"Clofranil": instructions for use, reviews, photos, analogies, side effects
Treatment of depressive processes is not without the use of antidepressants, which include the drug "Clofranil."The instruction recommends using it to eliminate various phobias, pain syndromes.
Description of the drug
Clomipramine hydrochloride is the active ingredient of the drug. Produced by the Indian company "San Pharmaceutical Industries" in the form of blue round tablets with a shell coating. 
The dosage of the drug is 0.025 grams of clomipramine hydrochloride.
Mechanism of exposure
The "Clofranil" medication refers to antidepressant agents with a tricyclic structure. With his participation, thymoanaleptic activity is carried out with psychostimulating, anxiolytic, alpha-adrenergic and soothing effect. The latter property is possible due to kinship with H1-histamine receptors.
Differs analgesic, histamine-blocking and antiserotonin effect. Eliminates the spontaneous excretion of urine at night, suppresses the desire to eat.
Has anticholinergic effects of peripheral and central character, caused by strong attachment to cholin-dependent receptor formations.
The drug "Clofranil" refers to antiarrhythmic drugs such as quinidine blocking sodium channels. Therapeutic doses of clomipramine inhibit conduction in the ventricles of the heart.
Antidepressant activity occurs due to an increase in norepinephrine level at the sites of neuronal and serotonin contact in the nervous system. These neurotransmitters accumulate due to the fact that membranes of presynaptic neurons are weakerly carried out by reverse capture.
Prolonged use causes a decrease in functional activity in the receptor formations of the serotonin type and beta-adrenoreceptors present in the brain, contributes to the normalization of adrenergic and serotonergic transfer, restores balance in systems that were upset by depressive manifestations. Tablets "Clofranil" help to cope with the inhibition of the psychomotor type, a depressed mood, an anxious feeling.
Analgesic activity manifests itself when the monoamine level changes in the parts of the central nervous system.
Anxiolytic effect occurs with reduced excitation of the nucleus in the brain stem of the brain, which is regulated by the function of beta and alpha2-adrenergic receptors, as well as by norepinephrine circulation.
Antidepressant activity is observed already 7 days after the start of treatment.
In clomipramine, compared with imipramine, the psychostimulatory effect is reduced, and when compared with amitriptyline, its sedative activity will be less pronounced.
For what are accepted
The "Clofranil" medication is recommended for use with depressive sensations of different development, characterized by certain symptoms.
The medication is prescribed for a depressive syndrome that accompanies schizophrenic manifestations, prolonged pain, bodily diseases and personality discrepancies. They are treated presenilny and senile type of processes, as well as their manifestations in childhood.
Drugs "Clofranil" instructions for use, the photo of which is presented below, indicates the use of a compulsively obsessive disease associated with phobias, with fears of panic, periodic painful sensations in oncology, migraine, rheumatic fever.
It helps with postherpetic nerve damage in the periphery, post-traumatic and peripheral neuropathy, narcolepsy, catalepsy. The drug is taken to prevent headaches and migraine attacks.
How to use
In the form of tablets, the "Clofranil" remedy is recommended for use when eating or after a meal in order to reduce irritation to the mucous membranes of the gastric wall.
For therapy use a small dosing, these rules apply to people in the elderly and adolescence.
Depression, obsessive compulsive disorder and various phobias are treated with a dosage of 0.025 g for 3 doses per day. In the first week the daily dose increases, for a day you can take from 0.100 to 0.150 g. If necessary, apply even larger doses. When there is an improvement, go to maintenance therapy, which ranges from 0.050 to 0.100 grams of medication.
Narcolepsy with attacks of catalepsy is eliminated with tablets with a daily dose of 0.025 to 0.075 grams of clomipramine. Chronic painful feelings are treated with a daily dosage of 0.100 to 0.150 g, which is combined with concomitant analgesics, the amount of the latter can be gradually reduced.
To eliminate attacks of fear, at first use 0.010 g of the drug per day, which can be combined with benzodiazepine. If the medicine is well tolerated, then its amount is increased until positive changes appear. Then, the benzodiazepines are gradually phased out. Treatment with the drug "Clofranil" the instruction advises to cancel only after six months and not before. For this period of time, it is necessary to gradually reduce the maintenance dosage.
In old age, therapy is prescribed daily with a dose of 0.010 g. Then for 10 days the amount of the drug is increased to the optimal level, which is from 0.030 to 0.050 g. This dose is used throughout the therapy.
Adverse effects of
As with all antidepressants, it may cause side effects such as clofranil. The anticholinergic effect is manifested by a fuzzy visual process, paresis by accommodation, by the dilatation of the pupils, by raising the pressure inside the eye, by increasing the contractions of the heart, by the dry mouth, by the mind confused, by delirium, by constipation, by the inability of the bowel to paralytic, by the difficulty in emitting urine, and by the small separation of sweat. 
