"Flemoklav Solutab" 875/125: instructions for use

There are hundreds of different antibiotics on the Russian pharmaceutical market, both domestic and imported. They are all designed to fight bacterial infections. There are synthetic, semi-synthetic antibiotics and natural antibiotics. The latter cause the least amount of side effects. But their action is directed, as a rule, against a small group of microbes.

There are also unprotected antibiotics and protected ones, which contain additional substances that prevent bacteria from protecting themselves from the deadly effect of the main therapeutic substance. What is special about it? Protected antibiotics can cope not only with a wide variety of infections, but they have more side effects than their unprotected counterparts.

In this article we will talk about the new protected semi-synthetic preparation "Flemoklav Solutab" 875/125.The instruction to him explains how to use it, but not all medical terms in it can be understood by a wide range of people. We offer a detailed review of this drug, as well as an analysis of reviews of patients and doctors directly working with this drug.

General information

The instruction accompanying each package "Flemoklava Solutab" 875/125 tells what is produced by its Dutch company, known on the Russian pharmaceutical market and called "Astellas Pharma Europe BV".

The drug is an antibiotic with the widest possible spectrum of action. It is produced in cardboard packages. Each pack contains only 2 blisters. In each of them 7 packs are packed in hermetically sealed cells. They are quite large in size, oblong, convex, do not have separation risks( that is, their division into parts during use is not provided).They have a company logo and numbers "424".This knowledge will help you to distinguish a natural drug from a fake. fleumoclave solyutab 875 125 instructions

The color of the Dutch tablets should be either white or yellow-cream with brown impregnations. Their taste is quite specific, as reported by all respondents in their responses. For complete clarity of the picture, we present several photos of "Flemoklav Solutab" 875/125.The instruction prescribes tablets or swallows, washed down with water, or dissolved in water( 100-150 ml) and drunk as a resulting suspension, since the drug belongs to the category of dispersible drugs.

Let us explain what this medical term means. Dispersible tablets are such medications that you do not need to swallow with water. They can dissolve in the mouth, and they can be dissolved in water and make a drug similar to a suspension. This kind of tablets was invented for patients suffering from dysphagia( having problems with swallowing), as well as for everyone who is more comfortable with this form of taking medicines.

Therefore, the taste of such a preparation is of great importance."Flemoklav Solutab" is produced in two types. To be more precise, it is with lemon and orange flavor. If the flavoring agent of the tablets does not suit you at all and causes vomiting in the form of a suspension, it is allowed to add honey or sugar to the solution. It is also allowed to take this medicine with any product that you like( for example, with whipped fruit in the blender.)

You can buy the drug at any pharmacy, but only with the prescription of a doctor. When buying the drug, pay special attention to the numbers following the name of the drugmeans and always indicated on the packaging. The fact is that the "Flemoklava Solutab" Dutch company produces in several kinds.

So, there are tablets of this drug with dosages of amoxicillin and helping him to destroy the tankclavulanic acid in the following proportions: 500/125, 250 / 62,5 and 125 / 31,25 All of them have the same therapeutic properties, but if a package with a lower concentration of essential medicinal components is purchased, the physician should adjust the dosage of the drug

Preparationwith the concentration of basic substances 875/125 costs from 380 to 490 rubles, which depends on the mark-up of pharmacies caused by transport and other costs. instruction of the fleumoclave solyutab 875 125

Chemical Composition

The instructions to "Flemoklava Solutab" 875/125 indicate that the basic substances acting protThere are only two bacteria in the preparation:

  1. Amoxicillin. It contains 875 mg in each pill.
  2. Clavulanic acid: it is in 125 mg pills.

The figures on the packaging "875" and "125" indicate exactly the content of these substances in the preparation. Additionally, each tablet contains:

  • vanillin( 1 mg);
  • magnesium stearate( 5 mg);
  • saccharin( 9 mg);
  • crospovidone( 100 mg)
  • cellulose microporous 327 mg;
  • apricot flavor.

Instruction for "Flemoklava Solutab" 875/125 description of each component does not. We will fill this gap so that patients have an idea what comes into their bodies with each pill of the drug.


