Acyloc in ampoules: instructions for use and reviews

The pace of modern life, constant stress, food culture, or rather, its lack( snacks on the run and fast food), the influence of various aggressive factors have a negative impact on the organs and systems of our body. The presence of peptic ulcer has long become familiar and does not cause surprise, and anti-ulcer drugs are in every home medicine cabinet. The pharmaceutical industry is actively developing such medicines. One of these medicines used in the therapy of peptic ulcer diseases is Acilok, which successfully copes with both treatment and prevention of ulcerative diseases of the gastrointestinal tract. About him and will be discussed in this article. acyl in ampoules

What is Acyloc?

According to the instructions for use, Acyloc in ampoules is an anti-ulcer drug of Indian origin, analogous to Zoran and Gistaka. Active active ingredient in it is ranitidine. Unlike other drugs, this medication is produced not only in tablet form, but also in the form of an injectable solution for intravenous or intramuscular injection, which allows the gastroenterologist to use the possibilities of the drug more widely. Although, of course, the usual form of drugs that reduce acidity in the stomach, are pills. But there are cases when it is necessary to administer the drug intravenously. It is for these cases that the described drug is suitable. The difference from tablets is that in one ampoule solution contains 50 mg of ranitidine - a single dose for injection. One tablet contains 150 mg of the active substance.

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What else informs about "Acyloca" in ampoules instruction manual? In the ampoule is not ready for injection. The agent must be diluted with sodium chloride, which may present certain disadvantages. The drug is a blocker of H2-histamine receptors, which are dislocated in the parietal cells of the gastric mucosa. Lining is called those cells that are responsible for the production of hydrochloric acid. Ranitidine suppresses the production of hydrochloric acid in the stomach and reduces the total volume of gastric juice by shifting its pH to the alkaline range, which automatically suppresses the activity of pepsin, which is one of the digestive enzymes. With a decrease in the amount of hydrochloric acid in the stomach, hepatic enzymes, which are associated with cytochrome P 450, are practically not suppressed, the concentration of gastrin in plasma is not reduced, and mucus synthesis is not suppressed."Acylok" is used for treatment and prevention of stomach and duodenum ulcers, as well as for some other disorders of the digestive system. The main active component of the drug contributes to strengthening the protective mechanisms of the gastric mucosa and potentiates the healing process of damage caused by hydrochloric acid( including facilitating the curing of stress ulcers and preventing gastric bleeding) by forming gastric mucus. This is confirmed by the instruction for the use of "Acyloca" in ampoules.

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Form release and composition

Available in the form of green tablets and solution for intramuscular and intravenous injection. The solution is transparent, its color can vary from colorless to pale yellow. In ampoules is 50 mg / 2 ml of solution, in a pack - 5 ampoules.

Indications for use

"Acylok" is used for the treatment of peptic ulcer of the stomach and duodenum in the acute phase;for the prevention of peptic ulcer disease, symptomatic ulcers, erosive and reflux esophagitis, Zollinger-Ellison syndrome. In addition, the described preparation is used as preventive measures for "stressful" ulcers of the digestive system, postoperative ulcers, relapses of bleeding in the upper parts of the digestive system, and for aspiration of gastric juice during anesthesia. acyl in ampoules instruction manual for dogs

Dosage

According to the instructions for use, "Aciloc" in appululars for exacerbation of gastric ulcer and duodenal ulcer is prescribed by 50 mg solution intravenously or intramuscularly twice a day( morning and evening) or once a day, but in a double dose. In some cases, the dose may be doubled. Duration of treatment - up to two weeks. At the time of remission, to prevent recurrence, the drug is prescribed one ampoule once a day, and patients who smoke should receive a double dose, since nicotine suppresses the action of ranitidine.

If a person took non-steroidal anti-inflammatory drugs, and the ulcer is caused precisely by this, the dosage according to the instructions for the use of "Acyloca" in ampoules remains the same, and the duration of treatment can increase. The so-called "aspirin ulcers"( a peptic ulcer provoked by NSAIDs) are treated with a 50 mg dose twice a day. The same dosage is used in the treatment of erosive reflux esophagitis( a disease in which the contents of the stomach enter the esophagus, which irritates the mucosa and causes its inflammation).For preventive purposes, 50 mg intravenously( preferably slow administration) or intramuscularly every 6-8 hours is administered to prevent ulcerative bleeding.

Administration of the solution continues until the patient can not take food alone. Attached to the "Acyloca" in ampoules instructions for use for people detailed and understandable.