Changes in the nervous system are characterized by a drowsy, asthenic process that causes disorientation, anxiety, agitation, motor anxiety, manic or hypomanic changes. Also, side effects are characterized by aggression, memory failures, depersonalization, weak attention, insomnia, nightmares, asthenia.
Undesirable reactions of the heart and vessels are manifested by sinus uplift or changes in cardiac rhythm, collapse of the orthostatic appearance, conduction failure inside the ventricles, pressure variability.
"Clofranil" means application instructions describing changes in the digestive system, which are expressed by nauseating, hepatitis, icteric, heartburn, pain in the stomach, increased or decreased desire to eat, stomatitis, dental problems, changes in taste preferences, blackening of the surface of the tongue.
Hormonal disorders are characterized by swelling of the testicles, growth of the mammary glands in the male and an increase in women, an excessive dose of prolactin, galactorrhea, low or high sexual desire, impaired potency, hyper or hypoglycemia, hyponatremia, inadequate release of the antidiuretic hormone.
The change in the functioning of the hematopoietic organs is associated with a decrease in the number of leukocyte and platelet blood cells, purpura, and an increase in the number of eosinophils.
Allergic reaction in the form of a skin rash with itching, phobia of ultraviolet, angioedema edema can occur.
Adverse events are associated with a reduction in the scalp, petechiae, a warm or cold sensation, a delay or rapid urination, a decrease in protein concentration in the blood, febrile syndrome, and high fever.
As a result of a sudden discontinuation of the drug, nausea, vomiting, indigestion, headache, malaise, insomnia, and dreams can occur. Gradual reduction of the dose of the drug can make a person irritable, cause a state of motor anxiety.
For children
Obsessive-compulsive syndrome is treated with the initial dosage of 0.0125 g. For 14 days, a gradual increase in concentration is made, taking into account the tolerability of the medication. The daily dose after 2 weeks equals 0.100 g or it is calculated by the weight of the child, when for each 1 kg of weight there are 0.003 g of active substance. The next 14 days are accompanied by a gradual increase in the concentration of the drug to 0.200 g or recalculate by weight.
The appointment of the drug "Clofranil" for children is deserving of positive feedback in the treatment of nocturnal enuresis. The initial therapy is carried out in a daily dose of 0.020-0.030 g for the age of 5 to 8 years, for adolescents from 9 to 12 years, use 0.025-0.050 g;After 12 years, designate 0,025-0,075 g.
Dosage is increased by patients who did not benefit from the medication after 7 days after therapy. The entire daily dose of medication is prescribed to drink for one use in the evening after a meal. When involuntary urination in the evening during sleep, half the dosage is prescribed to drink up to 17 hours. When the desired effect is achieved, the drug is not discarded for another 90 days, during which a gradual decrease in the level of the drug is carried out.
Drug "Clofranil", analogues of
There are many drugs based on clomipramine hydrochloride, which are considered interchangeable. 
One such means is the Italian medicine "Anafranil", which is manufactured by Novartis Pharma. It also includes antidepressants of the tricyclic series. This psychotropic drug treats depressive processes and mental disorders. Preparations "Clofranil" and "Anafranil" in its composition have an active ingredient clomipramine in the form of a hydrochloride salt.
A medication is available in the form of tablets with regular and sustained release. Its simple dosage is 0.025 g, and retard contains 0.075 g of active ingredient. Conventional tablets have a light yellow sugar shell. Prolonged form of the drug contains a pink coating.
There is a liquid form of the drug, which is a solution for intramuscular and intravenous injection of 2 ml. The dosage of the injectable preparation "Anafranil" is 0.025 grams of clomipramine hydrochloride, which is dissolved in water by sterile and glycerol.
Another such remedy is the drug "Clomipramine", which is available in the form of tablets for oral use. To protect the mucous membrane of the digestive system, they are coated. The dosage is 0.025 grams of clomipramine hydrochloride. For its designation on each tablet is stamped "25".The drug is aimed at fighting the depressed state. The medication is dominated by psychostimulating, timoleptic and sedative activity. The latter function is associated with blocking the reverse neuronal capture of serotonin molecules, which improve the mood of the patient.
It is used for the therapy of depressive processes, which are caused by various causes. The drug is well treated with psychopathy, schizophrenia, phobias, panic disorders of an obsessive-compulsive nature, cataplexy, narcolepsy. Children after 5 years of age are appointed to eliminate night incontinence.
