SIGNITEF( eye drops): instructions for use, description, composition and reviews

In what dosage is prescribed the medicine "Signtsef"( eye drops)?Instructions for use, price and indications of the drug will be presented in this article. Also in it you will find information about what the patients say about this tool, whether it has analogs, side effects and contraindications. signitis eye drops instructions for use

Composition, description and packaging

The preparation "SIGNITSEF"( eye drops), the instruction for which is enclosed in a cardboard package, contains an active substance such as levofloxacin hemihydrate. As additional components use sodium chloride, hydrochloric acid, benzalkonium chloride, hypromellose, sodium hydroxide and water.

For sale, the medicine in question is presented in the form of a transparent liquid of light yellow color in the bottles-droppers made of plastic.

Pharmacodynamics of the preparation

How does the medicine "Signtsef"( eye drops) work? The instruction for use states that the said preparation is an antimicrobial and antibacterial agent.

Its active substance inhibits topoisomerase IV and DNA gyrase, as well as inhibits DNA synthesis, prevents cross-linking and supercoiling of DNA.It should also be said that the drug in question can provoke morphological changes in the cytoplasm, membranes and cell walls of bacteria.

Eye drops have a detrimental effect on both gram-positive and gram-negative aerobes. In addition, they are active against Chlamydia trachomatis.

After application of the drug, its active component accumulates in the lacrimal film. At the same time, the concentration of the drug substance in the tear fluid quickly reaches high values ​​and lasts for six hours. signitis eye drops Instruction for use price


When should I use the medicine "SIGNITSEF"( drops)?Instructions for use, reviews of ophthalmologists say that the drug in question is often used with:

  • therapy for anterior segment infections and an adnexa, which was provoked by bacteria sensitive to levofloxacin;
  • the need for preventive measures after operations on the eyes;
  • is a local therapy for infectious eye diseases that have been provoked by bacteria susceptible to levofloxacin.

Contraindications to the use of eye drops

What contraindications should I know before using SIGNITEF( eye drops)?The instruction for use states that this medication should not be prescribed with:

  • lesions of tendons;
  • hypersensitivity to the elements of the drug;
  • previously treated with quinolones;
  • breast-feeding;
  • epilepsy;
  • pregnancy.

Also, do not use eye drops for infusions. With caution this drug is prescribed in childhood. signitecef drops instructions for use review

Preparation "SIGNITEF"( eye drops): instruction

The prices and analogs of the medication under consideration will be presented at the end of the article.

Instruction informs that this drug should be started to be applied within the first two days after the appearance of signs of the disease. The drug is instilled in the infected eyes in an amount of 1-2 drops at intervals of 120 minutes.

The maximum frequency of this medication is 8 times a day. In 2 days after the beginning of treatment the drug is started to be applied in the same dose, but already 4 times a day.

The duration of therapy directly depends on the characteristics and severity of the disease. Usually treatment lasts for 5 days.

Before applying drops to the patient, the head should be turned back, and then the lower eyelid should be pulled back. It should be dripped with a medicine, and then for a few minutes to close your eyes.

To prevent the drug from entering the lacrimal duct, the inner edge of the optic organ should be pressed with your finger and kept in this condition for 1-2 minutes. At the same time it is forbidden to blink.

As for the remnants of eye drops, they are removed with a clean cloth, but without contact with the eyes. signitis eye drops instructions prices and analogues

Adverse Reactions

Side effects on the background of the use of the drug in question are extremely rare. As a rule, such reactions are characterized by moderate or low severity and after some time pass independently.

So what are the undesirable effects of SIGNITSEF?The instructions for use( the description of the drops described above) indicate that this agent may provoke the appearance of the following ophthalmic disorders:

  • burning in the eyes, maturation of the eyelids, deterioration of visual acuity;
  • pain in the eyes, papillary conjunctival reaction, edema of the eyelids;
  • conjunctival follicles, pruritus, erythema eyelid, conjunctival infection;
  • chemosis, photophobia, dry eyes.

Sometimes, on the part of the immune system, anaphylactic and allergic reactions are observed in patients.

As for the central nervous system, dizziness, drowsiness, headaches, paresthesia, confusion, fear, weakness, movement disorders, anxiety, insomnia, depression, hallucinations and convulsions can occur on her part.

Rhinitis, thoracic and mediastinal disorders may also occur.

Cases of overdose

In case of accidental ingestion of eye drops, toxic effects on the body are excluded. This is due to the fact that the amount of levofloxacin in the preparation is too low.

If a local overdose occurs, the patient may experience increased adverse reactions. In this case, the drug should be discontinued and the eyes thoroughly rinsed with warm water. eye drops signitisce instructions price reviews

Drug Interaction

The drug "SIGNITSEF" reduces the effectiveness of agents that inhibit bowel motility, as well as aluminum-containing and magnesium-containing antacid drugs, sucralfate and iron salts. The interval between the use of these medicines should be two hours.

These droplets increase the half-life of "Cyclosporine".

Removal of levofloxacin is significantly slowed by the simultaneous use of drugs that inhibit tubular secretion, and "cimetidine."

Special recommendations

Eye drops "SIGNITSEF" are not recommended for use during the wearing of soft contact lenses due to the presence of preservative benzalkonium chloride in the preparation.

To prevent dirt from entering the vial, do not allow dropper contact with mucous eyes.

Price, similar preparations

The average cost of the funds in question is about 220 rubles.

With regard to similar drugs, they include the following: Oftakvix, Glevo, Lebel, Levobaks, Levogrin, Levolety, Levotor, Levofast, Loksof, Novoks"," Remedy "," Floksium. "signitis instructions for use description

Reviews of eye drops

Eye drops "SIGNITSEF"( instruction, price, reviews described in this article) are a very popular drug. Reviews about them are mostly positive.

Patients talk about the high effectiveness of the solution. He treats infectious diseases of the eye quite quickly, and is also great for prevention.

Among the negative responses are those in which patients complain about the high cost of medication and the inability to use it during breastfeeding and when carrying a child.