This is an antibiotic from the penicillin group. It belongs to the third subgroup, called aminopenicillins, and is a complex compound that includes, in addition to synthetic penicillins, substances such as ticarcillin and carbenicillin. This explains the unusually wide range of microorganisms with which it is able to fight.

The principle of their action is to destroy the walls of bacteria by blocking the synthesis of their main component - peptidoglycan. fleumoclave solutab 875 125 application instructions

According to the instructions to "Flemoklava Solutab" 875/125, in the composition of tablets, the drug amoxicillin takes a leading position. It should be borne in mind that although this substance is highly active against pathogenic microorganisms and for most people it is completely harmless, in some patients it can cause allergic reactions: rash, laryngeal edema, fever up to 38 ° C, abdominal pain, digestive disorder, even dangerousonly for health, but also for life anaphylactic shock. In rare cases, patients experience vomiting, skin flaking, dizziness.

It should also be noted that such a strong antibiotic, like amoxicillin, with long-term use can destroy not only pathogenic bacteria, but also beneficial, inhabiting mucous membranes. This disturbs the normal balanced composition of the microflora, which ensures that the tissues fulfill their functions. This can provoke the emergence of dysbiosis, and women in addition the appearance of such diseases as bakvaginosis and candidiasis of the vagina.

Clavulanic acid

As the instruction "Flemoklava Solutab" 875/125 informs, in the composition of the preparation about 1/5 part the clavulanic acid occupies. This substance is an inhibitor of beta-lactamase enzymes. They are produced by many bacteria in order to ensure their resistance against antibiotics. By suppressing the activity of these enzymes, clavulanic acid reduces the resistance of microbes and enhances the antimicrobial function of antibiotics. In addition, this component is capable of destroying certain types of bacteria: streptococci, chlamydia, staphylococci, genococci, legionella. Working in pairs, clavulanic acid and amoxicillin are active against bacteria such as:

  • streptococci( viridians, pyogenes, anthracis, pneumoniae);
  • of staphylococci( aureus, epidermidis);
  • enterococci;
  • of Corynebacterium;
  • clostridiums;
  • peptococci;
  • peptostreptococci;
  • shigella;
  • Bordetelles;
  • gardnerelles;
  • Klebsiella;
  • salmonella;
  • Escherichia;
  • proteomes;
  • Helicobacter pylori.

This information is provided in the instruction "Flemoklava Solutab" 875/125.However, there it is not indicated that acting together, amoxicillin and clavulanic acid used with it activate the intracellular bactericidal activity of leukocytes, stimulate their chemotaxis( movement to the source of the lesion) and adhesion of leukocytes( cell adhesion).All this greatly enhances the effect of the drug. Especially these useful properties are manifested in the treatment of respiratory infections caused by pneumococcal bacteria. fleumoclave solyutab 875 125 instructions

Additional substances in the preparation

Crospovidone .This substance in Russia is called povidone. It belongs to the group of enterosorbents. Its properties are complex formation. That is, povidone actively binds toxins: both coming from outside, and formed in the process of various reactions in the body itself. He does not enter the blood, he works only in the organs of the digestive tract. At the same time, the mucous membranes do not break, they do not accumulate in the cells, they are excreted with dead masses.

Povidone is added to the "Flemoklava Solutab" tablets to adsorb toxins released by pathogenic bacteria, and to remove other harmful substances from the body during metabolic reactions, thereby improving the therapeutic effect of the essential medicinal components.

However, in some cases, povidone reduces the absorption of drugs. To ensure that this does not occur when taking the drug in question, it accurately verified its quantitative content. There is no contraindication to povidone, but in rare cases it can cause nausea and vomiting.

Cellulose is microporous. According to the instructions to "Flemoklava Solutab" 875/125, this substance in tablets is almost three times larger than that of crospovidone. Microporous cellulose is a polysaccharide, it is not absorbed, is not digested, does not cause allergic reactions. Once in the organs of the digestive tract, it, like a sponge, absorbs pathogenic organisms, that is, acts as a sorbent.

Magnesium stearate .Used as a filler and a shaper.

