"Nifuroxazide" for the child: instructions for use and reviews
Diarrhea is a symptom characterized by the appearance of a loose stool, increased peristalsis of the gastrointestinal tract, and discomfort in the abdomen. Often such disorders are associated with the penetration of pathogenic microorganisms and their reproduction in the lumen of the gastrointestinal tract. Its special features are the treatment of diarrhea in children due to rapid dehydration of the body and the occurrence of concomitant complications. Let's see how to deal with the disorder of the stool with the help of the drug "Nifuroxazide" for the child.
Pharmacological features of
"Nifuroxazide" is an antimicrobial drug from the group of nitrofurans, mainly used as an intestinal antiseptic. The mechanism of action of this drug is based on inhibition of dehydrogenases, the Krebs cycle and cellular respiration.
In addition, "Nifuroxazide" violates the processes of protein synthesis in the cell, which disrupts the vital activity of the microorganism.
When administered orally, the drug has a low bioavailability, that is, it is not practically absorbed into the systemic circulation. Plasma concentrations of nifuroxazide can be detected in the blood plasma, while a small amount of it is excreted in the urine unchanged. The rest is allocated with caloric masses. In view of the almost complete absence of absorption, the rate of excretion of the drug depends on the dose taken and the intensity of intestinal motility.
Spectrum of the action of the drug
In terms of nitrofuran derivatives, "Nifuroxazide" has a bacteriostatic effect in the average therapeutic concentrations, and in higher doses acts as a bactericidal drug with a slow development of resistance. The drug is sensitive to a fairly large number of both gram-positive( streptococci, penicillinase-producing staphylococcus), and Gram-negative microorganisms( Escherichia coli, Salmonella, Shigella, Klebsiella, enterobacteria).In addition, the medicine negatively affects various viruses, Trichomonases, lamblia and fungi of the genus Candida. The drug retains its effect in the presence of pus and other products of tissue decay in the wound.
"Nifuroxazide" is ineffective in the treatment of pseudomonasive infections, as well as infections caused by microorganisms of the genus Proteus.
Indications for the use of the drug "Nifuroxazide"( instruction for children)
The main indication for the prescription of the drug are various kinds of infections of the intestinal localization caused by susceptible antibacterial agents."Nifuroxazide" is prescribed for acute stool disorder of infectious genesis, chronic inflammatory bowel diseases and enterocolitis. The drug is prescribed for patients with infected wounds( possibly local application of the drug), as well as for surgical interventions on the intestines( for sanitation) and for the complex treatment of dysbiosis.
It should be noted that in pediatric practice, the most commonly used drug for the treatment of intestinal disorders is Nifuroxazide. Instruction for children, except for dosage, is similar to that for adults.
Method of administration and dose
The use of the drug is carried out regardless of the meal. For treatment of adults, and also children after the age of seven, the drug is taken 1 tablet( 200 mg) three or four times a day. This dose for one dose corresponds to 5 ml of suspension or syrup "Nifuroxazide".Instructions for use for children and adults indicate that after the normalization of the stool, taking the drug should be continued for 3-4 days. The course of treatment should not exceed a week. If the drug is ineffective for a long time, the approach to therapy should be reviewed.
For preschool children, dosage should be reduced to 100-150 mg per one dose of Nifuroxazide. Syrup for children is an excellent treatment option. In this case, the multiplicity of the application of the remedy remains the same. If there is no medicine in the form of a syrup at hand, you can crush a 200 mg tablet half-and-half between two tablespoons to a powdery consistency and give the baby with a little water or breast milk. In all other cases it is recommended to use liquid "Nifuroxazide"( suspension for children).
