"Vigantol" preparation: instructions for use, analogues and reviews
Why do you need a medicine like "Vigantol"?Instructions for use and analogues of this drug will be presented below. Also we will tell you in what form this medication is issued, how much it costs, whether it has side reactions and contraindications.
Composition, packaging, shape, description
What is "Vigantol"?Instructions for use, applied to the drug, states that this drug regulates the exchange of phosphorus and calcium in the human body. It is available as a clear, oily solution for oral administration. The drug has a slightly yellowish color and a viscous consistency.
In 1 ml of this drug contains 500 μg of colcalciferol, as well as auxiliary substances in the form of medium chain triglycerides. The drug goes on sale in 10 ml bottles made of dark glass and having a stopper-dropper.
Pharmacodynamics of the drug
How does the drug "Vigantol" work? Instructions for use indicate that this drug has a regulating phosphoric-calcium metabolism of pharmacological action. At the same time, he replenishes the lack of vitamin D3, increases absorption of calcium in the digestive tract and reabsorbs the phosphates in the kidneys.
In addition to all of the above, the drug "Vigantol" contributes to the mineralization of bone tissue, which is extremely necessary for the normal operation of the parathyroid glands.
Pharmacokinetics of the medical device
Where does the absorption of the drug "Vigantol" occur? Instructions for use indicate that the absorption of this drug is carried out from the digestive tract. Inside the human body, the active substance comes into contact with α2-globulins, and also some part - with albumins.
Calcallyciferol is accumulated in the liver, fatty and bone tissues, as well as in skeletal muscles, kidneys, adrenals and myocardium.
The greatest concentration of the active ingredient in the tissues is observed after 4-5 hours. After that, it decreases slightly, but remains for a long time at the level required for therapy.
Specialists have found that colcalciferol is able to penetrate the placental barrier. They also found that this substance is excreted together with the mother's milk, so it is not recommended to use it during lactation.
As a result of biological transformation in the kidneys and liver, such inactive and active metabolites such as dihydroxycolecalciferol, calcipediol and calcitriol are formed.
Drug is withdrawn from the human body together with bile and in a small amount - along with urine.
For what purposes is it used?
Now you know what the properties of the drug "Wigantol".The main indications for its use are the following diseases:
Prohibitions on the use of the drug
Are there any contraindications to a medication such as "Vigantol"( the price is listed below)?It is highly not recommended to take the drug in the presence of the following conditions:
- hypersensitivity to the elements of the drug;
- presence in the kidney stones( calcareous);
How to take Wigantol? Methods and dosages of
The drug should be taken only as directed by a physician. Also, before using it, you must carefully read the attached instructions. It states that the drug "Vigantol" is given to newborns together with mother's milk or some other liquid. To do this, the solution in the right amount is mixed with food for the baby in a small spoon.
To prevent a disease such as rickets, healthy and full-term children are prescribed 1 drop of the drug every two months. Take this medicine for five days. After the specified time, make a two-day break.
Babies from one to two years are extremely not recommended to give medicines in the summer months of the year.
For preterm infants from 10 days of life, a dose equal to 2 drops( every day) is prescribed. Such treatment continues throughout the day, making two-day breaks. An exception for such therapy is also the summer months.
How to use the drug "Vigantol" to treat rickets? Drops in this case are taken in elevated doses. For example, children from 10 days of life are allowed to give 2-8 drops every day.
"Vigantol" is also prescribed for adults by the attending physician. Previously, the patient undergoes a medical examination, during which the indicator of vitamin D3 deficiency is established. By the way, its level should be controlled during the whole therapy.
What are the symptoms of an overdose when an incorrect drug such as "Vigantol" is taken? Analogues of this drug and the drug itself should be used at the dose that was prescribed by the attending physician.
Usually cases of overdose with this remedy are related to the fact that a large amount of vitamin D3 is accumulating in the human body, including a child. In this condition, hypervitaminosis A3 occurs. Its symptoms include constipation or diarrhea, pollakiuria, headache, thirst, vomiting of anorexia, nocturia, nausea, polyuria, general weakness, metal taste in the mouth and so on.
