"Fraksiparin": instructions for use, reviews
What is the prescription for such a drug as "Fraksiparin"?Instructions for the use of the drug, its form and composition will be presented below. Also from the materials of this article you will learn about whether this drug has side effects and contraindications.
Form, Packing, Composition
In what packaging is the "Fraksiparin" medication on sale? Instructions for use indicate that the product is released in a syringe, which, in turn, is placed in a blister and cardboard pack.
Weak-palpating preparation for subcutaneous injection is a colorless and clear liquid. It may contain 9500, 5700, 2850, 3800 or 7600 IU of anti-Xa supraparin calcium. In addition, the composition of the medicament includes such additional substances as purified water, a solution of calcium hydroxide, hydrochloric acid.
Pharmacological and pharmacokinetic features of
What is the drug "Fraksiparin"?The instructions for use, applied to the drug, indicate that this is a very effective antithrombotic and anticoagulant.
The active substance of the drug is a low molecular weight heparin. It is obtained by depolymerization and shows a rather high ability to bind to plasma proteins. This effect leads to increased inhibition of factor Xa.
After subcutaneous injection, the maximum anti-Xa activity is observed after about five hours. The drug is absorbed by 88%.
If the medication was administered intravenously, its highest concentration in the blood is observed after about 10 minutes. The half-life is 2 hours.
The drug in the liver is metabolized by depolymerization and desulphation.
Indications for use
Why use the drug "Fraksiparin"?Instructions for use( photo medications you can find in this article) states that such medication is often prescribed to prevent thromboembolic complications, including after surgical and orthopedic surgical interventions.
Anticoagulant is recommended for people with a high risk of thrombosis, as well as suffering from respiratory or heart failure in acute type.
Contraindications to the use of
When is the recommended drug "Fraksiparin" not recommended for use? Instruction for use contains the following list of contraindications:
- affection of organs with the presence of bleeding;
- thrombocytopenia, developed against the background of the use of supraparin in the past;
- the age of a person under 18;
- bleeding or an increased risk of its development, associated with worsening of hemostasis;
- kidney failure, especially in severe cases;
- intracranial hemorrhage;
- infective endocarditis in acute form;
- surgery or trauma on the eyeballs, spinal cord or brain;
- hypersensitivity of the patient to drug substances.
One can not help saying that "Fraksiparin", whose reviews are ambiguous, should be taken with extreme care in renal or hepatic insufficiency, changes in blood circulation in the retina or choroid of the eye, arterial hypertension that occurs in severe degree, diseases withincreased risk of bleeding, peptic ulcers in the past, as well as when combined with other anticoagulants, after surgery and patients with a weight of up to 40 kg.
Preparation "Fraksiparin": instruction for the use of
With ECO, "Fraksiparin" is prescribed to improve blood rheology and facilitate implantation.
Use this medication only as directed by your doctor. It must be injected subcutaneously into the abdomen, alternating between the left and right sides. Thus the patient should be in a prone position. In some cases, the medication is injected into the thigh.
How to prick Fraksiparin? The needle must be inserted perpendicular to the crease of the skin, which is formed by the fingers of the free hand. In this case, the guard should be kept during the entire injection. After the injection, the injection site should not be rubbed.
What should be the dosage of the drug "Fraksiparin"?0.3 ml is prescribed to prevent thromboembolism in the surgical procedure( 2850 anti-XA ME).The medication is administered four hours before the operation, and subsequently - once a day. Treatment can be continued for at least one week or the entire period of risk of increased thrombosis( for example, before switching to outpatient monitoring).
Now you know the purpose for which the drug "Fraksiparin"( 0.3 ml) can be prescribed.
In addition to surgery, this tool is also actively used to prevent thromboembolism in orthopedics. It is administered subcutaneously to 38 anti-HA IU per kg of body weight. This dose can be increased by a factor of 1.5, but only on the fourth day after orthopedic intervention.
For people with a high risk of thrombus formation, the drug "Fraksiparin" is administered subcutaneously once a day in an amount calculated depending on the weight of the patient( at less than 70 kg, 3800 anti-Ha IU per day, and more than 5,700 anti-Ha IU).
In the treatment of thromboembolism, anticoagulants in the form of tablets should be given as soon as possible. Therapy "Fraksiparinom" does not stop until the goal of prothrombin time is reached.
Symptoms of an overdose of
Now you know how to prick Fraksiparin. It should be noted that with the use of increased dosages of this drug, the patient may experience bleeding of various locations. However, weak bleeding does not require urgent therapy( it is necessary only to lower the dose or postpone the next injection).
As for strong overdoses, protamine sulfate helps neutralize the anticoagulant effect of heparin. Its use is required only in severe cases.
Side effects of
What side effects can cause "Fraksiparin"?The patients' reviews say that such a drug promotes the development of bleeding of various localizations, thrombocytopenia, eosinophilia, an increase in the content of hepatic enzymes and hypersensitivity. Also, patients may develop small subcutaneous hematomas at the injection site. In these cases, treatment with "Fraksiparin" should be discontinued.
The risk of hyperkalemia is significantly increased when a given drug is combined with ACE inhibitors, potassium salts, angiotensin receptor blockers, potassium-sparing diuretics, Tacrolimus, heparins, Cyclosporin, NSAIDs and Trimethoprim.
It should also be said that the combination with acetylsalicylic acid, NSAIDs, indirect anticoagulants, "Dextran" or fibrinolytic mediates the effects of drugs.
Pregnancy and lactation period
Is it possible to take "Fraksiparin" during the pregnancy? Instructions for use in pregnancy( reviews on the drug will be presented below) states that the calcium supraparin( the active substance of the drug) quite easily penetrates the placenta. Also, this drug component is excreted together with breast milk.
In connection with all of the above, it should be noted that the injections of "Fraksiparin" when carrying a child and during breast-feeding are not recommended. However, in some cases, this drug still prescribed to patients.
So how to use the drug "Fraksiparin"?Instructions for use during pregnancy should be developed only by an experienced professional. Thus the woman should be on constant control at the doctor.
Analogues, the price of
The following drugs are the analogues of this drug: "Heparin-Pharmex", "Athenativ", "Enoxsarin", "Wessel Douay F", "Cibor", "Heparin", "Fragmin", "Heparin-Biolek"Flenox, Heparin-Darnitsa, Novoparin, Heparin-Indar, Kleksan, Heparin-Novopharm.
The price of the drug "Fraksiparin" is very high. For 10 syringes( 0.3 ml) you will have to pay about 2500 rubles.
Reviews about the drug
The patient's comments on the drug in question are ambiguous. Someone helped this medication very well, but someone complains about his inaction. In addition, there are quite a few reviews that "Fraksiparin" causes a large number of adverse reactions.
Experts do not recommend relying on the opinions of those who have already used this drug. The rationale for prescribing a medicament, its effectiveness and the risks associated with it, can be assessed only by an experienced specialist.
It should also be noted that there are no bad reviews about this drug during pregnancy.