"Hydrea": instructions for use, reviews, photos, analogies
Medicinal drug "Hydrea" belongs to antitumor drugs. The drug has a cytostatic effect, the mechanism of which is based on the inhibition of DNA synthesis, while the effect on the synthesis of RNA and protein is absent.
In what form is the preparation made, of what does it consist?
The medication is available in the form of capsules, it is made on the basis of hydroxycarbamide, which in each capsule is 500 mg each. The drug can be purchased in a glass bottle( 100 capsules) or blister( 10 capsules).Of the auxiliary components, magnesium stearate and citric acid are used. Also, the composition is supplemented with sodium hydrogen phosphate and lactose monohydrate.
For the substances that make up the capsule shell "Hydrea", the instruction refers titanium dioxide, dyes and gelatin. The inscription is formed by ink, which is obtained due to the combination of propylene glycol, shellac, alcohol( isopropyl, methylated industrial and N-butyl), as well as purified water and iron oxide of black color.
The drug is an antimetabolite, its effect is manifested in the S phase of the cell cycle."Hydrea" allows to stop the development of cells in the interphase G1-S, which is very important when radiotherapy is performed simultaneously with the taking of this medicine, since in the G1 phase the tumor cells become sensitive to irradiation. The drug enhances the effect of ribonucleoside diphosphate reductase( an inhibitor of RNA reductase).Due to its use, the process of DNA synthesis is inhibited, but protein and RNA formation is not disturbed.
Absorption in the gastrointestinal tract of Hydrea medication describes the instructions for use as a fast, unaffected food intake and leading to the maximum level of active substance in the body approximately two hours after the internal use of the drug. The medication passes through the blood-brain barrier, is characterized by a rapid distribution, is present in ascites and cerebrospinal fluid. The medicine accumulates in erythrocytes and leukocytes, partially excreted from the body within three to four hours. Partial metabolism is carried out in the liver. Most of the drug is excreted by the kidneys in the form of hydroxyurea, an approximate length of this process is twelve hours. Its some part does not change its appearance, a small amount of the drug is removed from the body with urine. Through the respiratory tract, the drug is excreted as carbon dioxide. After the reception of Hydrea, the instruction informs of its complete elimination within 24 hours. Since the bulk of the drug passes through the kidneys, patients who have pathologies of these organs reduce the dose of the drug.
"Hydrea" instructions for use allows you to prescribe for such conditions of the body:
- myeloid leukemia;
- cancer, in the development of which the cervix, lungs, prostate gland, colon or ovaries are affected( therapy should be combined);
- the presence of malignant neoplasms in the neck and head, exceptions are only cancer that affects the lips( there is a need for comprehensive treatment);
- is an essential platelet thrombocythemia;
- chorionepithelioma of the uterus;
- acute lymphoblastic leukemia;
- thrombocytosis as a complication of myeloproliferative syndrome;
- appearance of metastases in cancer that affects the mammary glands and stomach.
There are cases in which treatment with Hydrea is unacceptable. Drug instruction prohibits the appointment in such cases:
- high sensitivity to the components of capsules;
- thrombocytopenia and leukopenia at rates less than 100,000 and 2500 / μL, respectively;
- pregnancy, feeding the baby with breast milk.
Although in the following cases the drug is not contraindicated, special caution is necessary in its administration and use:
- glucose-galactose malabsorption;
- lactose intolerance;
- deficiency of lactase;
- Severely leaking anemia;
- failure of renal and hepatic failure.
If a patient has previously undergone chemotherapy or radiotherapy, there is a risk of exacerbation of radiation erythrema and the development of myelosuppression, so in this case, too, you must carefully apply the medication.
During the period of therapy, reliable contraception is needed, if pregnancy does occur, the patient should be aware of the risk that exists for the fetus. Due to the penetration of the medicament into the composition of breast milk to women who breastfeed, it is necessary to stop this kind of feeding. If the drug is scheduled to be canceled, the specialist should take into account all sorts of points before he allows the patient to refuse treatment based on taking Hydrea capsules.
During the period of treatment with Hydrea medication, the instructions for use recommend using different doses of the drug in different conditions, taking into account the characteristics of the patient's body.
If it is difficult for a patient to swallow a capsule, it can be opened to dissolve the drug in water. In such cases, drink the drug right away. It should be borne in mind that not all the components of the capsules dissolve in the water, remaining on its surface. Patients who are treated with Hydrea should drink plenty of fluids.
Myeloleukemia( chronic form)
Treatment is performed without interruption. For each kilogram of weight takes 20-30 mg of the drug. This is the daily norm, every day the drug is drunk once. The possibility to evaluate the effectiveness of therapy is already present after 1.5 months of it. If positive results are noted, the treatment can be quite long( if necessary), when the platelet count and white blood cells fall below the norm, it is stopped. If the blood composition is normalized in three days( not earlier), it is possible to resume therapy with Hydrea. Instruction for use shows that this possibility appears quickly.
The dose required for daily administration is 15-20 mg. As in the previous case, this amount of the drug is calculated for one kilogram of weight. In a day, the patient is usually prescribed 1 or 2 capsules. The final dose for each patient is determined by its weight, depends on the amount of platelet and hematocrit at normal levels.
The initial dose per kilogram of weight corresponds to 15 mg. The daily dose is selected individually so that the important indicators are at the desired level. If the instruction is prohibited by the Hydrea drug, the synonyms are considered by the doctor and the most appropriate remedy is selected.
In tumors of large sizes, treatment can be either intermittent or continuous, respectively, the necessary dose of a drug per kilogram of weight is 80 or 20-30 mg. With continuous therapy lasting three weeks, the medicine is drunk daily one time. If the therapy is performed with interruptions for three days, it is also drunk once, but in a larger dose.
Carcinoma( lesion of the cervix, head or neck)
For each kilogram of weight, 80 mg are taken. The necessary dose of the medicine is drunk every three days( once).
When using the Hydrea drug, the instruction, the reviews report some side effects from the hematopoiesis system, nervous, urinary, respiratory and digestive systems. Also, the skin and their appendages can be affected, possibly the development of such an infectious process as gangrene. There may be other negative reactions of the body.
The price of the preparation, analogues
You can buy the packaging of Hydrea for 243-250 rub.(20 capsules).Among the substitutes are preparations that contain the same active ingredient as Hydrea, and drugs that have a similar effect.
From synonyms you can buy "Hydroxyurea" or "Hydroxycarbamide medak".When the instruction is forbidden by Hydrea, analogs can be chosen from a large number of medications, for example, from Tromboreductum, Amilan FS, Colotecan, Milanfor, Prospidina, Iritena, Halavena, Estracitum, "Irinotela", "Camptothecan" or "Estracite".You can buy such substitutes as "Agrilin", "Kampeter" or "Erivage".Among the means of a similar action are "Aranoza", "Irinaks", "Arglabin".A list of similar drugs is made up of "Zaltrap", "Irnokam", "Hexalen".You can be treated with "Proxifein", "Gikamtin", "Kampto", "Verotecan", "Chloditan", "Prospidin", "Oncophagus", "Irinotecan" or "Velcade."
Many patients believe that before the start of therapy, the description of the Hydrea tool, the instruction, should be studied. Photos before and after therapy can also be viewed. Judging by the reviews, people prefer to be treated only under medical supervision and do not risk self-treatment, as it is dangerous, they drink a lot of fluids. If the medication is not combined with radiotherapy, side effects either appear( in cases when previously absent), or become even more pronounced. But this does not always happen.