Tablets "Agalates": reviews, instructions for use, prices
How does the Agalates drug work? Feedback on this drug, we will present in the materials of this article. Also, you will learn how to use this medication, how much it costs, whether it has side effects and contraindications, what it is intended for, and so on.
Composition, packaging, form of medical device
In what form is the Agalates medicament manufactured? Experts say that such a drug can be found in pharmacies only in the form of tablets. Their active substance is cabergoline. Also, the drug includes lactose, L-leucine and magnesium stearate.
Buy tablets "Agalates"( price, reviews are presented below) can be in dark glass jars, which are placed in packs of cardboard.
Pharmacological characteristics of the drug
Tablets "Agalates", whose reviews are ambiguous, are a synthetic ergot alkaloid. The active substance of this drug manifests itself as a dopamine receptor agonist. It inhibits the secretion of prolactin, stimulating the dopaminergic receptors of the hypothalamus.
The effect of the medication in question depends on the dose taken. Reduction of prolactin in the blood occurs after about 3 hours and lasts for 2-3 weeks.
During the treatment of hyperprolactinemia in men and women, the content of prolactin usually normalizes after 3-4 weeks.
How does Agalates work? Instruction, expert reviews inform us that this tool has a highly selective effect. However, it is absolutely safe and relatively well tolerated by patients.
One can not but say that as a result of taking the tablets in question, patients may have a decrease in blood pressure. And its degree depends on the dosage used. As practice shows, the hypotensive effect is observed only after a lapse of 6 hours( after administration).
Pharmacokinetic features of medicament
Now you know what the "Agalates" medication is. The instruction, price, reviews about this medicine are described in this article.
After ingestion, the drug is quickly absorbed from the digestive tract. In human blood it is determined after about 1-4 hours. About 42% of the drug binds to plasma proteins.
Almost all metabolites of cabergoline begin to inhibit the production of prolactin, but only to a small extent. The half-life of the drug is approximately 80 hours( 114 hours in patients with hyperprolactinemia).
In the urine of the patient who was prescribed this drug, the drug is detected in an amount of 18% of the used dose, and in the stool - about 72%.
Indications for the use of the drug
What are the purposes of taking Agalates tablets? Testimonials of experienced specialists indicate the following indications:
- amenorrhea, anovulation, galactorrhea and oligomenorrhea, which are directly related to hyperprolactinemia;
- idiopathic hyperprolactinaemia;
- prolactin-benign secreting adenomas of the pituitary gland;
- oligomenorrhea, unspecified.
It should also be noted that this medication is prescribed to suppress postpartum or already established lactation.
Contraindications to the use of medication
What contraindications should a patient know before using Agalates medication? Physicians' reviews particularly point to the following inhibitions:
- hypersensitivity to the components of the medication;
- postpartum arterial hypertension;
- lactose intolerance;
- disorders in the functioning of the liver;
- psychosis in the anamnesis;
- adolescence( up to 16 years);
- eclampsia and preeclampsia;
- application of antibiotic agents - macrolides;
- heart valve lesions, which arose against the background of cabergoline therapy.
Preparation "Agalates": instructions for use
Price, reviews about this medication you can see at the very end of the article. With regard to this section, in it we will tell you how to use the drug in question.
To treat hyperprolactinemia appoint 0.5 mg of the drug per week. Take it in one or two doses. After that, the dosage is increased. For the first month of treatment, the amount of medication can be increased by another 0.5 mg.
When using a drug more than 1 mg per week, it should be divided into several receptions( 2-3).The highest dose per week is 4.5 mg. As supportive, 1 mg is used.
It should be specially noted that the experience of treating elderly people( over 65 years of age) with this remedy has not been studied. Therefore, you can take the medicine at this age only under the strict supervision of the doctor.
How do you use Agalates medication for other indications? Reviews( cessation of lactation occurs after taking the 1st pill), specialists say that it is necessary to take such a remedy only after consulting a specialist( obstetrician).To completely stop the established lactation medication is prescribed in a dosage of 0.25 mg twice a day. Take this medication should be for two days.
If it is required to stop lactation after childbirth, then the patient is given 1 mg of the drug immediately after the birth of the child.
Symptoms of an overdose of the drug "Agalates"
To date, cases of overdose have not been documented. Although in the case of the use of a large amount of medicine, there is a possibility of vomiting, nausea, psychosis, lowering blood pressure or hallucinations. When expressed signs of an overdose, it is necessary to prescribe medications such as Domperidone and Bromopride.
Adverse events after taking medication
What side effects occur after taking this medication? If the drug was used to suppress or prevent lactation, then the unwanted consequences such as severe dizziness, nausea, headaches, abdominal pain, a slight decrease in blood pressure, and drowsiness may appear.
With the systematic administration of tablets( during the treatment of hyperprolactinemia), headaches, asthenia, nausea, dizziness, gastritis, indigestion, constipation, abdominal pain, breast tenderness, vomiting, lowering blood pressure, hot flashes, depression and paresthesia may also occur.
If treatment with Agalates has been delayed, patients may complain of the following side effects when taking long tablets:
- skin rash;
- sleep disorders, hallucinations, dizziness, headache, drowsiness, increased libido, depression;
- nausea, dyspepsia, abdominal pain, epigastric pain, constipation, vomiting;
- disorders in the functioning of the liver;
- heartbeat, hypotension, pericarditis with effusion, angina pectoris, damage to heart valves, peripheral edema;
- weakness, asthenia;
- pleural effusion, shortness of breath;
- vision impairment.
Agalates tablets should not be taken with dopamine receptor antagonists such as Phenothiazine, Metoclopramide, and Thioxanthene.
It should also be noted that it is forbidden to prescribe the drug with macrolides. This is due to the fact that there is a high probability of an increase in the concentration of cabergoline in the blood. In addition, it is highly recommended not to take the drug for a long time at the same time with other ergot alkaloids.
With special care, "Agalates" pills are prescribed together with antihypertensive drugs. No drug interaction with "Levodopa" was found.
With special care, Agalates is prescribed for patients with Raynaud's syndrome, cardiovascular diseases, gastrointestinal ulcer, renal dysfunction, internal bleeding, serious psychiatric disorders in the history, and in conjunction with the use of antihypertensive drugs.
To prevent or suppress lactation, it is highly discouraged to prescribe this medication to patients with preeclampsia and during postpartum hypertension.
Agalates: feedback from
Discontinuation of lactation( need to be expressed before taking the pill) is the main indication for the use of this medication. According to the patients' reviews, this drug copes with the task rather effectively.
Most women with hyperprolactinemia respond to the drug "Agalates" only on the positive side. According to them, the course of treatment with this drug brings in order practically all tests.
Also, patients say that this medication is tolerated fairly well by them. However, there are also such reviews, where the fairer sex complains of the occurrence of dizziness and headaches. In this case, doctors recommend either canceling the medicine, or replacing it with a safer means of health.
How much is the drug Agalates? This medication is quite expensive. In pharmacies in Moscow and the Moscow region the price of two tablets of 0.5 mg can range from 330 to 470 rubles.