"Bereta" tablets: instructions for use, indications, analogues, manufacturer, reviews

According to the instruction, Beret tablets are among the antiulcer drugs and are an inhibitor of H-K-ATPase or a proton pump. This drug acts by inhibiting the enzyme H-K-ATPase in the parietal gastric cells, so that the final stage of the formation of hydrochloric acid is blocked. Such action is characterized by dose-dependence and inhibits not only basal, but also stimulated secretion of hydrochloric acid, regardless of the nature of the stimulus.

Form, package and composition

Beret is a drug used for acidity disorders. It is produced in the form of biconvex round tablets, having a shell, which dissolves in the intestine. In addition, two layers are provided on the transverse section. Color - yellow with a grayish tinge. Its pharmaceutical company Veropharm( Russia) produces.

Active ingredient of the drug is sodium rabeprazole, additional components are substances of giprolose and giprolose low-substituted, mannitol, magnesium stearate and magnesium oxide. The inner shell contains magnesium oxide and ethyl cellulose.
beret tablets instruction

The shell dissolving in the intestine contains acrylic yellow with the included methacrylic acid copolymers, and titanium and silicon dioxide colloidal, iron dye yellow oxide, sodium lauryl sulfate, sodium bicarbonate, triethyl citrate. This is confirmed by the "Bereta" tablets instructions for use. Analogues will be presented below.

Sold in pharmacies in cardboard packs with enclosed in them contour packs containing seven and ten tablets. There are either two packages in a pack, or one, but containing fourteen tablets. In addition, they contain a polymer bottle with twenty or fourteen tablets.

The drug is allowed to be stored for two years after it is manufactured. The temperature should not be above twenty-five degrees. To the place where the drug is stored, children's access should be limited. What else tells the instructions to the Beret tablets? Let's figure it out.

Pharmacology

Bereta is a remedy for ulcers and acts as an inhibitor of a proton pump. The mechanism of the drug's functioning is based on the process, under the influence of which the enzyme of the pump in the particular gastric region is inhibited, and as a result the final stage of acid formation is blocked.
Veropharm Russia

Pharmacokinetics

After Beret's medication has been taken, it is absorbed from the digestive tract. The therapeutic effect of a dose of twenty milligrams reaches a culmination in three and a half hours."Beretta" is bioavailable at about fifty-two percent, as it passes through the liver. But repeated use of the drug does not promote the growth of bioavailability. This indicates the instructions to the Beret tablets.

The absorption of the drug is also not affected by the time of its intake and food.

A component such as rabeprazole responds ninety-seven percent for its association with plasma proteins. Metabolism of this drug is carried out in the liver with the participation of certain isoenzymes.

In older patients, rabeprazole is slower. What are the indications for the Beret tablets? This will be discussed later.

Indications for use

The drug is prescribed for patients suffering from gastric ulcer and duodenal ulcer. Especially it is recommended for their exacerbations. Most often it is taken in combination with certain antibiotics. In addition, this drug is prescribed in the presence of gastroesophageal reflux in children. beret tablets instructions for use analogues

Contraindications

The drug should not be used by pregnant women and nursing mothers, as well as patients who have a specific sensitivity to the main components of the drug.

Instruction for the use of

According to the instructions, Beret tablets are indicated for internal administration, with a single dose ranging from ten to twenty milligrams. Depending on the individual characteristics of the disease, the doctor will prescribe a treatment regimen for the patient.

Negative consequences of application of

Beret has a very impressive list of side effects from their use, and they must be taken into account in the process of prescribing this medication to the patient.

The digestive system can respond as follows:

  • attacks of nausea, diarrhea, vomiting, pain in the abdomen, constipation, flatulence;
  • less likely to feel dry mouth, there are burping and dyspepsia;
  • in a few cases, gastritis, anorexia, stomatitis and an increase in liver transaminase activity were noted.

gastroesophageal reflux in children
The nervous system can respond by the following reactions:

  • headaches, insomnia, dizziness, asthenia;
  • less often - drowsiness, nervousness;
  • in very rare cases - defects of taste sensations and visual, depression.

