The drug 'Famotidine'.Instructions for use
The drug "Famotidine" is a medicine used for gastrointestinal diseases. It is a competitive histamine antagonist."Famotidine", the mechanism of its action is directed to H2 histamine receptors in parental cells, significantly reduces the production of hydrochloric acid, provoked by different stimuli. Secretion of pepsinogen is inhibited in a smaller volume. The drug "Famotidine" provokes a dose-dependent suppression of the production of hydrochloric acid and a decrease in the activity of pepsin. When taking the medicine, there is a significant change in the level of gastrin in the plasma.
The duration of the effect after a single use of the drug depends on the dosage. Typically, the duration of the action - from twelve to twenty-four hours.
The "Famotidine" tool recommends the use of adults for exacerbation of ulcers of the duodenum or stomach, erosive gastroduodenitis, symptomatic ulcers once a day for forty milligrams or twice a day for twenty milligrams. In agreement with the doctor, if necessary, daily dosage may be increased to 80-160 mg. Duration of treatment - from one to two months.
To eliminate signs of dyspepsia, provoked by a strengthened secretory gastric function, the "Famotidine" preparation instruction recommends the use of twenty milligrams one or two times a day.
To prevent the recurrence of peptic ulcer, once a day, 20 mg( per night) is prescribed.
Treatment of reflux esophagitis is carried out by applying the drug at a dose of 20-40 mg twice a day. Duration of therapy - from one and a half to three months.
The preparation "Famotidine" instructions for use allows for the appointment of children from three years of age. The recommended dose is 2 milligrams per kilogram of weight( at a weight of more than ten kilograms) or 20 mg twice a day, but not more than 40 mg.
Among the side effects when taking "Famotidine" instructions for use notes the development of acute pancreatitis, hepatitis, increased activity of hepatic enzymes, anorexia. The drug can provoke flatulence, dry mouth, diarrhea, flushing, hallucinations. Negative effects include psychosis, nervousness, depression, drowsiness, fatigue, tinnitus. Probably the appearance of dizziness, insomnia. Side effects include atrioventricular blockade, arrhythmia, bradycardia, vasculitis, lowering of pressure, bronchospasm, acne, dry skin, hypersensitivity reactions.
With continued medication "Famotidine" impotence is noted, in the blood the urea concentration rises, libido decreases, articular, muscle pains, febrile conditions occur.
It should be excluded before the beginning of therapy that the patient is likely to have malignant tumors in the duodenum, esophagus or stomach, due to the ability of the drug "Famotidine" to hide symptoms.
After the ulcer symptoms have been eliminated, it is recommended that the treatment be continued until the results of the X-ray or endoscopy study confirm scarring.
The drug "Famotidine" should be withdrawn gradually, due to the likelihood of the syndrome "bounce".
Prolonged treatment, as well as finding a patient under stress during therapy, can provoke stomach lesions of a bacterial nature with the subsequent spread of the infectious process.
When overdosed, there is a collapse, tachycardia, tremor, hypotension, motor excitement. It is necessary to rinse the stomach or induce vomiting. Subsequently, symptomatic therapy is indicated.
To the analogues of means "Famotidine" include such drugs as "Atodine", "Acipept", "Famocid", "Gastrozidin" and others.