The drug "Panangin Forte": instructions for use, reviews

Medication "Panangin Forte"( the instruction describes in detail the principle of the drug) improves myocardial metabolism. Take the pill with arrhythmia, restless sleep, arteriosclerosis of the coronary arteries, nervousness, numbness of the fingers and other symptoms that are caused by a deficiency of potassium and magnesium in the body. The elimination of these substances will help Panangin Forte.

Composition of the medicine and form of release

The drug is available in the form of tablets. Each contains 316 mg of potassium asparaginate, which in terms of potassium asparaginate hemihydrate is 332.6 mg and 280 mg of magnesium asparaginate, the amount of which in the form of magnesium aspartate tetrahydrate is 350 mg. These are the main active substances of the drug.

Additional ingredients in the tablets are:

• corn starch;
• talcum powder;
• magnesium stearate;
• potato starch;
• povidone KZO;
• silicon dioxide colloidal.

The shell of each pellet has in the composition talc, titanium dioxide, butyl methacrylate copolymer, macrogol.

Tablets are white in color and oval in shape. On one side there is the inscription "A83".The aluminum blister contains 15 tablets. A total of 60 Panangin Forte pills. Instructions for this medication are included.

The medicine is stored at a temperature of no more than 30 ° C in a place inaccessible to children. Shelf life from the date of manufacture is two years. The manufacturer of the drug is the pharmaceutical Hungarian company Gedeon Richter.

Pharmacology and pharmacokinetics of the medicine

Consists of the two main active ingredients Panangin Forte. The instruction notes that the drug can not be used without prescribing a doctor.

Magnesium and potassium cations play an important role in the preparation. They are involved in the work of many enzymes, they take a direct part in the creation of inter- and intracellular structures, macromolecules of special communication. Affect the muscle contractility. The contraction of the myocardium depends on the proportion of calcium, magnesium, potassium and sodium ions.

Endogenous asparaginate acts as a conductor of ions, as it is similar to human cells. There is a dissociation of its salts, after which ions in the composition of other compounds penetrate into the cell.

Aspartate of potassium and magnesium improve the activity of the myocardium, and their deficiency can cause severe degree of arterial hypertension, arrhythmia, coronary atherosclerosis, metabolic processes in the myocardium.

In the composition of "Panangina Forte" the active substances are twice as large as in the usual "Panangin".

Aspartates of potassium and magnesium are actively absorbed in the walls of the intestine, especially in the small intestine. They are excreted through the kidneys.

Medication "Panangin Forte": application of

The drug is used to compensate for the lack of potassium and magnesium together with other medicines in ischemic heart diseases, including acute myocardial infarction. It is often prescribed for chronic heart failure. Indications for use are violations of the heart rhythm, this also applies to arrhythmias, which is caused by an overdose with the use of cardiac glycosides.

Contraindications to the use of

All contraindications should be considered before using Panangin Forte tablets. The instructions for use contain detailed information about when you can not drink this drug.

As a rule, the medicine is not prescribed if there is excessive sensitivity to the active substances of the drug and its secondary components. It is forbidden to use the remedy for renal failure in acute or chronic form. Contraindication to use is hypermagnesia and hyperkalemia, impaired metabolism of amino acids, as well as Addison's disease. Do not use "Panangin Forte" in case of atrioventricular blockade of I-III degree, if there is shock, including cardiogenic, and with low arterial pressure. Do not prescribe the drug for myasthenia gravis in a severe stage of development, hemolysis and acidosis. Do not apply the drug to patients in a state of degradation, as well as to persons under 18 years of age, since the safety and efficacy of the drug in this case is not confirmed by clinical trials.

Women during pregnancy can use the medicine if the potential benefit to the mother's health is several times greater than the estimated risk to the fetus.

Potassium and magnesium asparaginate has the ability to penetrate into breast milk, so during treatment with the drug "Panangin Forte" breast-feeding should be interrupted.

Dosage and administration of

Must be taken only after consultation with the doctor tablets "Panangin Forte".Instruction for use notes that the drug is consumed orally. Pills swallow whole, without chewing and washing with water. The medicine needs to be drunk after eating. This is because the acidic stomach environment reduces its effectiveness.

Tablets are drunk one by one three times a day. The maximum daily allowance should not exceed three tablets. The duration of the course of admission is regulated by the doctor.

Side effects and overdose

All side effects should be taken into account when taking Panangin Forte medication. The instruction describes in detail the negative phenomena that can occur with prolonged and improper use of the medication.

