"Buspiron": reviews, instructions for use, analogues
Buspirone refers to drugs that affect the nervous system. This is an anxiolytic, designed to eliminate anxiety and fear, normalize sleep, improve health in the presence of neurosis. Tablets "Buspiron" have some contraindications and are capable of causing side effects.
Composition and form of the preparation "Buspirone"
The drug is available in the form of tablets with a dosage of 5, 10 and 20 mg. The active substance of the drug is buspirone. The auxiliary substances include potassium hydroxide, corn starch, magnesium stearate.
The action of medication is sedative, anxiolytic. The medicine removes the symptoms of fear of a vegetative and mental nature. The mechanism of action of the agent is not completely established, but it is known that Buspirone differs from benzodiazepines and other anxiolytic drugs.
Strong inhibitory effect on the central nervous system is absent after taking "Buspirone" tablets. The instructions for use show that the drug reduces the formation of serotonin and its release, slows down serotonergic processes, promotes the blocking of D2-dopamine receptors( postsynaptic and presynaptic endings), accelerates the excitation of dopamine neurons located in the middle brain. After the withdrawal of the drug, there are no symptoms of withdrawal and the return of an alarm.
The drug is intended for oral use. Penetrating into the body, for a short period of time, it is completely absorbed into the digestive tract. As a result of intensive metabolism, bioavailability is only 4%.The maximum level of the drug is reached in the blood about an hour after penetration into the digestive tract. Half-life is carried out for 2-3 hours, binding to plasma proteins corresponds to 95%.Continuous use of Buspirone does not affect its effectiveness.
During treatment it is not necessary to immediately expect the appearance of the effect of "Buspirone".The instructions for use show that the effectiveness of the drug is evident from the 7th to the 14th day of its administration. The maximum effect of the drug manifests itself after about 120 days of treatment.
Indications for use of Buspirone
Specialists prescribe medication for sensations of danger, detection of fear and anxiety, unmotivated irritability, mild neuroses and sleep disorders, which are of a systematic nature. The drug is suitable for the treatment of somatic disorders, autonomic dystonia and depression, elimination of tension, alcohol withdrawal.
Contraindications to the use of the drug Buspirone
Buspirone( analogues of the drug in particular) has contraindications. The original drug is not allowed in such cases:
- glaucoma( closed type);
- severe pathological processes in the liver and kidneys;
- cardiac dysfunction, vascular problems;
- of the respiratory tract;
- myasthenia gravis;
- Hypersensitivity to components;
- period of bearing a child, feeding him with a breast;
- age is less than 18 years.
If there is a history of seizures or epilepsy, it is strictly forbidden to prescribe the patient a tablet of "Buspiron".
Before starting therapy, the patient should be tested for susceptibility to the drug.
Application of the drug, dosage of
During the treatment with Buspirone, the use of tablets is carried out in accordance with the recommendations of the attending physician. The official instruction contains information that for each patient a different dose of the drug is needed, since the individual treatment regimen determines the effectiveness of the performed therapy. The dosage depends on the patient's state of health. General recommendations are as follows:
- initial stage - 3 admission of 5 mg of medication;
- continued therapy - a gradual increase in dose with an interval of 2-3 days( if there is such a need);
- administration of a maximum daily dose of 50 mg( in the absence of the desired effect).
Tablets "Buspiron" instructions for use allow to take only in a general form, they can not be dissolved in liquid, grind and chew. The medicine is washed down with an abundant amount of water, taken at any time of the day, regardless of the meal. The recommended course duration is 4 months. Longer than this time, it is not recommended to be treated with Buspirone.
Side effects of Buspirone
Some undesirable reactions of the body can be detected with the drug. For example, drowsiness, general deterioration of health, weakness, fatigue, apathy. If such effects occur, it is necessary to cancel the drug. It is worth to consult a doctor and inform him about negative changes in the body after taking the tablets "Buspiron".Instructions for use in such cases recommend reducing the dose of the drug. If the side effects do not disappear, the doctor should replace the drug with another, more suitable medication.
In very rare cases, the use of Buspirone causes abnormalities in the digestive system. For example, heartburn and nausea may occur, followed by vomiting. There may be pain in the epigastric region. There may be other side effects. All these manifestations indicate the intolerance of the components of the drug.
Overdose of Buspiron
If the drug is used in doses higher than recommended, a person may have symptoms of an overdose. These include nausea with vomiting, gastrointestinal disorders of a different type. The patient is dizzy, the pupils contract, and a brief loss of consciousness is possible. Patients who left feedback after treatment with Buspiron Sandoz, note the possibility of confusion, tremor of the upper limbs. Among other manifestations of overdose - irritability, increased excitability, frequent changes in mood. Overdosage is treated by washing the stomach, introducing activated carbon into the body, performing symptomatic therapy and maintaining a constant control of blood pressure, heart rate, respiratory activity. There is no specific antidote for overcoming the symptoms of an overdose with Buspirone. Dialysis in such situations does not bring the desired effect.
