Hypothalamic syndrome of the pubertal period: causes, symptoms and features of treatment

Unfortunately, the process of growing up does not always pass unnoticed. In some cases, due to hormonal leaps, many unpleasant symptoms and diseases may appear. One of them is the hypothalamic syndrome of the pubertal period( GSPP).

hypothalamic syndrome of pubertal period

Let's consider in more detail the basic information about the disease.

What is the hypothalamic syndrome of puberty?

It is a set of various symptoms, the appearance of which was provoked by the disturbances of hormone-exchange functions of the body as a result of the defeat of the hypothalamus and adrenal glands.

hypothalamic syndrome of pubertal period in girls

In this case, the hypothalamic syndrome of the pubertal period in girls is more often about 10 times than in boys.

In the medical literature, there are many other names for this disease: pubertal youthful basilism, pubertal basophilism, diencephalic pubertal period syndrome, pubertal youth adolescence, pubertal juvenile dyspeptoitarism, puberty basophilism syndrome.

Symptomatics and Diagnosis of

Disease Hypothalamic pubertal syndrome can be accompanied by a variety of specific symptoms. In this case, they are observed in one or simultaneously in several systems of the body.

hypothalamic syndrome pubertal period reviews

So, what are the signs that characterize the hypothalamic pubertal syndrome?

  1. From the side of metabolic processes. Patients are concerned about persistent thirst and a marked increase in appetite. During the examination, the expert notes a uniform deposition of fat in the shoulder, neck, hip, waist. In this case, the face becomes rounded and has a pathological blush.
  2. From the nervous system and the psyche. Patients complain of frequent dizziness, headaches, memory and sleep impairment, fast fatigue, depression, irritability, tearfulness. Objective study determines the different size of the pupils, as well as the deviation of the tongue away from the horizontal line, the asymmetry of reflexes, nasolabial folds and eye cracks, horizontal nystagmus.
  3. From the cardiovascular system and blood pressure. The disease is accompanied by a decrease. In 55-75 percent of cases, the pressure is asymmetric, labile, and there may be hypertension. In addition, it is possible to disrupt the rhythm of the second tone over the aorta, intracranial hypertension, increase the level of secretion in the blood of cortisol and aldosterone, angiopathy of the retina.
  4. On the part of the reproductive system. Failures can be observed in the form of disorders of the menstrual cycle, uterine bleeding. The doctor also conducts an objective study. Young people who have a hypothalamic syndrome of the pubertal period, look a little older than their age. At the same time, their sexual maturation occurs 1-2 years faster in comparison with their peers. In boys, the face acquires a female type, on it hair grows very bad even after a period of puberty. Possible development of gynecomastia. With all this, the size of the penis, scrotum and testicles fully correspond to the age and reach the final development by 15 years. As for girls, they have early formation of secondary sexual characteristics. Failures usually begin after some time( up to five years) after the start of the first menstrual cycle. They are manifested in the form of amenorrhea, uterine bleeding, very painful menstruation, hypomenstrual syndrome. Perhaps an increase in the ovaries.
  5. From the skin. The patient complains of the dryness of the skin and the violation of their integrity( stretch marks) in the abdomen, shoulders, hips, mammary glands, as well as excessive hair. During external examination, the doctor additionally observes the marble-cyanotic skin color and the presence of thickening of the stratum corneum in the shoulder, elbow, and also in the places of friction of clothing. In addition, the skin is cold to the touch, especially in the area of ​​the thighs and buttocks. There are striae of pink or red color and excessive amount of hair.

In addition to all this, there is an increase in the thyroid gland.

Causes of the appearance of the disease

To establish the exact cause of the onset of such a disease as the hypothalamic syndrome of puberty, scientists have so far failed. It is known only that several factors can contribute to this process, such as frequent infectious diseases in childhood or the presence of hereditary predisposition, the transferred birth trauma.

The pathogenesis of hormonal disease

The hypothalamic syndrome of the pubertal period can arise as a result of hereditary or non-hereditary factors.

