"Flutamide": instructions for use, description of the preparation, analogs and side effects

"Flutamide" is one of the antiandrogenic drugs and is used to eliminate the symptoms of androgenation. It has the ability to limit the metabolic processes of androgen hormones and effectively extends its effect to organs that need treatment. The main purpose of the drug - suppression of the male hormone, for the relief of diseases caused by its excess.

Pharmacological properties of

The drug "Flutamide-250" is used in the treatment of women and men with signs of increased production of testosterone, suffering from undesirable effects and manifestations of this hormone. Nonsteroid drugs inhibit androgen biosynthesis and glandular secretion, reduce gonadotropin production, and also reduce the concentration of active androgen molecules. The drug activates metabolic processes, increases metabolic activity to remove excess hormones from the body.

Refers to the group of non-steroid drugs and is a 5-a-reductase antagonist. The administration of "flutamide" does not affect the production of gonadotropin in the pituitary gland and does not reduce the gonadotropic function.

Indications for admission

The effectiveness of treatment brings a complex effect on the process of lowering the level of active hormones. What is the purpose of "Flutamide"?Instructions for use show a decrease, and subsequently, inhibition of the androgenation process.

Due to increased production of androgens, the activity of the enzyme 5-α-, involved in skin reproduction and promoting the sensitivity of its receptors to these hormones is enhanced. Thus, the development of idiopathic hirsutism, which needs treatment, begins.

Until recently, he was prescribed for the treatment of prostate hyperplasia in men, but not so long ago, his positive influence aimed at the successful treatment of certain female diseases was revealed. With hirsutism, alopecia "Flutamide" for women with daily intake for three months sufficiently effectively reduces the blood level of the male hormone in the blood, and these diseases lose their severity.

Diseases in which the reception of

• is indicated. Prostate cancer with spread of metastases in men.
• Hirsutism and alopecia in women.
• With surgical castration of men.
• For hormonal disorders with acne symptoms.
• When miscarriage or inability to conceive.

The main indications are symptoms that indicate an overabundance of testosterone in the body. In women, this is excessive hairiness in the male type, alopecia, menstrual irregularities, etc. There are also disorders in the metabolism of hormones with hidden symptoms, such as anovulation, hypoplasia of the uterus and mammary glands.

To make an accurate diagnosis, the attending physician prescribes an additional examination, which requires a detailed study of blood tests on the state of the level of various hormones in the body.

Self-administration of the drug, without the recommendation of a physician, can cause irreparable harm to health. Prescribing treatment should be strictly a doctor!

Features of reception

For the preparation "Flutamide" the instruction for use indicates the achievement of maximum concentration in the blood 2-3 hours after taking, which indicates the rapid absorption of the drug by the intestine. The half-life is about 5-6 hours with urine, and a little later, after 8-9 hours, the remainder is excreted. The quality of excretion directly depends on the age of the patient and the general state of health.

Diseases with symptoms of androgenization in women require an individual approach to treatment. Determination of severity, severity, localization of problem areas and other factors affects the administration of medications, usually in the reception the complex is assigned "Flutamide".Instruction for use shows the reception three times during the day for one capsule, observing equal intervals of time. The daily dose of 750 mg, the minimum duration of treatment is six weeks.

Therapy of symptoms due to increased androgen content should be combined with some other anti-androgenic drugs. Often, the complex is prescribed "Dexamethasone", "Prednisolone" and other corticosteroid drugs. Soothing procedures are also used to support the frustrated psyche of patients with obvious symptoms caused by a riot of hormones.

Even in the absence of previously worried symptoms, it is not recommended to cancel the drug on its own, this requires consultation of the endocrinologist, who is following the development of the disease. It is necessary to strictly follow all prescriptions prescribed by a doctor. If, for some reason, the tablet was missed, you should not take the next two, but just continue the usual procedure. Passage of the drug is not as harmful as a single double dose.

Form

Produced in the form of capsules or tablets, coated with a coating. Designed for oral administration. Active active substance - flutamide 250 mg.

In pharmacies "Flutamide" is sold only by prescription.

Store in a dry and cool place out of the reach of children.

Production - Orion Corporation, a pharmaceutical company( Finland).

On "Flutamide" the price is from 1798 to 1968 rubles per package( 84 tablets).

Contraindications

As practice has shown, experience in the treatment of women is not enough, mainly it concerns the uncertainty in knowledge about side effects and in harmful effects on the liver. Therefore, despite the high effectiveness, the drug should be taken with caution, following the recommendations of doctors.