Interaction with various substances and other medicines
Sometimes, with the prohibited combination of certain preparations with Buspirone tablets, the instruction on the use of analogs is recommended as a substitute for the original remedy. It is known that medication can not be taken simultaneously with tranquilizers, sedatives because of the increased effect of the drugs taken. When treating "Buspirone" you should exclude the use of alcoholic beverages. It is impossible to combine the intake of drugs with the use of MAO inhibitors because of the risk of hypertensive crisis.
With the simultaneous use of "haloperidol" with "buspirone" in the blood, the level of this drug increases. Combination of the drug with Trazodone leads to a significant increase in ALT.
As a result of experiments involving animals, there was no adverse effect on the body during the period of therapy. However, in order to avoid unwanted reactions of the body from its use, it is worth noting.
"Buspirone" instructions for use as a means, the metabolism of which is carried out in the liver. In this process, CYP3A4 is involved, which is an isoenzyme that facilitates the processing of the drug by the body. For this reason, Buspirone can interact with drugs that refer to inducers or inhibitors of the enzyme.
Features of the use of the drug
If lactation requires the use of therapy with Buspirone, breastfeeding is temporarily discontinued.
In the case of violations of the functioning of internal organs, there are some limitations. For example, if you have liver problems, you should use caution during the treatment period and constantly monitor changes that occur with your health. Contraindications are only severe violations in the functioning of the body. The same applies to the work of the kidneys.
With regard to the appointment of funds from different manufacturers, including the drug Buspiron Sandoz, the doctors' testimonies testify to the need to comply with certain rules. When writing out a medicine, a specialist should take into account that this remedy is not able to eliminate withdrawal symptoms resulting from the use of benzodiazepines, and its appointment in such situations is not possible if the therapy has not been gradually phased out of the anxiolytic drug.
Patients should be aware that Buspirone tablets can affect care, especially at the initial stage of therapy, so it's best to temporarily refrain from activities that involve special responsibility and increased concentration of attention. Some tasks can be potentially hazardous to health.
Regarding therapy with Buspirone, doctors' reviews of the drug are mostly positive. However, experts note that it should be prescribed correctly only if there are appropriate indications and in optimal doses. It should be noted that with stress and anxiety, which appear due to the constant negative impact of everyday stressful situations, there is usually no need for treatment with anxiolytics.
Patients receiving "Buspirone" with different dosages, such as "Buspirone 10 mg" medications, the reviews show how to use an effective remedy. People who have been treated with this medication note that the doctor warned them about the caution of using certain medications, such as oral contraceptives, medications for diabetics, drugs that are aimed at lowering high blood pressure, drugs for eliminating depression and drugs such as cardiac glycosides, antipsychotics.
Inadequacy of kidney and liver of moderate severity, cirrhosis require reduction of standard doses. In these cases, the "Buspiron Sandoz" reception is described by people as a treatment that must be carried out under the supervision of a doctor. It is necessary to pay attention to the slightest changes in state of health.
Patients with epilepsy are never prescribed medication because of the risk of seizures. Such therapy for this category of patients is dangerous and should be carried out using other medications. Patients who often abuse drugs and have a history of drug dependence, should be treated under the strict supervision of a specialist( there were no cases of dependence on Buspirone).
Studies have shown that Buspirone is ineffective after 3-4 weeks of use with anxiety, so it makes no sense to treat it for a long time. Due to the lack of information on the safety of the drug for children, its designation is not made to persons under 18 years of age.
The treatment of different variants of the drug and Buspirone hexal is described by some experts as ineffective therapy because sleep problems, the appearance of irritability and anxiety are sometimes a sign of serious psychomotor disorders.
Analogues, reviews about the drug "Buspiron"
Replacement of the drug with an analogue should be performed after receiving a doctor's consultation. There is a good substitute for the medicine "Buspiron" - "Spitomin".The patient's feedback shows that his action is similar to that of the original remedy. Apply "Spitomin" to treat those conditions that stop and Buspiron. Reviews are good, so if necessary, you can use this substitute, but only after consulting a specialist. A similar effect is achieved due to the presence of the same active component. Spitomin is most effective in treating patients with anxiety disorders.
After treatment with Buspirone, patients can leave different responses, but mostly the result of this treatment is positive. Is it validated? The doctors' comments show that the agent with the active component of buspirone hydrochloride successfully fights with anxiety manifestations, different in severity and origin, but its effect is almost imperceptible at once, it can be seen only after a certain time, namely, in one or two weeks. To see the maximum possible therapeutic effect, one needs to be treated for one month.
"Buspirone" reviews patients gets positive in cases where there were no side effects, and with its task the drug handled perfectly. Sometimes there are negative reactions of the body, but very rarely, when the body does not perceive the components of the drug. From the reviews it became known that the treatment can be accompanied by psychotherapeutic and sociotherapy activities. Sometimes patients experience adverse gastrointestinal reactions, dizziness, and weakness. Overdose is a rare occurrence.
As a result of using Buspirone, patients who have received treatment are rarely left with information about serious side effects. The course should be based on individual characteristics of the human body, the state of its health, and in the optimal dose for each individual case. Despite the constant monitoring of the doctor, the patient is obliged to study the instructions before starting treatment.
Buspirone is a drug that usually does not lead to the development of side effects and overdose, does not cause addiction, negative manifestations after its withdrawal, and in most cases copes with its task.