In addition to these conditions, the patient can develop more complex disorders in the form of pain in the bones, clouding of urine, increased blood pressure, skin itching, myalgia, conjunctival hyperemia, arrhythmia, etc.
With such conditions, the patients are prescribed therapy for developing hypercalcemia. The scheme of treatment of the disease depends on the degree of severity.
Thus, in the event of overdose symptoms, the drug is canceled, and the patient is prescribed a low-calcium diet, vitamin E, a large amount of liquid intake, ascorbic acid, thiamine, retinol, pantothenic acid and riboflavin.
With regard to severe cases, they require intravenous administration of 0.9% solution of sodium chloride, calcitonin, furosemide, electrolytes and hemodialysis.
In order to avoid overdose, it is necessary to constantly monitor the concentration of calcium in the blood.
In general, vitamins "Vigantol" are transferred by patients quite well. In rare cases, the patient may develop the following undesirable effects:
- calcium deposition in soft tissues;
- weight loss;
- disorders of the psyche and consciousness;
- decreased appetite, polyuria and thirst.
The drug "Vigantol" can affect the intake of other medicines. Therefore, before using it, you should always consult with your doctor and also read the instructions. By the way, the latter specifies the following features of the medicine:
- The use of "Phenytoin", as well as those related to the barbiturate group, increases the rate of biological transformation, which increases the body's need for vitamin D3.
- Combination of the drug "Vigantol" with bisphosphonates, "Calcitonin" and "Plikamycin" reduces the effectiveness of the first. It should also be noted that "Kolestypol" and "Kolestyramin" significantly reduce the absorption of the gastrointestinal fat-soluble vitamins. This fact requires an increase in their dose.
- Simultaneous administration of the drug with antacids, which contain magnesium and aluminum particles( especially for a long time), can increase their concentration in the blood, and also keep the risk of intoxication.
- It is possible to combine vitamin D3, its analogues or metabolites. However, this should be done only in special cases. It is necessary to strictly control the level of calcium in the blood.
- Complex therapy with cardiac glycosides increases the toxic potential of the drug due to hypercalcemia. Such patients need an ECG, as well as monitoring the calcium level and adjusting the dose of cardiac glycosides. The risk of hypercalcemia may increase benzodiazepine derivatives.
- A decrease in the effectiveness of the drug in question is noted with simultaneous therapy with Isoniazid and Rifampicin. This is due to the fact that they are able to increase the rate of biological transformation.
- Specialists have found that thiazide diuretics inhibit the process of excretion of calcium in urine. This effect contributes to the occurrence of hypercalcemia, which requires regular monitoring of calcium in the blood.
Price and medicines analogues
Do you know how much "Vigantol" costs? The price of this medicine can be different and depend on the pharmacy network, as well as the patient's place of residence. So what is the cost of this facility? You can buy it for 200-220 rubles.
If you could not find such a drug in your city, you can replace it with a similar one. The main analogues of the medicament in question are the following: Videchol, Aquadetrim, Vitamin D, Cholecalciferol, Kololecalciferol and others.
By comparing these medications, many people are wondering which one is better.
As is known, to prevent the development of rickets, small patients begin to prescribe medicines from their very birth that increase the vitamin D content in the blood. Most often pediatricians suggest using such drugs as "Vigantol" and "Akvadetrim."They are the most effective. However, experts recommend that parents specify the pediatricians, which means to take their baby. After all, in some cases, the patient is better to give oily, and in others - an aqueous solution.
Reviews about the drug "Vigantol"
About the drug "Wigantol" there are many different reviews. Mostly they are left by parents of young children. After all, this drug is especially often prescribed to children with a lack of vitamin D3.
Thus, through feedback, parents share their experience of using this medication, and are also interested in whether it helped other children.
According to reports of the majority, pediatricians quite often prescribe children "Wigantol".Also often used and water solution "Akvadetrim."In both cases, children experience a positive trend. As a rule, this happens after passing the full course of therapy.
According to the parents, the oily preparation is especially suitable for newborn babies. After the course of therapy, they do not reveal any abnormalities in the bone structure.
It should also be noted that, despite the high likelihood of adverse reactions, undesirable effects on the background of the "Vigantol" reception have not been recorded. By the way, there are many positive responses from patients who are pleased with the low price of this medication.