• "Flutamide" is prohibited for patients with thyroid, liver or kidney diseases.
• Hypersensitivity to components of the preparation Flutamide.
• Contraindications for violations of the kidneys, liver, pancreas.
• Take with caution when prone to blood clots and with cardiovascular disorders.

Interaction with other drugs

Before using the drug, it is recommended to tell the doctor which medications are taken regularly. The doctor should take into account the intake of vitamins, food additives, up to the intake of activated carbon.

• "Flutamide" with simultaneous use with other medicines is able to enhance the action of anti-fogging agents, therefore, a correct calculation of the dosage taking into account the interaction is necessary.
• Smoking and alcohol can also alter the effect of the drug on the body. At the time of admission, it will be rational to abandon addictions.
• The doctor should also be informed about existing blood diseases.
• If you are planning a pregnancy, be sure to consult with your doctor about further admission.
• Report allergic reactions to medications, if available and known.

Overdose

If accidentally were taken in a large dosage tablets "Flutamide", then it is necessary to rinse the stomach and go to the hospital or "first aid".The consequences of an overdose can lead to an irreversible excessive increase in hormone suppression or an end to the production of gonadotropin at all, which will lead to new diseases. Therefore, it is necessary to follow the rules to take "Flutamide", the instruction for use indicates strict adherence to the dosages and instructions of the doctor.

Side effect of

After a long admission, men can detect symptoms of gynecomastia, chest pain, fluid retention.

In the event of the following phenomena, which may be simple physiological conditions, the drug should be taken with a doctor, especially if this was not the case before.

Symptoms of side effects

• Indigestion.
• Disorders of appetite.
• Lowering the libido.
• Increased mammary glands in men.
• Depressive states.
• Sleep and wakefulness disorder.
• Puffiness.
• Changes in color of urine.
• Increased fatigue.

Adverse reactions are infrequent, but with the listed symptoms it is better to notify the doctor, you may have to change something in the treatment approach or cancel the drug.

Analogues

Antiandrogens are a group of drugs that have the property of inhibiting excessive progesterone production, causing significant disturbances in a patient's health. The following non-steroid preparations can be classified by their properties and composition:

• "Cyproterone" is the most common preparation of a group of progestogens with antigonadotropic activity.
• "Spironolactone"( "Veroshpiron").The second most popular drug, replaced by "Flutamide," the principles of impact are quite similar, rather, even indistinguishable.

Before starting any drug in this group, you need to make sure that the source of the disease is not associated with pregnancy, a tumor. Careful preparation for the approach to the treatment of hyperandrogenism is required, and also contraindications and individual characteristics of each patient should be taken into account. It is important for the doctor to describe in detail the symptoms and manifestations of the disease, to name the existing chronic diseases, especially if they are associated with liver function, only so the doctor can choose conservative treatment in conjunction with Flutamide.

Reviews

Briefly tell about the feedback about the effectiveness of taking the drug Flutamide. Reviews can be discussed from those people who have been treated. In women suffering from symptoms of hirsutism, normalization of hair growth is noted. Sebaceous glands on the skin that cause acne, also restored their normal functions.

There have been cases that "Flutamide" did not really help, the reviews did not confirm the special benefit of the reception, this is most likely due to incorrect diagnostics or inaccuracies in the application. Some patients do not take a long course of treatment to the end because of the price of the drug, in which case it is possible to consult a doctor and resort to cheaper analogues so as not to discontinue therapy. On "Flutamide" the price is quite high, and it is necessary to take this into account, the treatment course is quite long and will require some financial waste.

Special instructions

For complex treatment three days before the application of the agonist GnRH should be taken "Flutamide" to reduce the likelihood of side effects. With liver failure, treatment is indicated only if it is the only method that solves the problem. A laboratory study of liver function should be performed. There was a slight increase in the liver with the reception of "Flutamide", but after the withdrawal the size became normal. If undesirable symptoms are recommended, discontinue the drug.

Appropriate laboratory tests to assess liver function should be performed every patient once a month for the first 4 months, and then periodically or with the development of the first symptoms of impaired hepatic function( itching, darkening of urine, persistent loss of appetite, jaundice, tension in the right hypochondrium).For long-treated men in the absence of chemical or surgical castration, regular testing of sperm is required to preserve the childbearing function.

For the driving of the vehicle and the management of the research mechanisms was not carried out. But if there are such symptoms as dizziness or headache, it is better not to risk and do not sit behind the wheel.