"Clozapine": instructions for use, analogues, price

Brain trauma, stress, anxiety, alcohol abuse, drug addiction, genetic predisposition - all these factors can cause schizophrenia and other mental disorders. To correct the situation and cure a person of such serious problems, Clozapine will help. This antipsychotic agent, which should only be used under the supervision and supervision of a doctor. Today we learn all about this medicine: the form of its release, the rules of use, analogues, cost. clozapine instructions for use

When can it be useful?

The preparation "Clozapine", the instruction for use of which is placed in the insert, can be prescribed by the doctor for the following problems:

- schizophrenia at any stage;

- psychosis;

- sleep disorders;

- depression;

- psychomotor agitation;

- emotional and behavioral disorder.

Ingredients, formulation, country of manufacture

The main component of the drug is clozapine.

The preparation is issued in the form:

- tablets of 25, 50, 100 mg, the package can contain 10, 50 or 100 pills;

- granules for children( in bags of 500 mg);

- solution for injection( in ampoules of 2 ml).

Produced medicine in India, Russia, Germany. clozapine price

Instructions for the use of tablets

The dosage of the preparation "Clozapine" is set individually. Usually the daily norm is from 200 to 400 g. For the first time the doctor appoints 25-50 mg, gradually for 1 or 2 weeks, bringing to the desired dose.

After the main course of therapy, the doctor may prescribe supportive treatment, in which it will be necessary to take from 25 to 200 mg of the drug.

In small daily doses, the Clozapine drug, the instructions for its use must always be in the package, is taken with:

- renal, hepatic or heart failure;

- cerebrovascular disorders;

- problems with sleep.

The daily dose should not be more than 600 mg.

Instruction for the use of solution and granules

The drug "Clozapine" can be used for injections. The drug is administered intravenously by a nurse 2 ml each.

For children this medication is prescribed as a solution. For this, it is necessary to pour the granules from the packet into a glass, pour in 10 ml of water, mix well. For 1 reception you can drink from 5 to 20 mg of the drug, depending on the age of the child. However, the maximum daily allowance for children should not be more than 100 mg of Clozapine solution. A prescription from a doctor is a prerequisite when buying this medication in any form of release. Without it, the pharmacist will not sell the medicine.


Tablets "Clozapine" is prohibited to use:

- with strong susceptibility to the components of the drug;

- during epilepsy;

- with vascular insufficiency;

- during intestinal obstruction;

- with hepatic, renal insufficiency;

- if the patient can not regularly take a blood test;

- during alcoholic psychosis, drug intoxication;

- with granulocytopenia, agranulocytosis;

- in comatose conditions;

- for women who are under the heart of children, and also during lactation:

- for boys and girls under 5 years. clozapine analogues

Adverse Effects

The drug "Clozapine", the instructions for its use, which many will find incomprehensible, must be taken with caution. Side effects after treatment with this drug may be different, for example:

- tachycardia, arterial hypertension, respiratory arrest.

- nausea, vomiting, heartburn, abdominal pain;

- weight gain;

- drowsiness, dizziness, fatigue, tremor.

- dry mouth, constipation, increased sweating, trouble urinating.

- skin rash, dermatitis, pigmentation, urticaria.

Overdose of

The agent "Clozapine", analogues of which will be considered below, should be taken strictly according to the doctor's prescription. Otherwise, unpleasant and even dangerous symptoms of overdose can arise:

- confusion;

- drowsiness;

is a delusional state;

- convulsions;

- coma;

- problems with eyesight;

- tachycardia;

- respiratory depression;

- collapse.

If a person took a large amount of money, then he must help. Treatment for an overdose will be as follows:

1. Rinse the stomach.

2. Drink activated charcoal.

3. Seek medical attention. clozapine preparations


The drug "Klozapin", the price of which differs depending on the form of release of the drug, the dosage of tablets and solution, the location of the pharmacy, is currently difficult to acquire. Analogues of this tool are slowly being replaced. After all, they put a decent price, while the drug "Clozapine" is cheaper. So, for 50 tablets you need to give about 200 rubles. If you take pellets for children, they will cost 1000 rubles.

Communication with other medications

Many people do not know that it is very cautious to take the drug "Clozapine".Drugs that can be used in parallel with this drug, but under the doctor's close attention:

- tablets, suppressing the central nervous system, - the fact is that if the patient receives such funds in parallel, the respiratory center may be depressed;

- drugs containing in the composition of ethanol;

- drugs that lower blood pressure;

- tablets that cause myelodepression, parallel reception of such drugs can inhibit bone marrow hematopoiesis;

Also with extreme caution, you need to use the drug "Clozapine" with caffeine because of the possible increase in side effects. azaleptin clozapine


The drug "Clozapine" has analogues, and there are a lot of them. The most popular substitutes are such drugs: Genodin, Kvetiksol, Quetiron, Nantarid, Zalasta, Ziprexa Zidis, Parnasan, Egolansa. Analogues have exactly the same effect as the drugs "Clozapine", but the active substances they have other.

