"Pyrogenal": reviews and analogues
How effective is Pyrogenal? Reviews about this tool are discussed at the very end of the article. In addition, your attention will be presented to the properties of this medication, its release form and methods of application. 
Form, description of the medicine, composition
The preparation in question is sold in the following forms:
- "Pyrogenal" - injections. Experts say that such a product is issued in the form of a colorless and transparent intramuscular solution in ampoules of one milliliter. Its main substance is lipopolysachard, which was isolated from the bacteria Salmonella typhi. Also in the composition of this drug liquid is a buffer phosphate-salt solution with a pH of 6.7-7.3.
- "Pyrogenal" - rectal suppositories. Reviews of pharmacists indicate that such suppositories have a yellowish white color, as well as a cylindrical shape, pointed at one end. The active component of this agent is bacterial-type lipopolysaccharide and such auxiliary elements as lanolin, purified water and cocoa butter.
Pharmacology of the medicinal preparation
What is the medicine "Pyrogenal"?Experts say that this is a nonspecific highly active immunomodulator that can induce a complex of complex physiological and immunological changes in the patient's body, and also activate fibrinolytic, hypothalamic-pituitary and reticuloendothelial systems.
This drug shows desensitizing, anti-inflammatory and adjuvant properties, and also increases the specific and general resistance of the human body and affects the centers of thermoregulation of the hypothalamus.
Features of the drug
What is remarkable about such a tool as "Pyrogenal"?The doctors' comments say that this medicine is capable of activating macrophages, enhancing phagocytosis, stimulating the production of interleukin-1, which causes proliferation of body cells, interleukin-2, necessary to support lymphocyte growth, induction of interferon( endogenous), tumor necrosis factor and active forms of O2.It should also be noted that the increase in activity of phagocytes accelerates the formation of antibodies and promotes the growth of antimicrobial resistance of the human body.
Thus, due to the activation of monocyte-macrophage series and cytokines secreted by them, the working activity of the humoral and cellular immune response is markedly increased.
The influence of the preparation "Pyrogenal" in the connective tissue inhibits the development of fibroblasts, as well as the formation of collagen fibers, which ultimately leads to the rejuvenation of the composition of cells and the slowdown of glial scarring.
It should also be noted that taking this medication can prevent the formation of new and resorption of previously formed dense scars and adhesions in the injury sites, as well as prevent vascular obliteration and stimulate epithelialization and tissue regeneration.
Properties of the drug
What characteristics are characteristic for a medicine such as Pyrogenal? The reviews indicate that this agent not only stimulates the activity of hyaluronidase and the kinin system, but also improves the fibrinolytic properties of blood, and also increases the active activity of lysosomal enzymes and the permeability of tissues, accelerates the penetration of medicinal elements into the lesion, eliminates the inflammatory process and restorescirculation. 
It should also be said that the use of "Pyrogenal" helps to activate the pituitary system, increase the concentration of hormones in the blood, anti-inflammatory and analgesic effect.
Indications for use
What is the purpose of the medication "Pyrogenal"?The application( reviews of this agent are presented below) of the drug in question is indicated for non-specific therapy:
- for traumatic injuries of peripheral and central HC, cerebral arachnoiditis and spinal hernias;
- in surgery for adhesions, after-burn keloids and contractures, injuries, vascular diseases, and to prevent vasodilatation;
- for infertility and inflammation of the uterine appendages;
- for chronic liver disease;
- for adhesions of the abdominal cavity;
- with the torpid current form of tuberculosis at the stage of resorption;
- for severe burns of the optic organs, iridocyclitis, uveitis, corneal opacity, herpesvirus infection of the eyes, neuralgia of the auditory and optic nerve, conjunctivitis and viral keratitis;
- with ureteral and urethral strictures, as well as chronic urethritis and prostatitis;
- for venereal diseases, psoriasis and other ailments of chronic skin;
- with resistance of microorganisms to antibiotic and chemotherapy.
It should also be noted that as a pyrogenic drug, the drug in question is actively used for indications for pyrotherapy, including dermatovenereology, narcology and psychiatry.
Prohibitions on the use of
When should I not use Pyrogenal? Reviews speak of the following contraindications to the use of the medicine:
- chronic illnesses in the stage of decompensation and exacerbation, except for those that are indications for the prescription of the medication;
- blood disease;
- febrile illness( acute);
- lactation period and pregnancy time.
Patients suffering from kidney disease, chronic cardiovascular diseases and diabetes, Pirogenal therapy should be administered only under the supervision of a doctor.
In the presence of febrile seizures and convulsive readiness, the drug in question is either not used, or is administered together with anticonvulsant therapy.
The preparation "Pyrogenal": instruction for the use of
The doctors' comments inform that intramuscular injections of this medication should be performed one day after one injection per day.
To prepare a medicinal solution, the contents of the ampoule must be mixed with sodium chloride.
The course of treatment with this drug starts with a dosage of 2.5 mgk, after which it is gradually increased( every day) by 5 mgk. The maximum permissible single dose of "Pyrogenal" is 100 mgk.
The course of treatment with the drug in question is usually limited to 15-30 injections. Repeated injections can be carried out only after two months.
How should I use the drug in the form of a candle? According to the instructions, rectal suppositories use one piece per day( 50 mg).The greatest dosage of this drug per day is 200 mgk.
Patients using this form of medicine should follow the following treatment regimen: rectal suppositories are administered three times a day at a dosage of 50, 150, 100 or 120 mgk.
Usually one course of therapy consumes about twelve suppositories. Most often such candles are used for the purpose of immunorehabilitation and for immunoprophylactic treatment in the process of recovery of the patient after acute bacterial and viral diseases in a dose of 100 or 50 mgk. As a rule, the course of such therapy is limited to 10 suppositories.
Combining injections and candles "Pyrogenal" is not prohibited.
Negative effects of
What side effects does the "Pyrogenal" medication cause? Reviews of men and women say that with the use of suppositories they often increase body temperature to 37.6-37.8 degrees, and also show primary influenza symptoms such as chills, fatigue, fever, nausea, headaches, arthralgia and myalgia. 
As for the solution for injection, when it is administered in patients the same adverse reactions are observed, there are pains in the lower back.
The interaction of
"Pyrogenal" can be combined with the drugs used to treat the above indications. In this case, it should be remembered that as part of complex therapy, this agent can enhance the action of chemotherapeutic drugs.
Similar tools
There are no analogues of the preparation "Pyrogenal" for the main active substance. As for similar drugs for pharmacological action, they include the following: Prodiogisan and Transfer-Factor. By the way, the last drug is considered the most effective and qualitative.
Reviews about the drug
What do experts say about the preparation "Pyrogenal"?Reviews of gynecologists and other doctors are very diverse. According to their statements, the provocation with the medicine "Pyrogenal" contributes to a more rapid formulation of the correct diagnosis, as well as the timely initiation of adequate treatment.
As for patients, most of them refer to this remedy exclusively from the negative side, paying special attention to the pronounced painfulness of injections.
It should also be noted that many are simply not prepared for side effects such as fever and malaise that occur at the beginning of therapy. Although the therapeutic effect of this drug in patients' reviews is not criticized.