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For the prevention of Mendelssohn syndrome( this condition in pneumonia, which is caused by throwing gastric juice into the trachea and bronchi), the drug is administered at a dosage of 50 mg intramuscularly or intravenously slowly 45-60 minutes before anesthesia is injected. Injection administration of this drug is indicated in those cases when taking tablets for any reason is impossible. Usually diluted with sodium chloride, the drug is administered intravenously slowly for five minutes. If necessary, the medication is repeated every 6-8 hours. Intramuscularly, the solution is administered 50 mg to 4 times a day. After intramuscular or intravenous administration of the drug, it is completely absorbed. The maximum concentration of the substance in the body is reached 15 minutes after the administration. Approximately 30% of the received amount of the drug is excreted from the body with urine unchanged. In patients with liver or kidney disease, the rate of drug withdrawal is reduced, which should be taken into account in the appointment. What recommendations give to the drug "Acylok" in ampoules instruction for use for pregnant women?

Contraindications

Pregnancy and breastfeeding are contraindications for the use of this medication. If, with natural feeding, there is a need for taking this medication, then the child must be transferred to artificial nutrition. Clinical studies on the use of this medication in pediatrics have not been carried out, therefore in childhood it is not used, the medicine can be prescribed from the age of twelve. When there is an individual intolerance of the components of the drug, it is canceled. acyl in ampoules instructions for use in animals

Side effects of

In rare cases with intravenous administration, there are cardiovascular disorders. The digestive system can respond with nausea, diarrhea, abdominal pain, or constipation. In isolated cases, hepatitis can be observed. In very rare cases, such adverse events as headaches, dizziness, fatigue, blurred vision were recorded. In seriously ill patients, confusion and hallucinations were extremely rare. Prolonged use of high doses of the drug may trigger leukopenia and thrombocytopenia. The drug also slightly increases the creatinine in the blood at the initial stage of treatment, as well as increases the activity of gamma-glutamyl transpeptidase.

Adverse events

The endocrine system can respond to long-term administration of large doses of the drug with increased prolactin levels, gynecomastia, amenorrhea, impotence, decreased libido. Allergic reactions occur extremely rarely and are usually expressed in the form of urticaria, itching, angioedema, anaphylactic shock, bronchospasm, arterial hypotension. With rapid intravenous administration of the drug, bradycardia may occur, especially in patients with a disturbed cardiovascular rhythm. In the special literature there are cases of development after acute "Acilocom" treatment of acute attacks of porphyria, in connection with this, patients suffering from this disease, the drug can not be prescribed.

As indicated in the instructions attached to the "Acyloc" in the ampoules, the instructions for use are also used for animals. About this below. acyl in ampoules instructions for use for humans

Application of

Before starting treatment, the presence of malignant formations in the esophagus, stomach or duodenum should be ruled out. Long-term treatment of weakened patients under stressful conditions can be complicated by bacterial gastric damage with further spread of infection. A sharp interruption in the reception of ranitidine is fraught with a relapse of peptic ulcer. The effect of the preventive use of this drug is much higher if treatment is carried out in courses in the fall and spring than with a constant intake.

Special instructions

When using "Acyloca" is not recommended to eat food, drinks and other medicines that can irritatively affect the gastric mucosa. Also it is necessary to be cautious about car driving and other actions that require increased concentration of attention and active psychomotor reactions. The joint intake of this drug with antacids, sucralfates, which slow the absorption of ranitidine, should assume a break between taking these drugs for at least two hours.

Analogs of

We got acquainted with what is written about the "Acyloc" in ampoules instruction manual. Analogs of the drug have a similar effect on the body. These include Ranitidin, Gistak, Duoran, Ranigast, Ulkosan.

Reviews

According to the patients receiving the injection of "Aciloka", it is a good aid in the treatment of peptic ulcer disease, ulcers are cicatrized in a very short time and relapse of the disease is not observed. However, some patients noted a side effect such as severe thirst, which continues all the time, while treatment with this drug lasts. But on the whole, patients' feedback and opinions of specialists about the use of this drug have a positive color.

We reviewed the instructions for use and patient reviews attached to the drug Acilok in ampoules.

Use in animals

According to the instructions for use, "Acyl" in ampoules for dogs is often used in the treatment of animals with gastrointestinal diseases. acyl in ampoules instructions for use for pregnant women Scheme is as follows:

  • In case of an ulcer, the drug is given regardless of feeding. For the treatment of the acute phase - 150 mg 2 times a day. For large breeds - 300 mg twice a day. Therapy is prolonged, up to four weeks.
  • With Zolinger-Ellison syndrome, 150 mg three times a day. When reflux esophagitis - 300 mg once a day, Mendelssohn syndrome - 150 mg per day before anesthesia and 150 mg two hours before anesthesia.

As recommended for the "Acyloc" in the ampoules instructions for use, this medicine is also suitable for cats. Dose - 1-2 mg per 1 kg of animal mass intravenously or intramuscularly, twice a day.