At the use of a preparation at patients the gag reflex, a nausea, a burning sensation and a dyscomfort in an epigastrium zone can be observed. In some cases, there is atrioventricular blockade, as well as paradoxical symptoms, which is expressed in an increase in the number of extrasystoles. The intake of tablets can cause hyperkalemia and hypermagnesemia, which are manifested in paresthesia, diarrhea, nausea and vomiting. There is also reddening of the skin of the face, thirst appears, worries about low blood pressure. Sometimes hyporeflexia and respiratory depression are observed. Cramps may be disturbing.

Drug overdose is expressed in the manifestation of hyperkalaemia, which can be accompanied by excessive fatigue, heart rhythm disorder, paresthesia, myasthenia gravis, confusion.

Abuse of this medication can provoke hypermagnesemia. This decrease in neuromuscular excitability, gag reflex, lethargy, a significant lowering of blood pressure.

A sharp increase in the number of magnesium ions in the blood causes depression of the tendon reflexes, can provoke someone or paralysis of the whole body.

In all of the above cases, symptomatic treatment is performed. Usually this is the introduction of calcium chloride into the vein at a rate of 100 mg / min. If necessary, hemodialysis is performed.

Special instructions

During treatment, patients with hyperkalemia should be monitored continuously and blood potassium levels monitored.

With the simultaneous use of potassium-sparing diuretics such as triamterene or spironolactone, as well as co-administered treatment with beta-blockers, heparin, angiotensin converting enzyme inhibitors, cyclosporine, nonsteroidal drugs whose action is directed to the removal of the inflammatory process, the likelihood of hyperkalemia increases.

Complex potassium therapy in combination with glucocorticosteroids removes hypokalemia caused by the effects of the latter drugs.

Potassium reduces side effects from the use of cardiac glycosides. Increases the negative dromo- and butmotropic effects of antiarrhythmic medications.

Magnesium in the composition of the drug "Panangin Forte" reduces the effectiveness of the effects of tetracycline, neomycin, streptomycin, polymyxin B.

Anesthetics increase the oppressive properties of drugs with magnesium on the nervous system. Combined use with succinyl chloride, Atrakurium, suxamethonium and decamethonium increases musculoskeletal blockade. Calcitriol increases the amount of magnesium in the blood, and drugs with calcium reduce the result from the use of drugs with magnesium.

Medications that have astringent and enveloping properties, reduce the absorption of magnesium and potassium aspartate in the gastrointestinal environment. When they are used together in therapy, you need to observe a certain interval of intake( 3 hours) between the use of "Panangin Forte" with the above medicines.

Analogs

If necessary, you can always replace "Panangin Forte".The analogs are as follows:

• "Aspagin".
• to Asparks.
• Potassium and magnesium asparaginate.
• "Pamaton".
• "Panangin".

To avoid negative consequences, it is not necessary to replace one medicine with another yourself, as such decisions should only be taken by a doctor.

"Panangin Forte": difference from "Panangin"

The difference between "Panangin Forte" and the usual "Panangin" consists primarily in the concentration of active substances. In the first preparation, the content of potassium and magnesium is two times higher, so this medicine is taken one tablet 3 times a day, in contrast to "Panangin", which consumes 2 pills three times a day. Increased content of active ingredients in the drug "Panangin Forte" affected the price. This drug costs twice as much as "Panangin".The latter, in addition to the tablet form, is available as a solution for injections. This drug has more bioavailability than tablets.

Drug cost

The drug "Panangin Forte" can be purchased without a doctor's prescription in each pharmacy. Its value fluctuates around 300-350 rubles.

Reviews of patients and physicians

Warns of the need to observe the dosage when using the drug "Panangin Forte" instructions for use. Reviews say that the drug supports the work of the cardiovascular system, helps with heart rhythm disorders and removes cramps in the legs, puffiness of the extremities, normalizes the work in the walls of the heart ventricles, replenishes the deficit of potassium and magnesium, removes sharp changes in blood pressure. The results are already visible on the first and second day of use.

Among the shortcomings of the use of the drug, patients note the price and size of the tablet, because of which the drug can be difficult to swallow. There are no negative opinions about the medicine.

Says that you need to get acquainted with all the contraindications before taking the drug "Panangin Forte", instructions for use. Cardiology reviews of these tablets are only positive. Doctors say that the medicine helps to normalize the work of the heart and cope with pain in the chest, replenishes the lack of potassium and magnesium, can be used to prevent the deficiency of these components. Because of the increased content of active substances, this drug is more effective than the usual "Panangin".