"Dorzopt"( eye drops): instructions, reviews, analogues

Glaucoma is a fairly large group of eye diseases characterized by a periodic or constant increase in intraocular pressure, followed by the development of defects, optic atrophy and reduced visual acuity. dorsopt eye drops

Various drugs are used to treat such diseases. The most common medication is Dorzopt( eye drops).Comments from consumers, instructions for using this medication will be discussed below.

Packaging and Composition

What substances contains the drug Dorzopt( eye drops)?The active component of this drug is dorzolamide( in the form of hydrochloride).Also in the composition of the medicament are the following auxiliary compounds: benzalkonium chloride, hyetellose, mannitol, sodium hydroxide, citric acid monohydrate, distilled water.

This preparation is available in 5 ml polyethylene bottles with a dropper nozzle.

Pharmacodynamics

What are Eye Drops of Dorzopt? The instruction states that this agent is a local inhibitor of carbonic anhydrase. It has a depressing effect on the secretion of the intraocular fluid and slows the formation of bicarbonate, and also impairs the transport of water and sodium.

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This medication does not cause miosis or hemostalopia, as well as spasm of accommodation.

Pharmacokinetics

Is the drug "Dorzopt"( eye drops) absorbed? Absorption of this medication occurs through the cornea, as well as through the limbus and sclera. The indicators of systemic absorption of medicament are very low.

When entering the bloodstream, the active substance of the drug quickly penetrates into red blood cells with a high content of carbonic anhydrase 2.

The connection with plasma proteins occurs by 33%.The drug is converted to an N-desethylated metabolite, which is not very active against carbonic anhydrase 2, but is able to block the carbonic anhydrase 1.

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Prolonged use of the drug leads to its accumulation in red blood cells.

Drug is withdrawn through the kidneys. Its cancellation has 2 phases of elimination: fast and slow. The latter is due to the gradual release of the active component from the erythrocytes.

The half-life of the drug is about 4 months.

Indications

When do they prescribe Dorzopt? Eye drops are very effective in treating increased intraocular pressure in people with ocular hypertension, open-angle or pseudoexfoliation glaucoma( including secondary glaucoma).

Contraindications

When should I not use Dorsopt? Eye drops are not prescribed for:

  • hyperchloremic acidosis;
  • hypersensitivity to constituent elements;
  • severe renal dysfunction;
  • at a minor age;
  • during the lactation period.

With special care, this remedy should be used:

  • for diabetes mellitus;
  • for patients with hepatic insufficiency;
  • to people with a small density of endothelial cells in the cornea of ​​the eye( due to the high likelihood of corneal edema).

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How to use

The prescribed agent for the treatment of eye diseases should be prescribed only by a narrow specialist after a thorough examination of the patient. Bury the drug preferably one drop in the conjunctival sac three times a day.

When the drug is combined with local beta-blockers, the drug should be used one drop twice a day.

If eye disease therapy includes several ophthalmic agents, then the interval between their instillation should be at least ten minutes.

Side effects of

When using Dorsopt eye drops, the following local reactions can develop in patients:

  • Itching and burning in the eye area, conjunctivitis, paresthesia, eyelid edema, lacrimation, blepharitis, visual impairment, photophobia and superficial keratitis.
  • Very rarely on the background of the use of this drug there are: iridocyclitis, increased corneal thickness, allergies, eye hypotension, as well as retinal detachment after antiglaucomatous operations.

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Systemic side effects:

  • sensation of nausea, bitterness in the mouth, development of nephrourolythiasis, asthenia, migraine, malignant exudative erythema, toxic epidermal necrolysis, aplastic anemia, skin rashes and agranulocytosis.

Cases of an overdose of

What are the symptoms when using increased doses of Dorsopt? Eye drops, analogues of which are presented below, can contribute to:

  • development of acidosis;
  • disturbance of water-electrolyte balance;
  • disorders from the central nervous system.

For the treatment of such conditions, symptomatic therapy is used, accompanied by monitoring of electrolyte levels and blood pH.

Drug Interaction

  • When the drug is combined with antiglaucoma drugs( beta-blockers, "Dipyvefrin", "Pilocarpine", "Carbachol"), its effect is enhanced.
  • "Acetazolamide" increases the risk of systemic side effects.
  • With higher dosages of acetylsalicylic acid, the toxicity of the drug increases.

Special recommendations

The use of multi-dose vials can provoke the development of bacterial keratitis. This is due to the unintentional contamination of their contents.

In the process of treatment Doorsopt should not use lenses, since benzalkonium chloride can cause toxic effects and cause eye irritation.

Analogues and price of the medicine

You can replace the eye drug in question with tools such as Trusopt and Floxal. The price of this medication is about 350 rubles. dorsopt eye drops analogs

Feedback from consumers

Unfortunately, customer feedback about the drug "Dorzopt" is rare. Among the main advantages of this medicine are noted such as accessibility and effectiveness. However, some consumers are concerned about local and systemic adverse reactions that occur when droplets are applied. In this regard, specialists can recommend the use of a drug called Dorzopt Plus.

The eye drops mentioned above include an additional substance such as timolol. It promotes the outflow of intraocular fluid.