Ladisan: instructions for use, reviews
What do patients say about Ladisan? Instructions for use, reviews will be discussed further. Also, we will tell you about what this remedy is for, whether it has contraindications and side reactions.
In what form are the medicines "Ladisan" made? Instruction for use informs that this product can be purchased in the following dosage forms:
- Round tablets coated with a tablet and containing 50 or 25 mg of active ingredient - maprotiline hydrochloride.
Also contemplated include additional substances such as lactose, corn starch, talc, calcium phosphate, dyes, gelatin, colloidal silica, polysorbate-80 and hypromellose. On sale this medicine comes in blisters, which are packed in cardboard boxes.
- Solution for infusions "Ladisan".The instruction says that it has full transparency, and also has no color and is intended for intravenous infusions.
1 ml of the drug solution contains maprotiline methanesulfonate in an amount of 5 mg. Also in the composition of the medicament are auxiliary components in the form of water for injection, mannitol and methanesulfonic acid. The drug goes on sale in ampoules of 5 ml, made of colorless glass.
Pharmacology of the medical device
What is the medicine "Ladisan"?Instruction, reviews indicate that this is a drug that belongs to the group of norepinephrine and serotonin reuptake inhibitors. In other words, this medication is an antidepressant of the tetracyclic structure.
The pharmacological action of the active component of this agent consists in the suspension of the reuptake( neuronal) norepinephrine and neurotransmitters of serotonin by the presynoptic membranes of neurons of the brain.
This medication is distinguished by the correct combination of all the basic properties of drugs from depression. The use of this medicine raises the mood to the patient, removes the habitual feelings of fear, contributes to the elimination of the excited state, and also removes the various somatic disorders and psychomotor retardation that are characteristic of the disguised depression.
How quickly the action of the medicine "Ladisan" comes in? Instruction for use says that this drug shows its properties fairly quickly. The therapeutic effect after the use of the agent can be observed after a few days.
It should also be noted that this antidepressant is well tolerated by the human body. That is why he received the widest distribution in outpatient care.
Indications for the use of medication
In what cases can a patient be prescribed a drug such as Ladisan? The doctors' comments state that it is expedient to use this remedy for various types and manifestations of depression:
- endogenous( cyclic, involutionary and periodic);
- is somatogenic( organic and symptomatic);
- psychogenic( depression depletion, reactive and neurotic);
- disguised forms of depression;
- depressed menopause.
It should also be noted that this medication can be used in other disorders that are accompanied by the following symptoms:
- irritability or dysphoria;
- with a sense of fear.
According to the patients' reviews, this medication has a beneficial effect on psychosomatic and somatic disorders that have arisen against a background of anguish or a sense of fear.
The medicament in question can not be used in the following cases:
- first trimester of pregnancy;
- hypersensitivity to the main component;
- acute myocardial infarction;
- arrhythmia of the heart.
When should I not prescribe the antidepressant "Ladisan"?Instruction for use informs that with special care this medicine is recommended for patients with impaired renal or hepatic function, as well as with increased pressure( intraocular) and disorders of urination( including prostate gland diseases).
If this medication is used for a long time, patients should regularly undergo ECG and monitor heart function. This is especially true for those who suffer from cardiovascular diseases, including those of advanced age.
Patients who are prone to orthostatic hypotension should regularly check their blood pressure at the time of taking the medication.
It should be noted that, like other psychotropic drugs, this antidepressant significantly reduces a person's tolerance to alcohol.
What else do you need to know before using the medicine "Ladisan"?The patients' reviews say that the drug in tablet form negatively affects their psychophysical reactions, especially if it was taken concomitantly with ethanol or medications that have a depressive effect on the central nervous system.
It should also be noted that when using the infusion solution of Ladisan, attention and reactions are often disturbed in patients. Therefore, during therapy with this drug, patients are forbidden to drive vehicles and manage dangerous mechanisms.
Antidepressant "Ladisan": instructions for use
The dosage of the drug in question is selected individually for each patient. As a rule, it depends on the severity of the disease.
Experts argue that a decrease or increase in the evening dosage of this remedy is allowed only if the daily dose is increased or decreased. Also, the daily amount of the drug can be taken at one time, preferably in the evening.
After achieving a positive effect, doctors recommend reducing the dose of medication. However, with the manifestation of repeated symptoms of depression, you must immediately return to the previous treatment regimen.
So how should you use Ladisan tablets? Instruction for use informs that this form of the drug is intended for oral administration.
As a rule, with ambulatory therapy of depression, the drug in question is prescribed in an amount of 25 mg three times a day or 50-75 mg once, in the evening.
If depression is very difficult, then it should be treated in a hospital setting. With this diagnosis, the daily dosage of the drug can be increased to 150 mg.
Regarding the infusion solution, it is usually recommended to inject it with freshly depressed severe depression or if the oral medication treatment has not produced the desired effect.
The daily dose of the drug for intravenous drip infusion is about 25-100 mg. To prepare the drug solution, the contents of the two ampoules should be dissolved in 250 ml of a solution of sodium chloride or glucose. Next, the finished product must be slowly injected into the vein( for 2 hours).
If a patient needs a high dose of medication, then the infusion time is increased to 3 hours.
Usually, after the first 2 weeks of treatment with an antidepressant, the patient is transferred to an oral treatment with an infusion solution.
According to reviews of the majority of consumers, in the early days of Ladisan, it can cause fatigue, as well as anticholinergic effects such as dry mouth, constipation, accommodation and dizziness.
In very rare cases, against the background of using the drug in question, the patient has a decrease in blood pressure and tachycardia. Also, skin reactions are possible, which are associated with hypersensitivity of the patient to maprotilene. In this case, you must stop taking the medication.
Cases of overdose
According to the instructions, if not properly used, the "Ladisan" antidepressant can cause symptoms of an overdose. As a rule, they develop 4 hours after taking the drug and reach their maximum after a day.
The following conditions refer to signs of overdose:
- CNS depression or exacerbation( including convulsions, restlessness, muscle rigidity, drowsiness, stupor and coma);
- disorders of the blood vessels and heart( tachycardia, arrhythmia, arterial hypotension and heart failure).
Sometimes, an overdose of the drug in question may trigger vomiting, fever, cyanosis, mydriasis, anuria, increased sweating, and oliguria. In this case, symptomatic treatment should be immediately performed.
The drug "Ladisan": reviews of patients
There is not much information about the antidepressant "Ladisan".In those that are available, patients claim that this drug is quite effective and effective. With proper use, the drug helps to eliminate depressive disorders, as well as apathy, feelings of fear and irritability. However, it should be noted that this agent can cause side reactions, so it should only be assigned by an experienced specialist.