"Erexel": reviews of men, instruction manual, description, analogies
Does the drug such as "Erexel" work? Comments of men on the effectiveness of the funds in question will be considered at the end of the article. Also you will learn about what it is possible to replace said medication, in what form it is produced and what pharmacodynamic properties it possesses. 
Composition, description of the medicine and the manufactured form
"Erexel" - tablets of blue and oval form, coated with film( film).Their main active element is sildenafil citrate. Also, the composition of said medicament includes the following auxiliary constituents: microcrystalline cellulose, croscarmellose sodium, calcium hydrogen phosphate and Mg stearate.
As for the blue shell, it consists of blue Opadry II 85F20464( ie polyvinyl alcohol, macrogol, titanium dioxide, talc, indigo carmine aluminum lacquer).
In sale, the drug "Erexel"( reviews of men are more positive) comes in blisters, which are packed in packs of cardboard.
Principle of the drug
Violation of erectile function is a problem for many modern men. Therefore, pharmaceutical companies are developing more and more new drugs designed to treat this condition. One of them is the "Erexel".Reviews of men report that this medicine is good and quickly restores broken erectile work, and also provides a response to sexual arousal.
The effectiveness of this medication is due to its composition. Sildenafil is the active ingredient of this medication. It is a selective and potent inhibitor of the specific cGMP PDE5, which is responsible for the disintegration of cGMP in the cavernous body.
This component does not have a direct relaxing effect on the cavernous body, but it significantly enhances the relaxing effect of NO on this tissue. 
During sexual stimulation, local release of nitric oxide under the influence of sildenafil promotes oppression of PDE5, as well as an increase in cGMP content in the cavernous body. As a result, it increases blood flow and relaxation of smooth muscles.
Other features of the drug
What is noticeable tablets "Erexel" for men? The active ingredient of this medication often causes a transient impairment in the discrimination of colors such as blue and green. Experts associate this effect with the depression of PDE6, which takes a direct part in the process of transmitting light in the visual organs.
Kinetic properties of the drug
What are the kinetic features of the drug "Erexel", the analogues of which are indicated below? According to the instructions, after taking the medication inside, the active ingredient is absorbed very quickly. Absolute bioavailability of this drug is about 41%.
When taking sildenafil together with fatty foods, its absorption rate is significantly reduced. The above substance, as well as its main metabolite, bind 96% to plasma proteins.
Sildenafil is metabolized under the influence of microsomal isoenzymes of the liver. Its half-life is about four hours. 
Indications for prescribing
Drugs for potency are very popular among those who suffer from erectile dysfunction."Erexel" is designed to treat a disease that is characterized by the inability to achieve, as well as maintaining the penile erection sufficient for satisfactory sexual contact.
Thus, it can be safely noted that sildenafil shows high efficiency only with sexual stimulation.
Prohibitions on the use of
When should drugs not be used for potency? Tablets "Erexel" are contraindicated in the use of:
- simultaneous use of other drugs intended for the treatment of erectile dysfunction( efficacy and safety of sildenafil in such combinations have not been studied);
- constant or periodic application of donators NO, organic nitrates or nitrites in any form( since sildenafil enhances the hypotensive effect of nitrates);
- at a minor age;
- concurrent admission with ritonavir;
- high sensitivity of the patient to sildenafil or other component of the drug.
It should also be noted that the said remedy is not allowed to be assigned to females. 
Cautious use of
With caution, tablets "Erexel" should be used for heart failure, anatomical deformation of the genitals, diseases that predispose to the development of priapism, the tendency to bleeding, unstable angina, exacerbation of gastric ulcer, stroke, hereditary retinitis pigmentosa, myocardial infarction, arrhythmia, life threatening, hypotension, arterial hypertension, ischemic neuropathy of the optic nerve.
Tablets "Erexel": instructions for use
The drug should be taken only inside. The recommended dosage of this drug for most adults is 50 mg 60 minutes before sexual activity. Taking into account the tolerability and effectiveness of the drug, its dose can be increased to 100 mg or reduced to 25 mg.
The maximum daily dosage of this medication is 100 mg, and the maximum recommended frequency of use is 1 time per day.
In elderly people, correction of the dose of Erexel is not required.
