Preparation "Pregnil": reviews, instruction

Many women today suffer from infertility. Thanks to modern medical products, you can solve the problem and feel the joy of motherhood. One of the popular and proven drugs can be called "Pregnil".Almost all happy patients leave their comments.

Formulation and composition of the preparation

This is a recombinant human chorionic gonadotropin. The drug is administered subcutaneously and intramuscularly. The drug's leofilisate is white. To him in the kit is a bottle of solvent. It is clear and colorless. The main substance of the medicine "Pregnil" is the human chorionic gonadotropin. Auxiliary components are magnesium hydrophosphate, carmelose sodium, mannitol, sodium digitrophosphate.

The solvent contains an isotonic sodium chloride solution. Produced in a dosage of 2 ml. In the box there are three ampoules of dry substance and the same number of ampoules for dissolution of the drug "Pregnil".Reviews show that achieving the desired pregnancy is obtained in 60% of cases after the passage of therapy.

Pharmacological action

The medicine "Pregnil" contains human chorionic gonadotropin. It has a high degree of similarity with the action of luteinizing hormone. This substance is indispensable for the normal growth and maturation of male and female gametes. LH is also needed to create sex hormones. It is equally useful to both women and representatives of the stronger sex. To representatives of the weaker sex, the drug "Pregnil" replaces the formation in the middle of the cycle of endogenous luteinizing hormone to help complete the phase of the formation of follicles that are responsible for ovulation.

The medication is also prescribed as a substitute for endogenous LH in the luteal phase. It is not accidental that the positive preparation "Pregnil" often has reviews. Who became pregnant immediately after the treatment, he tries to recommend the drug to others.

For men, the medicine "Pregnil" stimulates the production of leidig cells. Thanks to timely treatment, it is possible to normalize the level of testosterone in the blood from the stronger sex.

Pharmacokinetics of drug

The highest peak in blood chorionic gonadotropin after injection reaches eight hours in men and 20 hours in women. There is a big difference between the absorption of the substance after the injection in different sexes. In women, the rate of hormone concentration in the body is delayed. This reaction is most related to the increased thickness of adipose tissue in the body.

Almost 80% of the drug is broken down in the kidneys. After one injection, the substance is withdrawn after 33 hours. So the "Pregnil" medicine works in the female and male bodies. Instruction, reviews, correct dosage - all this information should be studied before the start of therapy.

Dosage

After diluting the dry substance with a solvent, it is necessary to inject the injection intramuscularly or subcutaneously. For the creation of ovulation in infertility in the absence of it or disturbance of maturation of the follicles, a woman is administered from 5000 to 10 000 IU of the drug "Pregnil".

Has a positive tool "Pregnil 5000" reviews. Who became pregnant, he tries to share important information with women who have not yet experienced the joy of motherhood. However, self-medication on the recommendation of friends to deal with is undesirable. The drug should appoint a specialist.

To complete the treatment with follicle-stimulating agents, it will be enough to make one injection of "Pregnil".The doctors' comments show that the therapeutic effect occurs within a month. The drug is administered before ovarian puncture while passing the hyperstimulation control program. To maintain the phase of formation of the yellow body, it is necessary to inject in a dosage of 1000 to 3000 IU.The injections are made on the third, sixth and ninth day of artificially induced ovulation.

Men with a low testosterone content in the body are injected at a dose of 1000 to 2000 IU twice a week. With the development of infertility, you need to add to the preparation "Pregnil" additional medications. For example, the substance "Phyllithropine".It must also be stabbed twice a week. The course can last up to 3 months. In this case, it is necessary to expect an increase in spermatogenesis. When treatment with the drug "Pregnil" you need to give up substitution therapy with testosterone.

Dosage of the drug in childhood

In boys with a delay in puberty, "Pregnil" is administered at a dose of 1500 IU twice a week for six months. In children under 2 years of age, the drug is administered at a dosage of 250 IU twice a week for 6 weeks. Up to 6 years, the dosage is 500-1000 IU.The course of the decay can be quite long. After 6 years, the dose of the drug reaches 1500 IU.

In case of insufficient therapeutic effect, treatment is recommended to be repeated.

Side effects of

In very rare cases, a generalized rash or fever may occur. There is also a local reaction at the injection site. It is manifested by swelling, tenderness and itching. Women do not often develop thromboembolism after passing the course with the drug "Pregnil 5000".The reviews show that the side effects are temporary and pass quickly.

In rare cases, the syndrome of ovarian hyperstimulation develops. There is hydrothorax, abdominal pain, diarrhea, nausea, tenderness of the mammary glands, a small increase in the ovaries and cysts. An increase in body weight is another unpleasant symptom.

In men and adolescents, in the treatment of large doses of the preparation "Pregnil", water and sodium can be delayed in the body. This occurs as a result of an excess of adrogen. There may be an increase in the mammary glands.

As it is possible to understand, the "Pregnil" preparation has many side effects. Feedback from experts show that the presented symptoms are not dangerous to health. However, they should be reported to the attending physician.

Contraindications to treatment with

Some patients may develop an increased sensitivity to the main substance of the drug "Pregnil"( gonadotropin) and its auxiliary components. Do not prescribe a remedy for suspected or having tumors in women of different etiologies.

In children with early puberty, the medication is not used. Women with an incorrect location and development of organs that are incompatible with pregnancy, also the drug is contraindicated. With caution, you need to prescribe a medicine with the propensity of the body to thrombosis. The agent is not used for cardiac and renal insufficiency. All these contraindications should be considered before starting therapy with the drug "Pregnil".The feedback from specialists shows that the positive effect will be only if the patient passes a complete examination of the body beforehand.

Reviews about the drug

The drug gives an excellent effect in the violation of ovarian maturation, the absence of ovulation in infertility. In men and adolescents, with a small amount of testosterone, the medicine also brings an excellent therapeutic result.

Negative reviews of the medication are also available. They are most often associated with the wrong drug intake.

Usually the agent is used to treat infertility in women. You can hear more often good about the preparation "Pregnil 5000" reviews. Who became pregnant, he knows how important is timely therapy.