In the first case, carriers of the idiosis genotype pass from generation to generation cells that are able to accumulate fat in them, changing the intestinal mucosa. Patients with this type of disease have a hyperliposintetic orientation of metabolic processes and increased absorption in the intestine, as well as enzyme defects.

In the second case, namely in the presence of non-hereditary factors, the nuclei of the hypothalamus or a disturbance in the interaction of the pituitary and gonadotropic hormones occur.


Based on different indicators, the hypothalamic syndrome of the pubertal period can be divided into species.

Depending on the nature of the course of the disease:

  • is stable;
  • is regressive;
  • progressive;
  • recurrent.

Depending on the clinical course:

  • with prevalence of neurocirculatory disorders;
  • with predominance of hirsutism;
  • with a predominance of obesity;
  • mixed.

Depending on the degree of severity:

  • heavy;
  • average;
  • is easy.

Depending on the form:

  • vegetative-visceral;
  • is neuro-trophic;
  • hypothalamic epilepsy;
  • vegetative-vascular;
  • neuromuscular;
  • is psychostenic, pseudo-neurasthenic;
  • violations of health and sleep;
  • thermoregulation disorders;
  • is neuroendocrine.

Who should I contact for help?

Who will help to eliminate such a disease as the hypothalamic syndrome of the pubertal period? The opinions of those who are confronted with this problem suggest that you need to contact several doctors at once. This is an endocrinologist, pediatrician, otolaryngologist, neuropathologist, and for girls additionally a gynecologist.

hypothalamic syndrome of pubertal period treatment

At the same time, the doctor's observation is mandatory, as the disease is characterized by a sharp deterioration in the state of stressful situations and in the absence of the necessary therapy.

Hypothalamic syndrome of the pubertal period: methods of treatment

Getting rid of the disease includes taking pharmaceuticals, adherence to a specially developed diet and exercise. In this case, for a successful recovery, it is important to clearly observe all the doctor's instructions. For more convenience, we will consider each of the types of therapy separately.


What drugs can help get rid of such a disease as the hypothalamic syndrome of the pubertal period? Treatment involves combining several types of therapy to eliminate all of its symptoms. hypothalamic syndrome of puberty

  1. Lipotropic preparations.
  2. Hypotensive therapy.
  3. Sedatives.
  4. Assertive therapy.
  5. Anorexic drugs( Orlistat, Meridia).
  6. Means for improving blood microcirculation( Cavinton, Stugeron, Cinnarizine).
  7. Preparations for improving the nutrition of cell structures( "Cerebrolysin", "Nootropil").
  8. Dehydration therapy( Furosemide, Magnesium Sulphate, Voroshpiron).

Diet and physical activity

First of all, it is important to review the diet. It is necessary to cancel numerous snacks, avoid overeating. It is important to remove from the teenager's menu all high-calorie foods, such as fatty meat, chocolate, ice cream, fast food and so on.

hypothalamic pubertal syndrome

Treatment provides compliance with diet number 8.It includes a decrease in the calorie content of foods due to carbohydrates and partially fat. It is also planned to introduce vitamins C, E, A into the ration and carry out unloading days.

Physical activity is aimed at reducing the amount of fat mass. It should include the conduct of morning exercises with the use of special exercises, outdoor games, sports, water procedures, evening walks.

Forecast for the future

As the statistics show, complete disposal of the disease occurs in 20-40% of cases.

hypothalamic syndrome pubertal period gspp

20% of patients have progression of the disease.

The rest have a hidden form of the disease, which is characterized by the occurrence of relapses. Those, in turn, can lead to the development of hypertension, diabetes, infertility, complications during childbirth, hypothalamic syndrome of the neuroendocrine form, secondary sclerokistoza ovaries.


The main ways to prevent the appearance of the hypothalamic syndrome of the pubertal period are adolescent adherence to a healthy lifestyle and adherence to the rules of rational nutrition. It is important to have physical activities and frequent walks in the fresh air.

In addition, it is mandatory to rehabilitate chronic foci of infection.

Stay healthy!