"Fosfomycin": analogues, instructions and reviews

Despite the fact that antibacterial agents have a large number of side effects, one can not always refuse to use them. The main thing is that the drug is properly selected and provides the necessary result.

The drug "Fosfomycin" is highly effective in the treatment of infections. Analogues of the drug have a similar effect."Fosfomycin" is available in the form of water-soluble granules and powder, intended for the preparation of solutions, has a wide spectrum of antimicrobial activity.

The mechanism of action of the drug

Antibiotic is effective in diseases, the development of which occurs due to the impact on the body of harmful bacteria( gram-positive and gram-negative).Antimicrobial effect is achieved due to the active substance of phosphomycin trometamol. Antibacterial action is carried out by disrupting the formation of the bacterial cell wall.

Pharmacokinetics

When a high concentration of the active ingredient is present in the blood plasma, the maximum activity of the drug "Fosfomycin" is observed. The instruction shows that this occurs 2-2.5 hours after the penetration of the drug into the body."Fosfomycin" is suitable for parenteral and oral administration. The drug, taken by mouth, is quickly absorbed into the digestive tract, decomposes into phosphomycin and trometamol. Absorption is in the range from 34% to 65%( eating helps reduce the index, so it is better to drink medicine on an empty stomach).Half-life takes 4 hours. Trometamol phosphomycin is completely excreted from the body with feces and urine, mostly kidney( about 90%).

Indications for use

Usually "Fosfomycin", the analogs of the drug are taken orally for infectious diseases of the urinary system. The drug successfully treats cystitis and urethritis of bacterial etiology, extensive bacteriuria, which sometimes develops in pregnant women and may not manifest itself in any way. In the postoperative period, this antibacterial agent helps prevent the occurrence of infectious pathologies.

Injection administration is indicated in the treatment of a large number of diseases caused by the defeat of the body by bacteria:

• purulent pleurisy;
• acute cystitis;
• pyelonephritis;
• adnexitis;
• septicemia;
• pneumonia;
• bronchiectatic disease;
• infection of the pelvic organs.

In case of severe illness, combined treatment is possible, when other antibacterial drugs are used in addition to "Fosfomycin".Basically, "Fosfomycin"( analogs) is used in conjunction with beta-lactam antibiotics.

Contraindications and restrictions

The drug is not prescribed for hypersensitivity to the active ingredient and auxiliary components. The drug is contraindicated in patients who have a renal failure( creatinine clearance does not exceed 10 ml / min.).

For violations of the functions of the liver and kidneys, "Fosfomycin" is used with caution, during pregnancy and lactation - only under the supervision of a specialist.

Limited use of the drug in the treatment of patients aged 5 years and over 75 years( children under 5 years of age "Fosfomycin" is rarely prescribed).

Application of "Fosfomycin"

Inside use granules previously dissolved in water, for injections, take an injection solution prepared from the powder of the drug "Fosfomycin".Analogues and this remedy are used in doses recommended by the attending physician. Dosage depends on the disease and its severity.

The instructions indicate the maximum dosage of the drug when ingested: for children - 2 g per day, for adults - 3 g per day. Intravenous child can be administered not more than 100-200 mg / kg of weight, adult - no more than 2-4 g. Granules are taken once, on an empty stomach or 2 hours after eating. In this case, the next meal is possible not earlier than 2 hours later. It is advisable to take the medicine before going to bed after emptying the bladder.

Side effects of

A drug with phosphomycin trometamol, analogues of this drug, like any other antibiotics, can lead to the development of unwanted reactions of the body. The following abnormalities in the digestive tract are possible:

• stool change;
• flatulence;
• nausea followed by vomiting.

From the nervous system side, there is sometimes an increased nervousness, dizziness, headache, a person always wants to sleep.

Injections can cause pain at the injection site, a feeling of thirst. After the administration of the drug in this way, some patients experience thrombocytopenia, leukopenia, of allergic manifestations - anaphylactic shock, skin itching, rash, urticaria. Side effects also include the appearance of peripheral edema and seizures. Other side effects are possible.

In case of an overdose, undesirable reactions are more pronounced. It is important to drink plenty of fluids, in addition, you need to carry out symptomatic treatment.

Following the detection of side effects of the drug "Fosfomycin", the instruction prohibits its further use. The doctor should be replaced by a medicinal product.

Special instructions

The interaction of the drug with other substances should be considered. It is not recommended to take with the agent "Metoclopramide", because the result of their joint use is a decrease in the effectiveness of "Fosfomycin."

Do not take medicine for patients prone to allergic manifestations. Since the drug penetrates into breast milk, treatment during lactation should be discontinued or performed with caution.

"Fosfomycin", analogues, synonyms of the drug are taken by courses. During the period of treatment, you should not miss the medication, you should use it at the same intervals. If there was a pass, the proper dose of the drug should be taken as soon as possible( only if you do not need to take the next dose in the near future).

Analogues, reviews

Instead of the preparation "Fosfomycin", analog drugs and drugs-synonyms can be used. But they must be chosen by the attending physician. It should be noted that Urofosfabol and Monural are often used instead of the means in question. They quite successfully can replace "Fosfomycin".Analogues in Ukraine are represented by these drugs. These drugs are good at dealing with the tasks and can be used to treat the same diseases as "Fosfomycin."Like other antibacterial agents, they have some side effects."Urophosfabol", "Monural" is taken with extreme caution, the same goes for the medicine "Fosfomycin".The analogue in Russia, which is the most popular - "Monural", but also "Urophosfabol" is also in pharmacies.

"Monural" is often prescribed for the treatment of acute infectious diseases of the urinary tract, which proceed without complications and are caused by microorganisms that are sensitive to this drug. The drug is used in operations and diagnostic procedures."Urophosfabol" treats infectious and inflammatory diseases, but only those that are sensitive to its active substance. There are few options that can replace "Fosfomycin".Analogues, Ukraine and Russia use the same.

Reviews show that "Fosfomycin" can not always be found in pharmacies, and its cost is high, not everyone can buy. But "Monural" is always available. It is cheaper, but it works no worse. Those who took "Fosfomycin" noticed that the required effect was rather fast. However, not all people notice positive changes in their lives. Sometimes, in order to cure the disease, you have to prescribe another drug. In some cases, adverse reactions occur, since the body of each person has its own characteristics and reacts to the substances present in the composition of the preparations in different ways.