congenital deficiency of folic acid or due to malnutrition.
In the treatment of toxoplasmosis in order to reduce the risk of suppression of the bone marrow, it is necessary to additionally administer calcium folate or folic acid.
The patient's blood must be analyzed every week during the entire treatment period.
Analogues and cost
The price of the funds in question is about 7-8 thousand rubles. There are no structural analogues to this preparation. However, some experts say that such drugs as "Milife", "Zinerit"( powder), "Plakvenil" and "Lariam" possess similar properties.
Now you know the pharmacological properties of the drug "Daraprim."The instruction, the price of this tool were also presented in this article.
Find consumer reviews about this antimalarial drug is quite difficult. After all, as is known, about 85-90% of cases of infection with this disease fall on the regions of Africa. As a rule, children under the age of five are infected with it.
Specialists report that after using this drug, the death rate from malaria has significantly decreased. However, not all people have the opportunity to use this remedy for infection.