Preparation "Kveteksol"

This medication is also intended for the treatment of schizophrenia, as well as manic conditions.

The medicine is in the form of tablets. The main active substance of this drug is quetiapine.

The medicine is applied only to adults. Usually the daily dose for the first 4 days is not more than 300 mg. Further the doctor can increase a dosage of this medicine to 450 mg a day.

The cost of tablets "Kviteksol" of 25 mg( 30 pills) will cost a man of 200 rubles. If you buy tablets in a larger dosage - 100 mg in the same amount, then you have to pay about 750 rubles.

Preparation Ziprexa Zidis

This medication can compete well with the medicine in question. Ziprex Zidis is available in the form of tablets, where olanzaline acts as the active ingredient.

Pills are used in such cases:

- treatment of exacerbations of schizophrenia;

- therapy of acute manic conditions;

- treatment of depression.

The daily dose of the drug is determined individually, depending on the diagnosis of the patient.

For the treatment of schizophrenia, the doctor initially prescribes 10 mg of medication once a day.

For the treatment of acute mania, the recommended initial dose is 15 mg 1 time per day.

But these are all conditional values. For a specific regimen for the therapy of the aforementioned ailments, you should consult your doctor.

The medicine "Ziprex Zidis" is released on prescription.

The cost of 7 tablets is about 2500 rubles. This is very expensive, given that the pills in the package are enough for only a week. And for 28 tablets you need to give about 9 thousand rubles.

Produced in the UK.clozapine prescription

What is the Register of Medicines?

This is a documentation system that contains full information about medical products. This includes: a registration certificate, instructions for use, an order for the production of a medicine, etc. All new drugs, including the "Klozapin" medication, are included in this register of medicines. This list allows you to officially use this or that tool.

As for the drug "Klozapin", it is produced under several trade names, and in the register they are all prescribed, for example:

- Medication of Ukrainian production "Azalepro".

- Swiss drug "Leponeks."

- Russian tablets "Klozasten" and "Azaleptin".

Each of these medicines has its state registration number, the end date and the registration renewal.

The name of the drug "Clozapine", the synonyms of which were listed just that, is international. And already medicines such as Azaleprol, Leponex, Klozasten and Azaleptin are considered to be its derivatives. They are developed and implemented in a specific country.

The drug "Azaleptin"

This is also an antipsychotic drug, a neuroleptic, prescribed for schizophrenia, manic states, psychoses, psychomotor agitation, emotional disorders in children, etc.

A drug is produced in the Russian Federation.

The form of the product "Azaleptin" is the only one, and it is a tablet of 25 and 100 mg. The active substance of the drug is clozapine.

About 420 rubles should be given for 50 tablets of 25 mg of the drug "Azaleptin"."Klozapin" - a medicine to which the article is devoted, costs two times cheaper.

Swiss drug "Leponex"

This is another synonym for the drug under consideration, which is prescribed for the same health problems. The medicine "Leponeks" is produced in two forms:

  1. Tablets.
  2. Solution for injection.

medicines registry

The active substance of this drug is the same clozapine. One Leponex tablet can contain 25 or 100 mg of the main component. And additional elements are: magnesium stearate, anhydrous silica gel, talc, corn starch, polyvinylpyrolidone, lactose.

At the initial stage of treatment on the first day, 1 tablet( 25 mg) is prescribed 1 or 2 times a day. On the second day - 2 pills. In the future, the doctor can gradually increase the dose to a maximum of 300 mg.

The drug "Leponex" also has the same side problems, limitations in the application as the drug in question.

The cost of these tablets of 25 mg in the amount of 50 pieces is 1200 rubles. And for 100 pills of 100 mg will need to give 5400 rubles. This is much more expensive than the means of "Klozapin", the price of which will be affordable for any person. It turns out that the medicine "Leponeks" for some categories of the population( low-income people) will be inaccessible.


From this article you learned a lot of interesting and useful information about the drug "Clozapine".Instructions for use, contraindications, side effects, cost have been described. We realized that this medicine has many analogues that can compete with it. True, the cost of these drugs is higher. However, in pharmacies, these analogues have long ago supplanted the drug "Clozapine".But if you are lucky enough to find it, then you will save a lot.