Instructions for the use of Zolpidem. Reviews and Analogues
What is a Zolpidem medication? Instructions for use, synonyms and indications of this medication will be discussed further.
Form and composition of
What does Zolpidem contain? The instruction states that the medicament in question consists of an active substance such as hemitortrate zolpidem( 10 mg), as well as auxiliary elements. It is available in the form of white tablets, which are placed in the cell outline packaging of 15 pieces.
Pharmacological features of
How does the drug work? What does the instruction for use say?"Zolpidem" is very close to benzodiazepines by its action principle. This medication is able to show hypnotics, anticonvulsant, amnestic, anxiolytic and sedative properties.
The active element of the drug has a direct effect on the benzodiazepine receptors of the second and the first types. It promotes the discovery of anionic neuronal channels with the help of GABA receptors, which subsequently leads to an increased current of chlorine.
Interaction of this drug occurs selectively. In this regard, the effect of taking the drug depends on the dose taken. Thus, smaller dosages allow achieving amnestic, muscle relaxant and anxiolytic properties and avoiding the hypnotic effect of
. What is remarkable about this medication? What does the instruction for use say?"Zolpidem" accelerates the process of falling asleep and improves the quality of sleep. It should also be noted that after awakening, drowsiness in the patient does not persist.
How does the absorption of Zolpidem medication occur? The use of this drug, or rather its dosage depends on the indications. After about 30-110 minutes, the active substance of the drug reaches its maximum level in the blood. Almost everything is associated with plasma proteins, and its bioavailability is 70%.
After admission to the liver tissue, the drug undergoes metabolic reactions, resulting in the formation of inactive derivatives. Some of them are excreted together with urine and approximately 40% - together with feces.
The half-life of the drug is 150 minutes. With serious violations in the liver, this process is extended to 10 hours.
Preparation Zolpidem, instructions for use, the photo of which is presented below, penetrates into the mother's milk.
What is it used for?
What are the indications for this drug? What does the instruction for use say?"Zolpidem" - a pill designed to normalize sleep. They are used for night awakenings, insomnia or early ascent.
Prohibitions to use
Like all medicines, the Zolpidem medication, the instruction of which is contained in a pack of cardboard, has its contraindications for use. The drug is not prescribed for:
- allergies to zolpidem or other benzodiazepines;
- respiratory failure severe or acute;
- nighttime apnea;
- severe liver or kidney disease;
- of lactation;
- at a minor age.
It should also be noted that people who are depressed, as well as alcoholics, drug addicts and other addicts, should be especially careful when taking this medication. Otherwise, this can aggravate the patient's difficult situation.
Instructions for use
"Zolpidem" in tablet form should be taken only before bedtime. The standard dosage of this drug is 10 mg per day. For the elderly, the initial dose of the drug can be equal to 5 mg. If you need it, you can double it.
The maximum daily amount of Zolpidem is 10 mg. The duration of its application should not exceed more than one month.
For people with transient insomnia, doctors recommend using the drug for 2-5 days, and for a situational one - 14-21 days.
In the event that the treatment with Zolpidem continues for several days, the medication can be stopped abruptly. If the therapy is more than one week, then reduce the dose should be gradual, in order to avoid the development of unwanted reactions.
Side effects of
How is the Zolpidem medication tolerated by patients? Instructions for use, reviews argue that in most cases the drug in question does not cause negative reactions. However, there are situations when against the background of using this medication the patient nevertheless feels the following undesirable effects:
- nausea, drowsiness, vomiting, headache, diarrhea;
- insomnia is a paradoxical, painful sensation in the stomach, excitement;
- dizziness, nightmarish dreams, anterograde amnesia( the risk of developing the latter is directly proportional to the accepted dosage).
It should also be noted that very rarely Zolpidem causes the following reactions:
- irritability, confusion, dysphoria, aggression;
- unusual behavioral reactions, somnambulism, drug dependence;
- skin rash, liver function problems, hyperhidrosis, elevation of hepatic enzymes, Quincke's edema;
- weakness in muscles, itching, decreased sexual activity, hives;
- ataxia, diplopia.
Cases of overdose
What symptoms of overdose can cause a drug "Zolpidem"?Instruction for use informs that if you abuse the medicine in question or if you accidentally swallow a lot of tablets, the patient may have confusion, ataxia, difficulty breathing, lowering blood pressure, coma and blocking.
In case of an overdose, the patient should be vomited as soon as possible( within an hour).Also, the affected person should be given enterosorbents.
