"Kondronova": instructions for use, description of the drug, feedback
Osteoarthritis is a degenerative-dystrophic joint disease. Its cause of development is the destruction of cartilaginous tissues located on articular surfaces. Such a pathological condition can arise due to trauma, dysplasia and inflammation.
Quite often this disease is inherited. It also develops due to excessive body weight, in old age and due to a specific profession.
To restore cartilaginous tissues on articular surfaces, doctors prescribe special preparations to patients. One of them is the medication Kondronova. The price of this medication will be presented further. Also in the materials of this article you will find instructions on the use of this drug, its properties, analogs, form of release and contraindications.
Composition, form and packaging
In what form is the Kondronova medication manufactured? Reviews of consumers say that this medicine is available in capsules. They are placed in blisters or contained in jars of PVC( placed in cardboard bundles).
What substances does the "Kondronova" preparation contain? The tablets have the following active ingredients: glucosamine sulfate and chondroitin sulfate.
Also it should be said that the composition of the drug in question includes auxiliary ingredients in the form of mannitol, magnesium stearate, croscarmellose sodium and purified talc.
The capsule shell consists of water, gelatin, sodium lauryl sulfate, povidone, bronopol, titanium dioxide dye, dye of brilliant blue and dye quinoline yellow.
Mechanism of action
What are the Kondronov capsules? Instruction for use reports that this is a tool that stimulates the regeneration of cartilaginous tissues. Its effectiveness is due to the components that make up the composition.
Chondroitin and glucosamine sulfate are involved in the synthesis of connective tissues, and also contribute to the prevention of cartilage destruction processes and stimulate regeneration.
The use of exogenous glucosamine improves the production of a cartilage matrix, providing it with non-specific protection against possible chemical damage.
Glucosamine in the form of a sulfate salt is a precursor of hexosamine. As for sulfate-anion, it is required for the synthesis of glycosaminoglycans.
It should also be noted that another function of glucosamine is to protect the damaged cartilage from metabolic damage, which is caused by the intake of GCS and NSAIDs. In addition, this substance has a moderate anti-inflammatory effect.
What other properties does the "Kondronova" medication have? Capsules containing chondroitin sulfate serve as an additional means for the formation of healthy cartilage. This fact does not depend on whether the drug is absorbed in intact form or as separate elements.
It can not be said that this substance can stimulate the formation of hyaluronone, collagen type II and the synthesis of proteoglycans, as well as protect hyaluronone from enzymatic degradation( by suppressing the activity of hyaluronidase) and damaging effects of free radicals.
According to experts, chondroitin sulfate not only maintains the viscosity of the fluid synovial, but also stimulates mechanisms of cartilage repair, suppressing the activity of those components that split it( for example, elastases or hyaluronidases).
So, what is remarkable about the Kondronov medication? The reviews state that when treating osteoarthritis, it significantly alleviates the symptoms of the disease and reduces the need for patients to take NSAIDs.
Kinetics of the drug
Consider the kinetic properties of each component in more detail.
The bioavailability of this substance when administered orally is 25%.
It is distributed in tissues. Maximum concentrations of the element are found in articular cartilage, liver and kidneys. Approximately 30% of the dose taken persists for a long time in the muscle and bone tissues.
Glucosamine is excreted along with urine and feces for 68 hours.
- Chondroitin sulfate.
Taking this element inside at a dosage of 800 mg promotes an increase in its concentration in the blood during the day. Absolute bioavailability is 12%.Approximately 10% and 20% of the dose taken is absorbed in the form of high molecular weight metabolites and low molecular weight derivatives.
Chondroitin sulfate is excreted in urine for 5 hours.
At what diseases are capsules "Kondronova" appointed? Instructions for use indicate that this tool is actively used for the therapy of osteoarthritis in the 1-3 stages.
When should you not take Kondronova tablets, the analogues of which are listed below? According to the instruction, contraindications to the use of this medication are the following:
- the presence of hypersensitivity;
- gestation period;
- time of breastfeeding;
- is a minor age.
Capsules "Kondronova": instruction on the use of
On how to take this medication, the patient should be told by the doctor in charge. Only an experienced specialist, relying on analysis data and general information from a medical examination, will be able to select the right therapy regimen and prescribe an effective treatment.
According to the instructions, capsules for osteoarthritis 1-3 stages should be taken only inwards. Perform such treatment procedures should be 25 minutes before eating. In this case, the drug should be washed down with a glass of water.
Adult patients usually receive this medication in two capsules twice or thrice a day.
The duration of treatment with Kondronova is 1-2 months. If required, the course is repeated.
Side effects of
What unwanted reactions can the "Kondronova" medication cause? Instructions for use indicate that its active components have different effects on the patient's body.
Side effects when taking capsules may act:
- Because of chondroitin: allergic reactions.
- Because of glucosamine: a gastrointestinal disturbance( flatulence, epigastric pain, constipation or, conversely, diarrhea), skin allergic reactions, dizziness, pain in the legs, headache, peripheral edema, tachycardia, drowsiness and insomnia.
Drug interaction and overdose
The drug "Kondronova" increases the absorption of tetracyclines, and also worsens the action of glucosamine and semi-synthetic penicillins. In addition, this medication is compatible with GCS and NSAIDs.
Symptoms of an overdose of Kondronova are unknown.
Capsules "Kondronova": price and similar products
Depending on the number of capsules in the package, the drug in question can have different prices( from 290 rubles).
If this medication is contraindicated to the patient, then it is replaced by one of such means as "Chondroglucid", "Teraflex" or "Artra".
Consumer reviews about this drug are mostly positive. Patients claim that this remedy significantly improves the condition of the joints, and therefore relieve the pain associated with osteoarthritis.
The opinion of consumers is fully agreed and experienced experts. They have repeatedly been convinced of the high efficiency and effectiveness of the drug. He restores cartilaginous tissue and reduces the patient's need for NSAIDs.