If there is a moderate-to-moderate renal failure, dosage adjustment is also not required. As for severe renal failure, in this case, the dose of sildenafil is reduced to 25 mg.
In view of the fact that excretion of the drug in question is disturbed in people with liver damage, its amount should be reduced to 25 mg.
When taken concomitantly with ritonavir, the maximum single dose of sildenafil should not be more than 25 mg, and the frequency of its application is 1 every 2 days.
In parallel application of the drug with cytochrome CYP3A4 isoenzyme inhibitors, its recommended initial dose is 25 mg.
In order to minimize the risk of postural hypotension in people who take alpha-blockers, the use of the drug in question should be started only after reaching the stabilization of hemodynamics. Also in this case, it should consider the desirability of reducing the initial dosage of sildenafil. 
Side effects
What negative reactions can a drug "Erexel", the price of which is listed below, cause? In the attached instructions, the following effects are indicated:
- nasal congestion, headache, arthralgia, hot flashes, sinusitis, dizziness, rhinitis, insomnia;
- pharyngitis, dyspepsia, myalgia, vision change, asthenia, respiratory failure, diarrhea;
- increased muscle tone, abdominal pain, conjunctivitis, nausea, respiratory tract infections;
- urinary tract infection, flu-like syndrome, back pain, development of infectious diseases, priapism, symptoms of vasodilation, prostate gland function disorders, rash.
The main signs of an overdose of
With a single use of the drug in question at a dosage of 800 mg, the adverse reactions were comparable to those of a lower dose drug, but were more common.
The main signs of an overdose of this drug include the increased severity of side effects. If such occur symptomatic therapy. It should also be noted that hemodialysis does not accelerate the clearance of sildenafil. This is due to the fact that the active substance of "Erexel" is associated with plasma proteins and is not excreted by the kidneys.
Drug Interaction
How does sildenafil interact with other drugs? According to the instructions, the drug "Cimetidine" is able to increase the concentration of said substance in the plasma by approximately 56%.
A single application of "Erexel" together with erythromycin leads to an increase in the AUC of the former by 182%.
With parallel administration of saquinavir and sildenafil, the maximum concentration increases by 140%, and the AUC increases by 210%.In this case, the substance in question has no effect on the kinetics of saquinavir.
Such potent inhibitors of cytochrome CYP3A4, such as "Itraconazole" and "Ketoconazole", contribute to serious changes in the pharmacokinetics of sildenafil.
A single dose of antacid does not affect the bioavailability of the drug in question. In addition, sildenafil enhances the hypotensive effect of nitrates. In this regard, the use of this substance in combination with donators NO and nitrates is contraindicated.
In some sensitive people who receive alpha-adrenoblockers, the parallel use of sildenafil often leads to symptomatic hypotension.
The use of these tablets with antihypertensive drugs does not lead to the development of additional side effects.
What other interaction does the "Erexel" medication have? Alcohol is not allowed when taking this medicine. Otherwise, the effectiveness of this drug is significantly reduced.
Additional Information
Before the start of "Erexelas", a thorough CAS examination is necessary.
This drug should not be used in people for whom a sexual act is undesirable.
With caution, these tablets are prescribed to people with a tendency to bleeding.
Sildenafil has no influence on a man's ability to drive vehicles and manage other mechanisms.
Analogues and cost of
The analogues of the drug "Erexel" include such drugs as Viagra, Tornetis, Viassan-LF, Taxiere, Viatail, Sildenafil, Vigrande, Silafil, "Vizarsin", "Rijamp", "Vildegra", "Revazio", "Dynamics", "Olmax Strong", "Maxigra" and others.
How much does the medicine in question cost to treat potency disorders? The price of this medication in different pharmacies may vary. However, its average cost is approximately 715 rubles( for 4 tablets, 50 mg).
Preparation "Erexel": reviews of men
What do the representatives of the stronger sex say about such a drug as "Erexel"?Most reviews of the drug in question are extremely positive. Men claim that this is a highly effective medicine designed to quickly restore impaired erectile function, as well as providing a natural response to sexual arousal. It is enough to use only one pill of "Erexel", as there and then strong sex marks its effective action.
Regarding negative reports about this drug, most often they say that this medication can cause many side effects. In addition, some patients are unhappy with the high cost of this drug, given that there are only four stimulating pills in the cardboard bundle.