The drug "Arlet": instructions for use, contraindications, composition and reviews
Once the development of the simplest penicillin has become a panacea for a number of diseases of bacterial nature, from which people in most cases died. Since then, humanity has stepped into another millennium and has developed a number of medical antibacterial drugs as a broad spectrum of action, and sensitive to some specific strains of microorganisms. One of these means is "Arlet".The instruction for the use of this medication contains complete information about all its properties.
Composition of the antibacterial agent
The main components are amoxicillin trihydrate( in terms of amoxicillin possible volumes of 250, 500, 875 mg) and potassium clavulanate( volume - 125 mg in terms of clavulanic acid).The first component is referred to penicillin from a number of semi-synthetic, characterized by a wide field of antibacterial activity. The second major component of the drug is an irreversible inhibitor of beta-lactamases.
In addition, there are a number of auxiliary components included in the drug "Arlet".Instructions for use, the description of the drug is brought to the attention of consumers that the core contains low molecular weight povidone, pregelatinized starch, calcium stearate, microcrystalline cellulose and talc. And that is not all.
Antibiotic envelope forms hypromellose, propileglycol and polyethylene glycol 4000( or macrogol 4000), titanium dioxide. The weight of one tablet "Arlet"( instructions for use contains this information) is 600, 1100 or 1600 mg.
As mentioned earlier, "Arlet" is a complex of amoxicillin and clavulanic acid. The latter forms a stable inactivated complex with beta-lactamases( bacterial enzymes, the main functions of which are to counteract beta-lactam antibiotics, the most widely used for antimicrobial chemotherapy - cephalosporin, penicillin, etc.).Beta-lactamases are responsible for creating a persistent confrontation with the above-mentioned medical devices.
Clavulanic acid itself, whose structure is similar to that of beta-lactam drugs, is characterized by sufficiently weak own antibacterial abilities. Nevertheless, the presence of acid in the drug "Arlet" resists destruction of amoxicillin and increases the range of its antibacterial capabilities, including bacteria and microorganisms, which under standard conditions are resistant to the influence of amoxicillin, other drugs from the groups of penicillins and cephalosporins.
Antibiotic "Arlet" instructions for use regulate as a drug with a wide range of effects. It shows activity against susceptible to amoxicillin strains( not excluding those that synthesize beta-lactamases).These include a number of gram-positive and gram-negative aerobes and anaerobes.
Indications for use of the drug "Arlet"
The area of influence of the antibacterial agent is quite extensive, it is effective for a number of infections of different etymologies."Arlet" instructions for use allow to apply to eliminate problems with the upper respiratory tract and ENT organs. In particular, we are talking about acute and chronic forms of sinusitis and otitis media, tonsillitis, pharyngitis, abscesses in the retropharyngeal zone. The medicament has a positive effect in the treatment of diseases of the lower parts of the respiratory system, which include bronchitis( chronic and acute, accompanied by bacterial superinfection) and pneumonia.
However, this is not all areas where Arlet is used. Instructions for use, the description of the medicinal product is reported on its effectiveness in the treatment of diseases of the genitourinary system and pelvic organs. Such diseases include pyelonephritis, prostatitis and urethritis, endometritis and bacterial vaginitis, septic abortion, gonorrhea, etc.
Also positively affects the antibiotic in the treatment of skin and soft tissue infections of various origins( abscesses, phlegmon, rye, impetigo, woundedsurface and re-infected with dermatosis)."Arlet" can be used in the treatment of bone and connective tissues, with the treatment of bile ducts( cholecystitis, cholangitis), with odontogenic lesions, for the prevention of inflammatory processes in surgery, in postoperative periods.
Dosage and methods of application
For the drug "Arlet" the way of application and dose is set individually, and depends on the age, weight, condition of the kidneys and the severity of the infection. In order to minimize the likelihood of developing unwanted effects on the part of the digestive tract, take the pill before you start eating, wholly, do not chew and drink with water.
Patients older than 12 years of age or weighing more than 40 kg for light and moderate forms of infection take one tablet( 250 mg of the main component) three times a day or twice a day( 500 mg of amoxicillin).For severe lesions, take a dose equivalent to 500 mg of amoxicillin three times a day or 875 mg twice a day.
For patients from 6 to 12 years, the "Arlet" instructions for use recommends the use of 1 kg of body weight: amoxicillin 20-30 mg, clavulanic acid 5-7.5 mg. Usually, the dose for such patients is 1 tablet( 250 mg) twice or thrice daily or 1 tablet( 500 mg) twice daily. In severe cases, the dose can be doubled.
For patients with impaired renal function, the dose and frequency of administration are adjusted depending on the creatine clearance. Those who suffer from anuria, it is recommended to increase the intervals between doses to 48 hours or more. For patients on hemodialysis, the amount of medication is selected based on the maximum dose of amoxicillin.
People with abnormalities in the functioning of the liver are cautiously treated with Arlet. Instructions for use( annotation), reviews of medical experts recommend in a continuous regime to monitor the condition of this body.
For patients of advanced age, dose adjustment is not required.
Side effects of
A specific list of side effects contains an instruction manual for the Arlette antibiotic. Treatment( patients' reviews confirm) this agent can provoke a number of abnormalities on the part of the gastrointestinal tract in the form of lack of appetite, nausea, vomiting, diarrhea. Occasionally you can hear about violations of the liver function, even less often - about the development of cholestatic jaundice, hepatitis, pseudomembrane colitis.
The CNS response to the use of the drug "Arlet" can be headaches and dizziness, hyperactivity( in reversible form) and convulsive activity.