Side Effects of
With the use of preparations of the group of nitrofurans, side reactions from the digestive tract most often occur, which is directly related to the site of action of the drug. When taking Nifuroxazide medication for a child, there is a risk of developing dyspeptic disorders, cholestasis, and hepatitis. With a low degree of probability, there may be a reaction of individual intolerance to the drug by patients, which is accompanied by the occurrence of nausea, vomiting, abdominal pain, diarrhea. In the latter case, with a slight exacerbation of symptoms should not stop treatment, as the negative manifestations quickly pass and are associated with the onset of action of the medication. In the presence of severe symptoms and worsening of the general well-being of the patient, the drug should be stopped.
The adverse effect of the drug on the central nervous system is marked by the appearance of neuritis. Allergic reactions are manifested in the form of skin rash, itching, hives, pustules. In severe cases, hypersensitivity reactions may occur, including anaphylactic shock or angioedema. The administration of the drug is rarely accompanied by disorders on the part of the hematopoiesis system.
Special instructions for taking
Recall that therapy with the drug "Nifuroxazide" should not last more than 7 days. In the case of persistent diarrhea, the symptoms of which can not be suppressed for three days, it is necessary to reconsider the treatment tactic towards the appointment of antibiotics. In the case of severe diarrhea and the presence of symptoms of dehydration, in parallel with the appointment of "Nifuroxazide", rehydration therapy and concomitant symptomatic treatment are performed.
The composition of the drug includes lactose, so patients suffering from a violation of digestion of this substance, the use of the drug should be limited or completely discontinued. Against the background of taking "Nifuroxazide" it is not recommended to prescribe other oral medications because of their effectiveness decrease, which is due to the presence of sorption properties of the active substance. When using the medication, alcohol intake is contraindicated, as this can lead to disulfiram-like reactions, which are accompanied by disorders from the central nervous system( noise and ringing in the ears), flushing of the skin, tachycardia, a sense of fear.
According to the official information on the drug "Nifuroxazide"( instruction), a suspension for children and syrup can reduce the appearance of adverse reactions from the intestine.
Use during pregnancy and lactation.
. There is no single-valued data that indicates the dangers of taking the drug during pregnancy and lactation. Given that "Nifuroxazide" is not absorbed from the lumen of the gastrointestinal tract and does not penetrate breast milk, the purpose of such a drug is possible if the potential positive effect on the maternal organism is higher than the effect on the fetus.
Poisoning and overdose
Because of low bioavailability, symptoms of poisoning are unknown. When taking large doses of the drug recommended gastric lavage and prompt treatment for qualified medical help.
In the pharmaceutical market, "Nifuroxazide" is available as a suspension for oral administration( 200 mg or 220 mg of active substance per 5 ml of suspension, 90 ml bottle), tablets for oral administration( 100 mg or 200 mg per tablet) orcapsules( 200 mg of the drug in 1 capsule).Each patient can choose for himself a suitable form of release.
In what form do they most often buy Nifuroxazide? Syrup for children is more in demand, because kids are more prone to intestinal infections.
The drug is also issued under the name "Enterofuril", "Ercefuril" in the form of capsules( 100 or 200 mg each) and a suspension for oral administration containing in 200 ml of active ingredient( nifuroxazide).The instruction for the use of analogues for children is practically the same as the original. However, before using the drug, it should still be carefully examined.
"Nifuroxazide" for children: reviews
This medication is used not only in pediatrics, but also in the practice of internal medicine. Virtually all reviews on the use of "Nifuroxazide" in children are positive. This is due to its effectiveness in the treatment of various kinds of disorders of the functioning of the gastrointestinal tract, as well as the availability of conveniently dosed forms of the drug in the form of suspension and syrup.
In addition, "Nifuroxazide" for a child is a sufficiently safe drug, which causes its wide application in clinical practice.
"Nifuroxazide" for a child is the most effective drug that helps to quickly cope with diarrhea of infectious genesis. The safety of the drug is due to its low bioavailability, and high efficiency - only in the lumen of the gastrointestinal tract. According to official information on the drug "Nifuroxazide"( instruction), a suspension for children and syrup are the more preferred forms. Tablets, as a rule, are assigned to adults.