The "Clofranil" medication may contain an active substance other than clomipramine hydrochloride. For example, the drug "Soneks" in its composition has an active component zopiclone, which is contained in a single dose of 0.0075 g. The drug causes sleep onset, has a calming, anticonvulsant and miorelaxing effect. The overall quality of the drugs "Clofranil" and "Sonex" is their sedative property. 
Produced by the Belarusian pharmaceutical company Rubicon LLC in the form of tablets round, biconcave, with a white sheath coating and a risk for division in half. It is used to treat severe sleep disorders, with situational and temporary insomnia.
Drug "Truksal"
It is considered another similar analogue based on chlorprotixene hydrochloride, which is a thioxanthene derivative. Issued by the Danish company Lundbek JSC.The drug refers to neuroleptic drugs that have antipsychotic, pronounced sedative and moderate antidepressant activity.
There are four dosages of the drug: 0.005, 0.015, 0.025 and 0.050 grams. The first three doses are available in the form of brown tablets of biconvex and round shape with a shell coating. The largest dose is presented by an oval tablet with biconvex surfaces.
Antipsychotic activity is due to oppression of dopamine receptor formations. When these sites are blocked, the antiemetic and analgesic effect of the drug occurs. The drug inhibits 5-HT2-receptor associations, α1-adreno-and H1-histamine-dependent receptors, which causes adrenoblocking, antihistamine activity.
The medication is considered to be a neuroleptic medication of calming effect, which is intended for the treatment of psychotic, schizophrenic and crazy seizures.
It is used to eliminate childhood deviations in behavior, the goal is to overcome hangover withdrawal syndrome in alcohol and drug addiction, to combat hyperactivity, irritative process, confused consciousness in old age.
The drug is effective for depressive changes, sleepless, neurotic condition. 
Together with the analgesic medication, the drug "Truksal" eliminates painful processes.
Comparison of "Clofranil" with analogues of
The closest in action and composition is the drug "Anafranil" in the form of tablets with the usual release. Medicinal forms of retard with a dosage of 0.075 grams and a solution for intramuscular and intravenous use can not be compared with the Indian antidepressant, since it is not produced in this form.
Many patients are tormented by the question: what is the difference between "Clofranil" and "Anafranil"?First of all, there is a difference in the composition of inactive ingredients. The presence in the Indian preparation of brilliant blue, sodium carboxymethyl starch, hypromellose 2910, macrogol 6000, which is not present in the Italian medicine, speaks about the difference of the two analogues. These ingredients in the tablets "Anafranil" are replaced by acid stearic, glycerol 85%, hydroxypropylmethylcellulose, copolymer of vinylpyrrolidone and vinyl acetate, crystalline sucrose, polyvinylpyrrolidone K30, iron oxide yellow 5%, titanium dioxide, macrogol 8000.
The presence of both milk sugarbioavailability of the active substance. However, the presence of lactose makes them unsuitable for people who are intolerant of this component.
Different auxiliary ingredients of two analogues change the penetration, absorption, exposure and elimination of clomipramine hydrochloride from the body. They are also responsible for the development of all sorts of side effects.
The difference between Anafranila and Clofranil is related to price. The Italian drug costs a little more than the Indian counterpart.
If you compare that more: "Truksal" or "Clofranil", it is considered that the first medicine has a stronger sedative, calming and inhibitory effect, which allows you to overcome various psychotic disorders.
By the mechanism of influence, neuroleptics are very different from antidepressant drugs. The action of the drug "Truksan" is aimed at suppressing pathological psychic activity, reducing the work of neurotransmitter substances. With the help of the drug "Clofranil" their function is strengthened and stimulated.
Dopamine excretion is suppressed by neuroleptics, and the effect of antidepressants increases the production of this substance.
Opinions of patients
About the drug "Clofranil" reviews can be heard different. Many patients who are depressed, this tool helped to get rid of negative and obsessive thoughts, there was joy in life. 
Other people prescribed the medicine for alcoholism with severe psychological dependence. After a course of taking medication, the patient came in an adequate, calm, balanced state, aggression departs.
The preparation for "Clofranil" instructions for use of the reviews contains both positive and negative. This is due to the fact that the "Adverse Reactions" section contains a huge list of undesirable consequences that may arise during treatment. In practice, many doctors note the good tolerability of this drug, most importantly, choose the right dose and correct it on time if necessary.
Positive for the drug "Clofranil" reviews associated with the manifestation of its effectiveness in a timely manner, which are claimed by the manufacturer of the drug. Also, its availability in the financial plan pleases. The medication begins to function one week after the start of use, which is very important for the removal of an acute attack of the disease.
The disadvantage is that the drug can not be immediately withdrawn, and a gradual reduction in dosing is required.
Patients with panic disorder in early stages of therapy experience increased anxiety. This paradoxical feature manifests itself during the first day, and then decreases after two weeks.