The hematopoiesis system can respond with the appearance of symptoms of leukopenia, hemolytic anemia, agranulocytosis. Prothrombin time may increase( in this case the process is reversible).Crystalluria and interstitial nephritis are the possible consequences of using the medication on the part of the urinary system.
The list of possible allergic manifestations for taking antibiotics "Arlet" is quite wide. The instruction, the description of the preparation inform the consumers about the possible development of pruritus, hives, erythematous rash. Occasionally one can hear about the appearance of symptoms of multiforme exudative erythema, angioedema, anaphylactic shock. There is information about single manifestations of side effects in the form of Stevens-Johnson syndrome and exfoliative dermatitis.
Contraindications for the use of "Arlet"
The list of reasons that limit the use of antibiotic, contains for the drug "Arlet" instructions for use. Contraindications restrict reception to those patients who suffer from individual hypersensitivity to the main and auxiliary components of the drug, to other beta-lactam antibacterial agents( penicillins, cephalosporins, etc.).Do not appoint "Arlet" and those who have a history of records of violations of liver function in the treatment of amoxicillin and clavulanic acid in the complex. Contraindicated medications for those who suffer from mononucleosis and lymphatic leukemia, as the likelihood of developing exanthema increases.
The basis for refusing treatment with this antibiotic is chronic renal failure and children under 6 years of age.
With regard to pregnant women, they can take Arlet only if the benefit to the mother is unquestionably greater than the estimated risk to the fetus. When lactating the main components of the drug in small amounts fall into the milk, so you should discuss with your doctor about the issue of refusal of breastfeeding.
Excess dose tolerance
Digestive tract disorders are the main group of symptoms, characteristic of an overdose of Arlet( tablets).Instructions for use, reviews of patients report vomiting, diarrhea, pain in the abdomen. In addition, possible conditions such as insomnia and dizziness, anxiety arousal. It is very rare to hear about convulsive seizures.
If symptoms of an overdose occur, the best solution for the patient is to be supervised by a specialist. Treatment in such situations is symptomatic.
If the intake of an unacceptably high dose occurred no more than 4 hours ago, it is necessary to rinse the stomach and take absorbent preparations( for example, activated charcoal) in order to minimize absorption. To remove from the body of amoxicillin and clavulanic acid, hemodialysis will be effective.
Interaction with other substances and medical preparations
With the parallel intake of "Arlet" and "Methotrexate", the toxicity of the latter will increase. Significantly decrease and decrease absorption in the treatment of antacids, glucosamine, aminoglycosides. Ascorbic acid, on the contrary, will increase absorption - this information contains an instruction on the use of the Arlette antibiotic.
The price of medication varies depending on the dosage and region, but they are available to a wide range of consumers. Therefore, it is necessary to consult with the attending physician, and not to combine the use of the antibiotic with other medications alone.
"Arlet" enhances the effect of indirect coagulants due to oppression of the intestinal microflora, decreased production of vitamin K and a decrease in the prothrombin index. With parallel administration with anticoagulant drugs, it is important to monitor blood coagulability indices continuously. The effectiveness of oral contraceptives is reduced.
NSAIDs, diuretics and other medications that suppress tubular secretion, increase the concentration of amoxicillin in the blood.
Tandem "Arlet" with "Allopurin" can cause the development of exanthema. Bactericidal antibiotics lead to synergism of action, and medicines with a bacteriostatic mechanism of influence - to antagonism.
For the reason that Arlet medicines( the instructions for use contain such information) with different doses of amoxicillin include, nevertheless, the same volume of clavulanic acid( 125 mg), it should be borne in mind that twotablets of 250 mg of amoxicillin are not at all equivalent to 1 tablet in 500 mg of this substance.
It should also be borne in mind that large amounts of amoxicillin can provoke a false positive response in determining urine glucose levels if such tools as Benedict's reagent or Felling solution are used for analysis. It is better to use enzymatic reactions with glucosidase in such cases.
When using antibiotic courses, it is necessary to constantly monitor the status of the functions of the organs of hematopoiesis, liver, kidneys."Arlet" in the recommended volumes does not affect the ability to drive vehicles and perform work that requires attention and increased speed of psychomotor reactions.
Price range and consumers' opinion about
The information on possible dosages of the main components in the composition of medication contains an instruction manual for Arlet( tablets).The price, as mentioned earlier, depends on the dosage and the region in which the drug is purchased. For example, tablets in a film shell at a dosage of 875 mg + 125 mg in Moscow can be purchased for an amount ranging from 270 rubles to 310( 14 pieces per package).In St. Petersburg, the same packaging will cost 278-282 rubles.
As for the patients' opinion about the drug, that is, both positive and negative responses to the drug. A large group of patients speaks of an excellent effect in the treatment of diseases of the ENT organs and upper respiratory tract. Medication effectively and quickly copes with sinusitis, and the period of remission is then quite long. Its effectiveness in the treatment of bacterial infections is also confirmed by patient reviews.
Negative reviews about the drug "Arlet" are most often due to the presence of hypersensitivity to the components of the drug in patients. In such cases, people often talk about abnormalities in the functioning of the digestive tract, such as dyspepsia, nausea and vomiting, diarrhea. There are practically no more serious deviations of information.
However, it should be said that if this antibacterial agent was prescribed by the attending physician and the optimal dose was chosen, various side deviations are extremely rare. If something like this happened, the doctor will pick up an analogue similar in effect and effectiveness, the benefit of the Russian pharmaceutical market is saturated with antibiotics with a wide range of effects.