"Ortanol": what helps, instructions for use, feedback

What is Ortanol Medication? What helps the medicine? The answers to these questions will be found below. In addition, we will present the price of the drug, its contraindications, analogs and form of release.

Packaging of the medicinal product, its composition, description, form

The preparation "Ortanol" is produced in the form of solid capsules with the size of No. 1 or No. 2. This product is white, and also the inscription "OME 20" or "OME 40"( depending ondosages).The contents of the medicinal capsules are yellow granules.

What does Ortanol mean? Reviews indicate that the main substance of the drug in question is omeprazole. It also has such auxiliary components as croscarmellose sodium, low-substituted giprolose, anhydrous lactose, microcrystalline cellulose, hypromellose phthalate, povidone, polysorbate 80, talc and dibutyl sebacate.

The capsule shell contains: propylene glycol, hypromellose, butanol, carrageenan, anhydrous anhydrous, shellac, potassium chloride, isopropanol anhydrous, titanium dioxide, ink for inscription and water.

In sale, the medication "Ortanol"( capsules) comes in blisters, packaged in packs of cardboard.

Action drug pharmacological

What is "Ortanol"( what helps this medicine, you will learn below)?According to the instructions, this preparation is an inhibitor of a proton pump. It reduces acid production, that is, it slows down the activity of K + -H + -ATPase in the stomach, or rather in its parietal cells. It also blocks the last stage of acid secretion by hydrochloric acid.

The drug "Ortanol", the price of which is listed below, is a prodrug. This agent is activated in the acidic environment of the tubules( secretory) parietal cells. In addition, it reduces the stimulated and basal secretion, regardless of the nature of the stimulus.

The antisecretory properties of this medication manifest within the first 60 minutes( maximum after 2 hours).Inhibition of 50% of maximum secretion continues throughout the day.

A single dose of the drug provides effective and rapid suppression of night and daytime gastric secretion. Its maximum reaches on the 4th day of therapy and disappears after three days after the end of treatment.

Kinetic properties of the drug

After taking the drug "Ortanol", it reaches a high absorption. The peak concentration of omeprazole in the blood is observed after 0.5-3 hours. Absolute bioavailability of the drug is 30-40%, and the connection of the drug with plasma proteins is 95%.

Metabolism omeprazole is carried out in the liver with the formation of six pharmacologically inactive derivatives.

The half-life of the drug is 0.5-1 hours. It is derived as a derivative by means of the kidneys( 70-76%) and together with bile( 18-24%).

In people with chronic liver diseases, the bioavailability of the drug is significantly increased, and the elimination half-life of plasma reaches 3 hours.

In patients with chronic kidney disease, excretion slows down. This happens in proportion to the decrease in QC.Medication "Ortanol": what helps?

This drug is indicated for use in the following diseases:

• reflux esophagitis;
• diseases of the gastrointestinal organs ulcerative( including for the prevention of relapses);
• states of hypersecretory( stress ulcers of the gastrointestinal tract, Zollinger-Ellison syndrome, systemic mastocytosis, polyendocrine adenomatosis);
• eradication Helikobakter Pilori in infected patients with gastric ulcer disease( in combination therapy);

• treatment and prevention of damage to the mucous membrane of the gastrointestinal tract, which are caused by the administration of NSAIDs( mucosal erosion, dyspepsia, peptic ulcer).

Prohibitions for the use of medication

What are the contraindications to the medication "Ortanol"( what helps this remedy, we described above)?According to the instructions, the medicine in question can not be used with:

• lactation;
• in childhood;
• hypersensitivity to drug substances.

With special care, the drug in question is prescribed for renal and hepatic insufficiency.

Medication "Ortanol": instruction

This medication is prescribed only by mouth. It is taken immediately before meals( usually in the morning, before breakfast).

The capsule with the medicinal substance is swallowed in its entirety, washed down with water. In the event that the patient can not use the whole medicine, its contents can be dissolved in a small amount of not very acidic liquid.

The dosage of this drug depends on the indications.

In case of duodenal ulcer 12 mg of medication is prescribed for 20 mg once a day for two weeks. In the event that, after the first course, complete scarring does not occur, a second two-week therapy is prescribed.

With ulcerative disease, resistant to treatment, this drug is recommended to take in a dosage of 40 mg once a day. The course of therapy with this drug can be extended to four weeks.