Other components of the drug give the tablet their taste. fleumoclave solyutab 875 125 instructions doctors


As described in the manual, the drug "Flemoclav Solutab" 875/125 is effective in the following diseases:

  • respiratory infections( pneumonia, bronchitis, lung abscess);
  • of ENT organs( otitis media, pharyngitis, sinusitis, tonsillitis);
  • skin infections( erysipelas, dermatoses, impetigo, wound infections, phlegmon, abscesses);
  • osteomyelitis;
  • infections of the urinary and reproductive systems( cystitis, pyelitis, cervicitis, pyelonephritis, salpingitis, prostatitis, urethritis);
  • some venereal diseases( gonorrhea, soft chancre);
  • complications in obstetrics and surgery( postpartum sepsis, infection after surgery, septic abortion).


In the description of the preparation "Flemoclav Solutab" 875/125 the instruction informs that, having got into the stomach, clavulanic acid and the main drug of this medicine quickly penetrate into the blood. The maximum plasma concentration for amoxicillin is 1.5 hours( 12 μg / ml).Its absorption is 90%( with oral administration).Approximately 20% of this substance binds to proteins present in the blood plasma.

It has been experimentally determined that the half-life of a substance such as amoxicillin is 1.1 hours. It is excreted by the kidneys in an almost unchanged form, and approximately 80% are removed from the body within 6( maximum 6.5 hours) after the tablet has been drained.

For clavulanic acid, the time to reach the maximum( 3 μg / ml) of plasma concentration is 1 hour. In the stomach, it absorbs about 60%, and about 22% is associated with plasma proteins. In the human body, this substance is metabolized by hydrolysis and decarboxylation reactions. That is, it is already output in a modified form. And in the first 6-6,5 hours from the body it is removed about 50%.

Dosage and reception rules for

Consider how to take "Flemoklava Solutab" 875/125.In the dosage instructions and methods of admission are indicated the following:

  1. For children from 12 years of age, the drug is allowed 1 tablet in the morning and 1 tablet in the evening. In which hour it is not so important. The main thing is that there should be at least 12 hours between meals. In the reviews, most patients indicate that they took the medication at 8 am and 8 pm.
  2. Children who are less than 12 years of age, but weigh 40 kg or more, can also take tablets containing 875 mg of amoxicillin( "Flemoklava Solutab" 875/125).Instruction prescribes to give such children also 2 tablets per day: 250 mg for children under 2 years, 500 mg for all others. Babies should be given a medicine in the form of a syrup or a sweet suspension. flemoclave solutab 875 125 instruction description of the preparation

Adults should take the drug in the same way that children over 12 years, that is, on a pill morning and evening.

Drug intake during meals does not affect the absorption of active ingredients. However, many patients note that the medicine is better perceived by the body, if taken directly before the start of the meal.

The duration of treatment is determined by the doctor, based on the severity of the disease. In most cases, the course does not exceed 14 days, but under special circumstances it can be longer.

For people suffering from renal insufficiency of any degree, the dosage of the preparation "Flemoclav Solutab" 875/125 can be adjusted. Instructions for use reads if the patient's speed, the so-called glomerular filtration exceeds 30 ml / min, only then he is given doses and multiplicity of intake on general grounds. In other words, 1 tablet in the morning and evening hours.

If the filtration rate is less than 30 ml / min, the excretion of clavulanic acid and amoxicillin by the kidneys is slower. Therefore, the patient is reduced the dose of the drug( prescribe "Flemoklav Solutab" with 500 mg of amoxicillin or can be used with 250 mg).If the filtration rate is less than 30, but exceeds 10 mg per minute, the drug is taken 2 times a day, and if less than 10 mg / min - 1 time per day.

If the patient has renal failure, the drug is prescribed only if it is possible to continuously monitor liver function.

To those patients who undergo hemodialysis, "Flemoclav Solutab" is not contraindicated. Such people are prescribed a drug with an amoxicillin content of not more than 500 mg. Orally, tablets are taken either twice a day( before the procedure and after), or once a day. It depends on the condition of the patient.


Like other medicines, a number of contraindications has also the preparation "Flemoklav Solutab" 875/125.The instruction says that it can not be taken to the following categories of patients:

  • with hypersensitivity to any components included in the formulation;
  • having an allergy to any penicillin group drugs;
  • to those who have liver dysfunction after application of the drug, eye whites and skin integrate yellow;
  • suffering from infectious mononucleosis;
  • for patients diagnosed with lymphocytic leukemia;
  • with a measles-like rash on the body;
  • for phenylketonuria.

