Instructions for use "Magvita": a description of the drug, reviews
What are magnesium preparations for? This element is very important for the human body. With its lack, not only the heart and blood vessels suffer, but also other systems and organs. 
The most popular magnesium-containing drug is Magvit. Analogues of this tool, its cost and instructions are presented below.
Form of medicament, description, packaging, composition
In what form is the preparation under preparation? What does the instruction for use say?"Magwit" is a hard gelatin capsule with a size of 0.They are yellow and contain a white powder.
The main substances of this remedy are magnesium citrate and pyridoxine hydrochloride. Also said medicine includes potato starch, lactose and magnesium stearate.
The gelatin shell contains pharmaceutical gelatin, glycerol, methyl parahydroxybenzoate, purified water, propyl parahydroxybenzoate, titanium dioxide, sodium lauryl sulfate and dyes.
Magwit capsules are issued, the price of which is indicated below, in the cell outline packages and carton boxes.
Action of
How does the medication in question work? What information does the instruction manual contain?"Magvit" has a high efficiency, which is due to the properties of pyridoxine hydrochloride and magnesium.
Magnesium is known to be involved in the utilization, storage and transfer of energy, as well as the synthesis of nucleic acids and protein. This element controls and normalizes the balance of intracellular potassium, is a cofactor of mitochondrial processes and enzymatic reactions. 
Magnesium preparations are especially important for the brain. This element is a mandatory participant in the synthesis of all neuropeptides, RNA transcription and DNA replication.
The lack of magnesium in the human body is manifested by tremor, muscle weakness, ataxia, tetany, irritability, increased reflex excitability, heart rhythm disturbances, sleep disorders and diarrhea.
As for pyridoxine hydrochloride, this substance takes part in the synthesis of neurotransmitters and protein metabolism, and also improves fat metabolism in atherosclerosis. After entering the body, it is phosphorylated and converted to pyridoxal-five-phosphate. Also this component carries out reamination and decarboxylation of amino acids and transports them through cell membranes.
Pyridoxine hydrochloride is involved in the metabolism of glutamic acid, tryptophan, methionine and cysteine. It is necessary for the activation of phosphorylase and the formation of gamma-aminobutyric acid, neurotransmitters, serotonin and glycine. The element under consideration promotes the metabolism of vitamin B12 and folic acid. It takes part in the exchange of fatty unsaturated acids and the synthesis of porphyrins.
Main properties of
What properties does the Magvit drug have? The intake of this combined agent is justified by the following reasons: 
- vitamin B6 promotes an increase in the concentration of magnesium in erythrocytes and plasma, as well as reducing its withdrawal from the body;
- magnesium and vitamin B6 supplement each other's effects;
- magnesium activates the processes of transformation of pyridoxine into its derivative component( pyridoxal-five-phosphate) in the liver;
- vitamin B6 improves the absorption of magnesium from the intestine and its penetration into cells;
- vitamin B6 increases and fixes intracellular magnesium.
Kinetics of
How and where is the absorption of the agent in question? What does the instruction for use say?"Magwit" is absorbed from the digestive tract. Its absorption is 50% of the dose.
In the human body, magnesium is distributed in the intracellular space, and is excreted through the renal system.
Pyridoxine hydrochloride is absorbed from the small intestine. Together with the flow of blood, it spreads through the tissues and penetrates into the cells. There, vitamin B6 is phosphorylated by pyridoxalkinases and ATP.
The decomposition of coenzymes occurs by oxidation and dephosphorylation in tissues. Its product of catabolism is four-pyridoxic acid. It is excreted from the body together with urine. 
Indications
When should I use Magwit? The reviews state that this remedy is prescribed only if there is a deficiency of magnesium, isolated or associated with other human conditions.
Contraindications
The drug "Magvit"( B6 + magnesium) can not be taken with increased sensitivity to its ingredients, pronounced renal failure, in childhood and in phenylketonuria.
With caution, this remedy is recommended for use with moderate kidney failure. This is due to the fact that there is a large risk of hypermagnetism.
Instructions for use
"Magwit" should be taken only after consultation with the doctor. For adults, two capsules are administered orally three times a day. The duration of the course of treatment with this remedy is 30-60 days.
These capsules are taken only during meals, washed down with plain water. After the concentration of magnesium in the blood is normal, therapy should be discontinued.
Overdose cases of
When using large doses of medication, the following symptoms occur: sudden drop in blood pressure, vomiting, respiratory depression, nausea, delayed reflexes, cardiac arrest, coma, anuria and paralysis of the heart. 
For the treatment of such conditions, rehydration and forced diuresis are performed.
In the presence of renal failure, peritoneal dialysis or hemodialysis is required.
Side effects
This agent may cause allergic reactions. Also, disorders on the part of the digestive tract( for example, diarrhea, nausea, abdominal pain, vomiting, constipation or flatulence) are possible.
Interaction with other medicines
When prescribing the drug, "Magwit" should always inform your doctor about the use of other medicines, as they may be incompatible.
The parallel use of tablets containing calcium salts or phosphates can significantly reduce the absorption of magnesium from the digestive tract.
Magnesium-containing agents reduce the absorption of tetracycline. Therefore, before using the capsules "Magvit" should always observe the interval of 3 hours.
Magnesium is able to reduce the absorption of iron, as well as weaken the action of thrombolytic agents for oral administration. 
Pregnancy and lactation period
When pregnant, this medication can only be used according to the doctor's recommendations( strictly according to the indications).
According to experts, magnesium penetrates into the mother's milk rather well. Therefore, the use of the agent in question during breastfeeding should be avoided.
Recommendations for patients
With concomitant calcium deficiency, the lack of magnesium in the human body should be eliminated before the introduction of Ca preparations.
With regular use of laxatives, alcoholic beverages, and also with increased mental and physical loads, the need for magnesium in the patient increases. This can lead to the development of its lack in the body.
Terms and conditions of storage
This product has a shelf life of two years. The drug is prohibited to use later than the period indicated on the packaging.
The medicament in question is stored only in a dry place inaccessible to children and protected from the sun at a temperature of 15-28 degrees.
The cost of the drug and the like
How much does a drug like "Magwit" cost? The price of this complex is about 450-550 rubles. If this drug is not available in pharmacies in your city, it can be replaced by one of the following means: Magnelis B6, Magnesium plus B6, Magnerot, Magnesium-Diasporal 300.
The listed medicines have their own characteristics. Therefore, they can be used together with "Magvit" only on the recommendation of a doctor.
Comments of consumers
The drug "Magvit" is not the most popular drug containing magnesium and vitamin B6.However, there are a lot of reviews about it. 
According to the opinion of consumers, this medication effectively copes with its task. It eliminates the deficiency of magnesium in the body, which immediately affects the overall human condition.
It should also be noted that there are negative reviews about the drug in question. Some patients claim that taking this medication often causes them to have disorders in the digestive system. Moreover, many consumers are extremely unhappy with the price of this product. In their opinion, it is too high.