Russian and foreign analogues of "Erythromycin": description, prices, reviews. What can replace drugs based on erythromycin?
For bacterial infections that have affected the respiratory tract, genitourinary sphere or other organs, physicians prescribe systemic antibacterial agents. To get rid of a number of gram-positive or gram-negative microorganisms, alpha-hemolytic streptococcus, mycoplasma, chlamydia and other bacteria can be done with the help of "Erythromycin".Analogues of this drug with the same active substance are also effective.
The Erythromycin tablets contain 500 mg of the same active ingredient. It is an antibacterial drug belonging to the macrolide group. Its action is based on the fact that it is able to disrupt the formation of peptide bonds between amino acids and block the process of protein synthesis in pathogenic microorganisms. It does not affect nucleic acids in any way.
But the active substance erythromycin in the tissues of the body is distributed unevenly. It accumulates in the kidneys, liver and spleen. The concentration of antibiotic in urine and bile is several times higher than in blood plasma. Erythromycin is able to penetrate well into the tissues of the lymph nodes, lungs, middle ear exudates, semen, the secretion of the prostate gland, synovial and ascitic fluids, the pleural cavity.
Indication: when is the drug prescribed
Before searching for the analogues of "Erythromycin", you need to understand the indications for taking this remedy. It can be used in cases when the disease is caused by microorganisms that are sensitive to this antibiotic. These are the following pathologies:
- scarlet fever;
- conjunctivitis in newborns;
- infections of the upper respiratory tract( bronchitis, tracheitis, pneumonia);
- primary syphilis;
- urogenital infections in expectant mothers;
- uncomplicated chlamydia;
- infectious lesions of ENT organs( otitis, sinusitis, tonsillitis);
- bacterial lesions of the biliary tract( cholecystitis);
- eye infections( mucosal problems);
- pustular lesions on the skin, bedsores, trophic ulcers, burns.
Patients with rheumatism use "Erythromycin"( analogues of the drug are also suitable) for the prevention of the development of streptococcal infections. He is also prescribed for dental operations, during preoperative preparation, before endoscopy.
Possible substitutes for
If a physician prescribing treatment to a patient indicates that a drug with an active substance erythromycin is needed, then a person can choose the most suitable drug in the pharmacy himself.
These can be Erythromycin tablets with enteric coating. Also, the pharmacist can recommend the drug "Erythromycin-LECT", "Erythromycin Phosphate".Also on sale you can find preparations "Eryfluid", "Erythromycin-Ferein", "Synerit", syrups "Grunamycin", "Ilozon".
If necessary, the doctor can prescribe systemic antibacterial agents with another active substance. This is done in cases where the patient has contraindications to the use of drugs made on the basis of erythromycin. Prescribed can be antibiotics such as Clacid, Macroben, Sumamed, Fromilide, Azithromycin, Azax, Zitrolide.
List of contraindications
Before you start drinking the original drug or Erythromycin analogues, you need to find out if you can use these drugs. After all, the list of situations in which they should be abandoned is quite wide. The most common include:
- the period of lactation;
- hearing loss;
- established hypersensitivity to erythromycin;
- the need to receive funds "Astemizol" or "Terfenadin".
If a history of jaundice, arrhythmias, renal or hepatic insufficiency, prolongation of the QT interval on a cardiogram, it is also better to replace it.
Reported complications when taking
It is necessary to discontinue use of the drug even if there are any side effects. In this case, it is desirable to choose the analogues of "Erythromycin" with another active substance. Among the side effects may be:
- skin reactions( rash, urticaria);
- eosinophilia, increased activity of hepatic transaminases;
- diarrhea, nausea and vomiting;
- pain in the abdominal region;
- pseudomembranous enterocolitis;
- cholestatic jaundice;
- the appearance of noise in the ears;
- hearing loss;
- some people have tachycardia, ventricular arrhythmias on the background of admission;
- in very rare cases, anaphylactic shock occurs.
Before going to the pharmacy and picking up a modern analogue to the drug "Erythromycin", you need to determine the form in which the drug you need. On sale, you can find tablets, ointment, powder or granules for the preparation of suspension and lyophilizate for injection.
In most cases, the drug is prescribed in the form of tablets. But if patients need intensive therapy, and the treatment is carried out in the hospital, they can prescribe intravenous administration of the drug. The solution can be injected with a slow injection for 3-5 minutes or drip - depending on the doctor's recommendations.
Ointment is prescribed for the treatment of pustular lesions of the skin, including youthful acne. It must be applied to all areas of the lesion. When infectious and inflammatory problems with the eyes use a special ointment, which must be laid for the lower eyelid.
Powder and granules are used for the preparation of a suspension. They, as a rule, are prescribed to children who find it difficult to find the necessary dosage in tablets.
If you do not want to spend too much money buying the analogues of "Erythromycin", tablets can be taken from Russian production. In the pharmacy you can find "Erythromycin-AKOS", produced by JSC "Sintez"( Kurgan).
If you want to inject the drug as an injection, you can buy erythromycin phosphate. It is made by the same Russian company Sintez.
Also in Russia produce "Erythromycin-LECT" at the Tyumen Chemical-Pharmaceutical Plant. In addition, the original product "Erythromycin" produced by Sintez, Biosintez, Tatkhimpharmpreparaty, NIZHFARM, and Bryntsalov-A can be found on sale.
Many refuse from domestic preparations, even if they are prescribed the drug "Erythromycin".It is not difficult to choose an analogue for import, because many preparations are made on the basis of this active substance.