On the part of the respiratory system:

  • may appear rhinitis, cough, pharyngitis;
  • in more rare cases, bronchitis, sinusitis are possible.

Allergic reactions:

  • very rarely skin rashes may appear;
  • in rare cases, itching may occur.

Other side effects:

  • pain in the back, flu-like syndrome;
  • very rarely - pain in the chest, muscle cramps, chills, myalgia;
  • in isolated cases, increased sweating or the occurrence of leukocytosis, weight gain. beret price

The nature of interaction with other drugs

If you take Beret tablets along with ketoconazole, the characteristics of its bioavailability will decrease. If they are taken together with digoxin, then an increase in the concentration of this drug in the plasma is possible.

Effects on the level of gastrin in the plasma

In clinical trials, patients received ten or twenty milligrams of rabeprazole sodium every day. The duration of therapy is up to forty-three months. At the same time there was an increase in the level of gastrin in the plasma during the first two to eight weeks, which is an indicator of the inhibitory effect on acid secretion. To the initial state, the concentration of gastrin returned mainly in one to two weeks after completion of therapy. This is important in the treatment of gastroesophageal reflux in children.

Influence on enterochromaffin-like cells

During the analysis of human stomach biopsies from the antrum and gastric floor in 500 patients who received either sodium rabeprazole or a comparator for eight weeks, no changes of a stable nature were observed in the morphological structure of the level of gastritis, metaplasia of the intestine, the frequency of gastritis atrophic or the prevalence of the bacterium Helicobacter pylori.

With participation in the study, more than four hundred people who took rabeprazole sodium ten or twenty milligrams per day for one year, there was a low incidence of hyperplasia, equal to that of omeprazole( twenty milligrams per kilogram).No cases of adenomatous transformations or carcinoid tumors that were observed in rats were recorded. beret pills reviews

Some recommendations of

Before starting therapy, it is necessary to eliminate the presence of malignant gastric neoplasms, since the use of rabeprazole is able to disguise the characteristic symptoms and postpone the correct diagnosis for some time. If the patient has defects in the functioning of the kidneys or the liver, adjust the dose is not necessary, with severe disruption of the liver should be used rabeprazole with caution.

If digoxin and ketoconazole are taken concurrently with rabeprazole, the dose needs to be adjusted.

There was no carcinogenic effect of rabeprazole under experimental conditions, but the results of the ambiguous nature were noted during the mutagenicity study. In mice, tests on lymphoma cells gave a positive result, while DNA in vitro and in vivo and in vivo microinuclear tests were negative. This is confirmed by the "Bereta" tablets instructions for use.

Analogues of the drug

Tablets have similar drugs, similar in pharmacological effect, but their cost is much higher. These include the following medicines:

  • "Zulbek".
  • Pariet.
  • "Noflux".
  • "Ontime".

All these products are also available in the form of tablets.

Manufacturer of Bereta

The manufacturer of this drug is OJSC Veropharm( Russian Federation).This joint-stock company manages all stages, including issuing quality control. Pharmaceutical substance, namely rabeprazole sodium, is produced by the Indian manufacturer "Nosh Labz Pryvet Limited".Let's consider, what there are responses about tablets "Beretta".
beret medicine

Reviews

It should be noted that there are not too many reviews about Bereta, and therefore it is rather problematic to draw any definite conclusion about the effectiveness of the drug's influence, as well as the safety of its use. However, references to rabeprazole, which is an active ingredient, suggest that this drug should act fairly quickly, even if small doses are used. The undoubted merit of the Beret tablets is a small number of manifestations of side effects and a widely available price in comparison with the price of analogues.

The positive effect of the drug on acidity and a decrease in reflux is noted. Quite well it helps to correct hemorrhagic gastritis. In some reviews, the temporary effect of the drug is noted, in such cases a course of other tablets was required.

Price

"Beret" is different from similar expensive drugs in that it has a fairly reasonable cost, which is an average of not more than two hundred and fifty rubles.