Recall that a drug with a concentration of basic substances 875/125 can not be taken for children under 12 years old and suffering from kidney failure. This takes into account the rate of glomerular filtration, which should not be less than 10 mg / min.

Some categories of patients can be cautious and only under the supervision of a doctor to take the drug "Flemoklav Solutab" 875/125.The instructions for use indicate the following categories of such patients:

  • having gastrointestinal diseases;
  • patients with colitis;
  • with renal insufficiency in chronic form;
  • with hepatic insufficiency in severe stages;
  • during pregnancy;
  • during breastfeeding.

Breastfeeding mother can use such a medicine for herself. But if the baby has diarrhea or candidiasis mucous, the drug is canceled. medicine fleumoclave solyutab 875 125 instructions


Above mentioned side reactions that may appear on each component included in the "Flemoclav Solutab" 875/125 have already been mentioned. In the instructions for use of the drug, it is reported that, in general, the substances included in this drug can cause the following undesirable reactions:

On the part of the digestive system:

  • nausea;
  • dysbacteriosis, manifested by diarrhea;
  • vomiting;
  • hemorrhagic colitis;
  • enterocolitis;
  • hepatitis;
  • gastritis;
  • cholestatic jaundice.

On the part of the organs responsible for hematopoiesis:

  • thrombocytosis;
  • for leukopenia;
  • hemolytic anemia;
  • thrombocytopenia;
  • granulocytosis;
  • eosinophilia.

From the CNS side:

  • headaches;
  • convulsions;
  • dizziness;
  • is an unexplained anxiety;
  • difficulties with falling asleep.


  • hematuria;
  • candidiasis;
  • Crystalluria;
  • interstitial nephritis.

In some patients, the information presented in the instructions for "Flemoclav Solutab" 875/125 causes considerable concern. In the responses of doctors to the drug also comments on too large a list of adverse reactions to this drug. We add that its use in many adults and children can cause a number of allergic manifestations:

  • rash on the skin;
  • Stevens-Johnson syndrome;
  • exudative erythema;
  • acute exanthematous pustulosis;
  • allergic vasculitis;
  • edema;
  • exfoliative dermatitis;
  • anaphylactic shock.

Interaction with other medicines

Not all drugs can be used, according to the instructions, "Flemoclav Solutab".In the reviews, patients note that doctors did not always warn them about this, resulting in unwanted reactions of the body:

  • Sulfonamides, lincosamides, macrolides, tetracyclines produce antagonistic effects.
  • Glucosamine, antacids, laxatives reduce absorption, and ascorbic acid increases it.
  • Diuretics increase the amount of amoxicillin in lymph.
  • The drug reduces the effectiveness of oral contraception.


The preparation "Flemoklav Solutab" 875/125 has a lot of analogues, which have similar antibacterial effect. Among them you can name:

  • "Panklav".
  • "Ecoclave".
  • "Augmentin".
  • Arlet.

They are produced with a different quantitative content of the main components. Therefore, the dosage and methods of administration may differ from those prescribed for "Flemoklava Solutab".For the treatment of analogues to be effective, it is necessary that the possibility of their use be determined by the attending physician. He should prescribe dosage.

"Flemoclav Solutab" 875/125: about instructions, reviews of doctors and patients

In general, such a drug deserves attention and trust. Doctors-therapists and specialists of a narrow profile prescribe it quite often, since in most cases the effect of therapy is predictably high. With the help of such a drug it is possible to cure patients from many serious bacterial infections and thereby avoid their complications. Also, doctors note that such a drug has proven itself in the prevention of postoperative complications.

Patients have a slightly different opinion about the preparation "Flemoklav Solutab" 875/125.In the responses to the instructions attached to the packages of the remedy, people note that it is sometimes difficult to understand when and how to give the drug to children.

But most of all negative reviews are written about multiple adverse reactions, due to which it is necessary to interrupt treatment. In positive responses, patients who did not experience any complications during taking the drug noted the high efficiency of Flemoclav Solutab and its relatively low cost, which makes this medicine affordable for people with different income levels.