If you need to buy a solution for intravenous administration, you can pay attention to "Erythromycin lactobionate", produced by a company from the United States. In the same country, a suspension for children "Ilozon" is made.
Powder for the suspension of "Erythromycin-Ratiofarm" is manufactured in Germany, in the same place are produced and granules for the preparation of syrup "Grunamycin".
Erythromycin-Teva, which is available in the form of tablets or powder for the preparation of suspensions, is manufactured in Israel. More affordable are imported products manufactured in India. In Russian pharmacies you can find "Erythromycin stearate" of Indian production - it is a tablet of 125 mg.
External means of
Popular use erythromycin ointment. Use this antibacterial drug as an external agent. The main active substance, as you might guess from the name, is erythromycin. Ointment( analogs are applied in the same way as the original drug) is easy to use. The product is spread on the affected area with a thin layer and neatly distributed. Intensively rub it is not worth it.
Before applying the ointment to the skin, clean the problem area and wipe it dry. After this, it is necessary to squeeze out a strip of the skin up to 3 cm on the skin. The ointment should be evenly distributed. The effect occurs if it is applied for 1-2 weeks to 4 times a day. Using such a scheme, you can get rid of teenage acne.
You can also use a solution. It is issued under the name "Eryfluid".To get rid of pimples, doctors recommend making lotions or compresses with this remedy. To do this, it is necessary to soak the cloth or cotton wool with a solution and apply it to the problem area for 5-15 minutes. Such compresses should be done for 2 weeks up to 3 times a day. But to increase the duration of the procedure is not necessary because of the risk of irritation.
Analogues of external tools
Some people do not trust cheap domestic drugs and are looking for a new generation of "Erythromycin" analogue. One of the known means is Zinerit. This lotion, made on the basis of erythromycin and zinc dihydrate acetate. The package contains 2 bottles. One contains the active ingredients, and the other contains the solvent. Of these, everyone alone can make a lotion. It is able to suppress the multiplication of organisms that cause acne.
"Klindovit" is often used as an analogue of an ointment, the main component of which is erythromycin. Indications for use and side effects in them, however, differ, because the drugs are made on the basis of different active substances. Gel "Klindovit" is used exclusively for combating acne. The course of treatment lasts more than 6 weeks.
For the treatment of boils, abscesses, acne, doctors can recommend the gel "Dalatsin".The main active substance in it, as in the drug "Clindovit", is clindamycin.
Use of antibacterial suspensions
If necessary, pediatricians prescribe antibacterial drugs in the form of suspensions to children, and in many of them the main active ingredient is erythromycin. Analogues( instructions for use allow the use of such tools, even for the treatment of newborns) doctors choose at their discretion.
A specialist can prescribe a suspension of "Ilozon" for infections of the upper respiratory tract or genitourinary system. Dosage is selected depending on the weight of the small patient. Children, depending on the complexity of the situation, may be prescribed from 30 to 50 mg of the drug per kilogram of body weight per day. This dosage is prescribed for patients aged 4 months to 18 years, although it is better for adolescents to buy a medicine in tablet form. And newborn babies, who have not yet turned 3 months old, are prescribed 20-40 mg of a suspension for each kilogram of their weight. In difficult cases, the dosage can be doubled.
Suspensions "Synerit", "Eomycin", "Grunamycin" and other products made on the basis of active substance erythromycin can be prescribed instead of "Ilozon".Analogues are taken in the same way and with the same indications as the Erythromycin tablets themselves.
Comparison of prices
When going to a pharmacy, many people want to know in advance how much to spend. It will depend only on what kind of medication the doctor has appointed. If you buy "Erythromycin" domestically produced, then you can significantly save. Packing of 10 tablets of 250 mg will cost 55 rubles. A bottle of lyophilizate in volume of 100 ml costs only 14 rubles.
Erythromycin ointment is also inexpensive. For a tube with a capacity of 15 g will have to pay about 26 rubles. But the remedy "Zinerit" will cost several times more: 30 ml of the drug costs 518 rubles. Tube gel "Klindovit" is about 289 rubles. The tool "Dalatsin" will cost less - for it you will have to pay 112 rubles.
Analogues of "Erythromycin" in tablets, made on the basis of other active substances, will also be more expensive. For example, tablets "Sumamed"( 500 mg No. 3) will cost 447 rubles. But the drug "Macropen" will cost 246 rubles. This amount will have to pay for a package of 16 tablets of 400 mg.
Efficacy of drugs: feedback from people
It is difficult to compare the effectiveness of taking different antibacterial agents. After all, a certain active substance is active against a number of sensitive microorganisms. But if you need to treat infections caused by microorganisms, which can affect erythromycin, then this drug is considered one of the best.
Despite the affordable price, its efficiency remains at an altitude, which is confirmed by many reviews. Of course, at the request of patients it can be replaced by other, more expensive, means. But this, according to experts, will not accelerate the process of recovery.
All antibiotics doctors recommend to drink more 2-3 days after the condition is improved. Not an exception and "Erythromycin".Analogues are drunk in the same way as the original drug.
Depending on the indications and complexity of the condition, the treatment can last from 7 to 14 days. For adults, the daily dose is 1-2 g. But in severe cases, you can appoint and for 4 g.
You can not increase the dosage of the drug for increased efficiency without the urgent need. After all, this can lead to negative consequences. Among them, doctors call hearing loss and the development of acute liver failure.