Cromoglycic acid. Description, indications, contraindications

What is cromoglicic acid? You will learn about this from the materials of the article. Also we will tell you about what medicines contain the mentioned substance and what it is. cromoglycic acid

Release forms, description

Cromoglycic acid is available as an aerosol for inhalation, nasal spray, eye drops and nasal spray. Also, this agent can be purchased in the form of a clear solution and capsules with powder, intended for inhalation.

Principle of action of the drug

Cromoglycic acid, the price of which is indicated below, stabilizes the membranes of mast cells, as well as their granules. This is due to the blockade of entry into the cells of calcium.

It should also be noted that this agent inhibits the release of allergy mediators such as leukotrienes, histamine, PG2 and others, from various cells that are in the mucosa of the bronchi and in the lumen of the bronchial tree. In addition, this substance helps suppress the migration of monocytes and neutrophils.


Cromoglycic acid exhibits the following properties:

  • Very effective for the prevention of allergy of immediate type in young people who have not yet had irreversible chronic changes in the lungs. It should be noted that this substance does not eliminate the already developed bronchospasm.
  • Has a membrane-stabilizing effect. In the lungs, the inhibition of the mediator response helps prevent the development of early and late stage asthmatic reactions( including in response to immune and other stimuli).
  • The stable effect of using the medication is achieved after 2-4 weeks. The effect of the drug after a single administration is observed for 5 hours.
  • A noticeable result of treatment for allergic diseases of the visual organs occurs after several days or weeks.

sodium cromoglycate

  • Prolonged use of the drug reduces the frequency of asthma attacks bronchial, and also significantly facilitates their course, reduces the need for admission GCS and bronchodilator funds.

Kinetics of

Cromoglycic acid is absorbed from the respiratory tract in an amount of 10%, and after inhalation of the drug powder and solution, 5-15% and 8%, respectively.

Absorption from the mucous membrane of the respiratory system decreases with an increase in the amount of secretion. The maximum concentration of this substance is reached after ¼ hours.

This drug is not metabolized. Its half-life is 45-90 minutes. It is excreted through the intestines and kidneys in approximately equal proportions, and also through the lungs.

With intranasal injection into the bloodstream, about 7% of the drug is received. With plasma proteins, it binds to 65%.In this case, the agent is not metabolized and is excreted with bile and kidneys unchanged for an hour and a half. Part of the active substance is swallowed and absorbed without excretion by the gastrointestinal tract.


Anti-allergic eye drops are prescribed for allergic conjunctivitis, allergic keratitis, keratoconjunctivitis, dry eye syndrome, overexertion, eye fatigue, irritation of the visual mucosa due to allergic reactions. cromoglycic acid

It should also be noted that this drug is used to prevent bronchial asthma, bronchospasm and chronic bronchitis with bronchial obstructive syndrome.

The drug in the form of an intranasal agent is recommended for use in hay fever and allergic rhinitis.


The drug in question is not prescribed with:

  • hypersensitivity;
  • pregnancy( first trimester for inhalation);
  • in childhood( up to two years - in the form of capsules with powder and solution for inhalation, up to 5 years - in the form of an aerosol for inhalation and intranasal application);
  • Breastfeeding( for intranasal administration).

Cromoglycic Acid: Instruction

Inhalation of the contents of the capsules for inhalations should be carried out with the help of a spinhaler 4 times a day at intervals of 3-6 hours( 20 mg each).

Dosed inhalation aerosol is administered at 1 dose( 1 mg) four times a day.

Solution for inhalation is used with an inhaler( 20 mg) four times a day. Before use, the balloon is shaken carefully and kept in an upright position. eye drops antiallergic

Drops in the nose appoint adults in each nasal passage of 3-4 drops in 4-6 hours, and children from 6 years - every 6 hours for 1-2 drops. After the appearance of the therapeutic effect, the interval between the medications can be gradually increased.

Spray nasal is used for 1 dose in each turn of the nose 4-6 times a day. The course of treatment is 4 weeks. Cancellation of the drug should be done gradually over a period of one week.

Eye drops( for example, "Sodium Cromoglycate") use 1-2 drops in each visual organ four times a day at intervals of 4-6 hours. If necessary, the number of instillations is increased to 6-8 drops.

Side effects of

This agent can cause:

  • dizziness, nausea, nosebleeds;
  • irritation and dryness in the pharynx, headache, dry mouth, delayed urination;
  • irritation of mucous respiratory organs, nasal congestion, coughing, burning in the eyes, impaired renal function, increased secretion of nasal secretions;
  • skin rash, conjunctival edema, dry eyes, unpleasant gustatory sensations, foreign body sensation, barley, lacrimation;
  • anaphylaxis( including difficulty swallowing, itching of the skin, pronounced stridorous, urticaria, swelling of the lips, face and eyelids, lowering blood pressure, shortness of breath).

Synonyms and the price of the drug

Under what trade name is the cromoglycium acid sold? These are Ditek, Sodium Cromoglycate, Iphiral, Intal, Cromogexal, Cromogen Light Breath, Nalcrom, Cromogen, Cromoglin, Cromosol, Cromolyn, Cropoz"," Lecrolin "," Kuzikrom "," Stadaglycin "," High-Krom ".cromoglycic acid price

The price of this product may vary, depending on the manufacturer, the form of the medicine and the pharmacy network. However, the average cost of cromoglycic acid is 100-250 rubles.