Capsules "Ortanol", the indications of which were listed above, with ulcerative lesions of the stomach take 20 mg once a day for four weeks. If, after the passed course, scarring does not occur, then a repeated four-week therapy is prescribed. With a gastric ulcer resistant to treatment, the drug is recommended to take a dose of 40 mg once a day( course up to eight weeks).

Helicobacter Pylori eradication is performed as a part of combined therapy. In this case, the medication is prescribed 20 mg twice daily before meals( for two weeks) in combination with antibacterial agents.

For reflux esophagitis, the drug is recommended to be consumed in an amount of 20 mg( once) for four weeks. If this method of medication is not conducive to complete cure, the patient is given a second course( four weeks).When severe form of reflux esophagitis therapy with this drug is extended to eight weeks.

In hypersecretory states, the medication prescribed for heartburn is administered individually. The recommended initial dosage for adults is 60 mg( once), and the maximum dosage is 120 mg.

When you prescribe a drug over 80 mg per day, it is divided into several receptions.

For damage to the mucous membrane of the digestive tract, which are caused by the intake of NSAIDs, and also for the prophylaxis of the capsule Ortanol, it is recommended to use a dose of 20 mg every day, before breakfast( throughout the course of NSAID treatment).

For the elderly and people with severe liver disease, the greatest daily dose of the drug is 20 mg.

For patients with impaired renal function, dosage adjustment is not required.

Side effects

What kind of reaction does the undesirable character of the drug "Ortanol"?Feedback on the following side effects:

• headache, visual impairment, dizziness, exudative erythema multiforme, paresthesia;
• drowsiness, nausea, taste disorders, diarrhea, insomnia, flatulence;
• excitation, dry mouth, depression, stomatitis, reversible confusion;
• encephalopathy, gynecomastia, hepatitis, peripheral edema, vomiting, photosensitivity;
• abdominal pain, thrombocytopenia, constipation, pancytopenia, increased activity of alkaline phosphatase and liver transaminase;
• skin itching, liver dysfunction, muscle weakness, the formation of gastric cysts glandular;
• alopecia, eosinophilia, increased sweating, bronchospasm, agranulocytosis, angioedema;
• , leukopenia, myalgia, fever, arthralgia, anaphylactoid reactions, urticaria, interstitial nephritis.

Adverse events that occur when the agent is used are mild and transient.

Cases of overdose of

When taking medication for heartburn, the patient may experience the following symptoms: headache, dry mouth, tachycardia, drowsiness, nausea, visual impairment, vomiting, confusion, increased sweating.

In such conditions, symptomatic therapy is performed.

Drug Interactions

When concomitant with omeprazole, the elimination half-life increases and the concentration of Diazepam, Warfarin, and Phenytoin increases, as well as other drugs that are metabolized in the liver with the participation of the CYP2C19 isoenzyme.

Absorption of products whose bioavailability is determined by the acidity of gastric juice( for example, Itraconazole, Ketoconazole, ampicillin esters, Cyanocobalamin and iron salts) may be impaired.

The bioavailability of digoxin in co-administration with omeprazole is increased by 10%.

This drug enhances the inhibitory effect on the hematopoiesis system of other drugs.

Clinically significant drug interaction with antacid medications, caffeine, "Theophylline", "Quinidine", "Propranolol", ethanol, lidocaine and "Metoprolol" is not established.

Specific recommendations of

Before starting treatment with omeprazole, a malignant process should be excluded. This is due to the fact that therapy with this drug can mask symptoms and delay the setting of a correct diagnosis.

Currently, there is no data on the impact of the funds in question on a person's ability to manage machinery and drive vehicles.

Cost and analogues

How much is an antiulcer medication like Ortanol? The price of this medicine is about 100-115 rubles. For most consumers, this cost is quite acceptable.

What can I replace the drug "Ortanol"?Analogues of this drug are presented in the form of "Omez", "Loseprazole", "Gaseka", "Omelika", "Omeprazole".

Reviews

Reviews about capsules "Ortanol" are more positive. Patients claim that this drug is an effective antiulcer. It quickly eliminates heartburn, as well as a feeling of heaviness and burning in the stomach.

Specialists claim that the medicine in question positively influences the course of diseases of the digestive tract only if it was prescribed by a gastroenterologist. Doctors say that it is forbidden to take this medication on their own, as it has a very strong effect.

Also to the positive side of this medicine include its availability and cheapness.