If the patient is unconscious, the stomach is washed with a probe, and symptomatic therapy is performed.
Interaction with other
agents Is it acceptable to take Zolpidem with other medications? Instructions for use( a prescription for the purchase of this medication should be prescribed only by an experienced physician) states that a remedy such as "ketoconazole" can almost double the half-life of the drug. In addition, this medication can enhance the effect of CNS depression.
Parallel administration of the drug with alcohol often leads to a pronounced sedative effect of the drug, as well as its overdose.
The drug "Rifampicin" significantly speeds up metabolism, reduces the effectiveness and concentration of the taken tablets.
With which medications should you use Zolpidem medication with extreme caution? Instructions for use( analogues are listed below) reports that the effect of therapy may be negative if the drug in question is combined with:
- anxiolytics, barbiturates, antiepileptic drugs and narcotic analgesics;
- hypnotics, antipsychotics, central antitussives and antidepressants;
- with antihistamines with sedative effect, preparations for general anesthesia;
- "Pisotifen", "Baclofen" and "Thalidomide".
It should also be noted that when combining this medication with "Buprenorphine", the risk of developing respiratory depression is significantly increased.
The preparation "Zolpidem" with "Intraconazole" can be combined, but with extreme caution, since in this case it is possible to change the pharmacodynamic and pharmacokinetic parameters of the first agent.
What do you need to know about Zolpidem? Instructions for use( in tablets this drug is sold in almost all pharmacies), states that with prolonged treatment( approximately 20-30 days), the patient may develop a mental or physical dependence on the drug. Such a reaction is especially affected by those who previously had a dependence on alcoholic beverages and other substances. In this regard, such a group of patients should be kept under constant control, and periodically monitor their mental and physical condition.
It should be specially noted that the risk of dependence is significantly increased if the agent in question is combined with other benzodiazepines.
When taking Zolpidem, the patient should be aware that within 8 hours after taking the pill, he should be in a comfortable sleeping environment, otherwise he may develop anterograde amnesia.
If, after a few weeks of treatment, insomnia has not passed, the patient needs to reassess the condition. Most likely, such a paradoxical reaction is a consequence of primary mental disorders.
In the process of treatment, the person under consideration should refrain from performing actions that require increased concentration of attention, as well as driving the car.
Some people may develop unusual behavioral disorders and mental reactions when taking Zolpidem( especially in the elderly).In this case, you should immediately stop taking the drug.
In the presence of liver disease, the active substance of the drug can accumulate in the body, and subsequently lead to undesirable effects.
With extreme caution, this medication should be administered to the elderly. This is due to the fact that they have a high risk of developing a sedative and miorelaxing effect, which can lead to falls and injuries.
Shelf life, terms of sale, storage
Due to the fact that the drug in question causes dependence, you need to have a prescription for its purchase. Store this medicine preferably in a place that is well protected from children, at a temperature of not more than 25 degrees. Shelf life of the drug is three years.
Similar remedies and synonyms for
The most common insomnia drugs that are similar to Zolpidem are the Andante, Donormil, Sondox, Barbovan, Zopiclone, Sonmil, Imovan.
As for the synonyms, they include: "Hypnogen", "Ivadal", "Zolsana", "Oniria", "Snovitel", "Sanval", "Nitrest."
Lactation and pregnancy period
The effect of the drug in question on pregnant women has not been studied. However, the results of studies that have been conducted on laboratory rats, argue that this medication has a teratogenic effect. In connection with this, taking Zolpidem medication during fetal gestation is highly discouraged.
One can not help saying that a hypnotic in a small amount can penetrate into the mother's milk. Therefore, lactation at the time of treatment should be discontinued.
Comments of consumers and the cost of the preparation
You can buy the medicine "Zolpidem" in almost any pharmacy, presenting a prescription to the pharmacist. The average cost of this medication( 10 tablets) is about 820-900 rubles. Patients argue that this is a fairly high price for a hypnotic. However, experts say that the cost of this drug is justified, as it is good for insomnia and bad sleep. Most consumers fully agree with the latest statement. They respond well about the drug, but only if they take it strictly according to the doctor's prescription or instruction.
In their reports, patients say that the drug in question allows them to fall asleep normally and quickly, and also to get a good night's sleep after the stress. However, Zolpidem tablets also have negative sides. For example, they can cause side reactions, which most often develop with hypersensitivity to the active substance of the drug or non-compliance with the regimen. The most common negative effects are: headaches, dizziness, nausea and hallucinations. In this case, the patient may develop habituation, especially when the drug is combined with alcoholic beverages.